- Plasma membrane-localized transporter for aluminum in rice
[作者:Xia, JX; Yamaji, N; Kasai, T; Ma, JAF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18381-18385 , 文章类型: Article,,卷期:2010年107-43]
- Aluminum (Al) is the most abundant metal in the Earth's crust, but its trivalent ionic form is highly toxic to all organisms at low concentrations. How Al enters cells has not been elucidated in any organisms. Herein, we...
- Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis
[作者:Cornelissen, I; Palmer, D; David, T; Wilsbacher, L; Concengco, C; Conley, P; Pandey, A; Coughlin, SR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18605-18610 , 文章类型: Article,,卷期:2010年107-43]
- Toward understanding their redundancies and interactions in hemostasis and thrombosis, we examined the roles of thrombin receptors (protease-activated receptors, PARs) and the ADP receptor P2RY12 (purinergic receptor P2Y...
- Acceleration of wound healing by growth hormone-releasing hormone and its agonists
[作者:Dioufa, N; Schally, AV; Chatzistamou, I; Moustou, E; Block, NL; Owens, GK; Papavassiliou, AG; Kiaris, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18611-18615 , 文章类型: Article,,卷期:2010年107-43]
- Despite the well-documented action of growth hormone-releasing hormone (GHRH) on the stimulation of production and release of growth hormone (GH), the effects of GHRH in peripheral tissues are incompletely explored. In t...
- Middle Pleistocene lower back and pelvis from an aged human individual from the Sima de los Huesos site, Spain
[作者:Bonmati, A; Gomez-Olivencia, A; Arsuaga, JL; Carretero, JM; Gracia, A; Martinez, I; Lorenzo, C; de Castro, JMB; Carbonell, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18386-18391 , 文章类型: Article,,卷期:2010年107-43]
- We report a nearly complete lumbar spine from the Middle Pleistocene site of the Sima de los Huesos (SH) that is assigned to the previously published SH male Pelvis 1 [Arsuaga JL, et al. (1999). Nature 399: 255-258]. The...
- Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
[作者:Stott, SL; Hsu, CH; Tsukrov, DI; Yu, M; Miyamoto, DT; Waltman, BA; Rothenberg, SM; Shah, AM; Smas, ME; Korir, GK; Floyd, FP; Gilman, AJ; Lord, JB; Winokur, D; Springer, S; Irimia, D; Nagrath, S; Sequist, LV; Lee, RJ; Isselbacher, KJ; Maheswaran, S; Haber, DA; Toner, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18392-18397 , 文章类型: Article,,卷期:2010年107-43]
- Rare circulating tumor cells (CTCs) present in the bloodstream of patients with cancer provide a potentially accessible source for detection, characterization, and monitoring of nonhematological cancers. We previously de...
- Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression
[作者:DeLisser, H; Liu, Y; Desprez, PY; Thor, A; Briasouli, P; Handumrongkul, C; Wilfong, J; Yount, G; Nosrati, M; Fong, S; Shtivelman, E; Fehrenbach, M; Cao, GY; Moore, DH; Nyack, S; Liggitt, D; Kashani-Sabet, M; Debs, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18616-18621 , 文章类型: Article,,卷期:2010年107-43]
- Most patients who die from cancer succumb to treatment-refractory advanced metastatic progression. Although the early stages of tumor metastasis result in the formation of clinically silent micrometastatic foci, its late...
- p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
[作者:Siu, MKY; Chan, HY; Kong, DSH; Wong, ESY; Wong, OGW; Ngan, HYS; Tam, KF; Zhang, HQ; Li, ZL; Chan, QKY; Tsao, SW; Stromblad, S; Cheung, ANY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18622-18627 , 文章类型: Article,,卷期:2010年107-43]
- Ovarian cancer is a lethal gynecological malignancy, and to improve survival, it is important to identify novel prognostic and therapeutic targets. In this study, we present a role for p21-activated kinase 4 (Pak4) in ov...
- Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain
[作者:Liu, K; Chen, C; Guo, YH; Lam, R; Bian, CB; Xu, C; Zhao, DY; Jin, J; MacKenzie, F; Pawson, T; Min, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18398-18403 , 文章类型: Article,,卷期:2010年107-43]
- Arginine methylation modulates diverse cellular processes and represents a molecular signature of germ-line-specific Piwi family proteins. A subset of Tudor domains recognize arginine methylation modifications, but the b...
- Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)
[作者:Matsushima, Y; Goto, Y; Kaguni, LS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18410-18415 , 文章类型: Article,,卷期:2010年107-43]
- Lon is the major protease in the mitochondrial matrix in eukaryotes, and is well conserved among species. Although a role for Lon in mitochondrial biogenesis has been proposed, the mechanistic basis is unclear. Here, we ...
- Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype
[作者:De Luca, A; Sanna, F; Sallese, M; Ruggiero, C; Grossi, M; Sacchetta, P; Rossi, C; De Laurenzi, V; Di Ilio, C; Favaloro, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18628-18633 , 文章类型: Article,,卷期:2010年107-43]
- Breast cancer is one of the most frequent of human malignacies, and it is therefore fundamental to identify the underlying molecular mechanisms leading to cancer transformation. Among other causative agents in the develo...
- Development of the malaria parasite in the skin of the mammalian host
[作者:Gueirard, P; Tavares, J; Thiberge, S; Bernex, F; Ishino, T; Milon, G; Franke-Fayard, B; Janse, CJ; Menard, R; Amino, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18640-18645 , 文章类型: Article,,卷期:2010年107-43]
- The first step of Plasmodium development in vertebrates is the transformation of the sporozoite, the parasite stage injected by the mosquito in the skin, into merozoites, the stage that invades erythrocytes and initiates...
- Appropriation of the MinD protein-interaction motif by the dimeric interface of the bacterial cell division regulator MinE
[作者:Ghasriani, H; Ducat, T; Hart, CT; Hafizi, F; Chang, N; Al-Baldawi, A; Ayed, SH; Lundstrom, P; Dillon, JAR; Goto, NK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18416-18421 , 文章类型: Article,,卷期:2010年107-43]
- MinE is required for the dynamic oscillation of Min proteins that restricts formation of the cytokinetic septum to the midpoint of the cell in gram negative bacteria. Critical for this oscillation is MinD-binding by MinE...
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