- Highly conserved tyrosine stabilizes the active state of rhodopsin
[作者:Goncalves, JA; South, K; Ahuja, S; Zaitseva, E; Opefi, CA; Eilers, M; Vogel, R; Reeves, PJ; Smith, SO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19861-19866 , 文章类型: Article,,卷期:2010年107-46]
- Light-induced isomerization of the 11-cis-retinal chromophore in the visual pigment rhodopsin triggers displacement of the second extracellular loop (EL2) and motion of transmembrane helices H5, H6, and H7 leading to the...
- Human ISWI chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites
[作者:Erdel, F; Schubert, T; Marth, C; Langst, G; Rippe, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19867-19872 , 文章类型: Article,,卷期:2010年107-46]
- Chromatin remodeling complexes can translocate nucleosomes along the DNA in an ATP-dependent manner. Here, we studied autofluorescent protein constructs of the human ISWI family members Snf2H, Snf2L, the catalytically in...
- Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders
[作者:Neasta, J; Hamida, SB; Yowell, Q; Carnicella, S; Ron, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20093-20098 , 文章类型: Article,,卷期:2010年107-46]
- Alcohol addiction is a chronically relapsing disorder that includes certain maladaptive learning and memory. The serine and threonine kinase complex, mammalian target of rapamycin complex 1 (mTORC1), has been implicated ...
- Climate mitigation and the future of tropical landscapes
[作者:Thomson, AM; Calvin, KV; Chini, LP; Hurtt, G; Edmonds, JA; Bond-Lamberty, B; Frolking, S; Wise, MA; Janetos, AC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19633-19638 , 文章类型: Article,,卷期:2010年107-46]
- Land-use change to meet 21st-century demands for food, fuel, and fiber will depend on many interactive factors, including global policies limiting anthropogenic climate change and realized improvements in agricultural pr...
- A network connecting Runx2, SATB2, and the miR-23a similar to 27a similar to 24-2 cluster regulates the osteoblast differentiation program
[作者:Hassan, MQ; Gordon, JAR; Beloti, MM; Croce, CM; van Wijnen, AJ; Stein, JL; Stein, GS; Lian, JB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19879-19884 , 文章类型: Article,,卷期:2010年107-46]
- Induced osteogenesis includes a program of microRNAs (miRs) to repress the translation of genes that act as inhibitors of bone formation. How expression of bone-related miRs is regulated remains a compelling question. He...
- Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation
[作者:Wang, RN; Jung, SY; Wu, CF; Qin, J; Kobayashi, R; Gallick, GE; Kuang, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19885-19890 , 文章类型: Article,,卷期:2010年107-46]
- The induction of M phase in eukaryotic cell cycles requires robust activation of Cdc2/cyclin B by Cdc25, which itself is robustly activated by serine/threonine phosphorylations. Although multiple protein kinases that dir...
- Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors
[作者:Akimoto, C; Ueda, T; Inoue, K; Yamaoka, I; Sakari, M; Obara, W; Fujioka, T; Nagahara, A; Nonomura, N; Tsutsumi, S; Aburatani, H; Miki, T; Matsumoto, T; Kitagawa, H; Kato, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19891-19896 , 文章类型: Article,,卷期:2010年107-46]
- Testis-specific protein on Y chromosome (TSPY) is an ampliconic gene on the Y chromosome, and genetic interaction with gonadoblastoma has been clinically established. However, the function of the TSPY protein remains to ...
- Topographic maps of multisensory attention
[作者:Anderson, JS; Ferguson, MA; Lopez-Larson, M; Yurgelun-Todd, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20110-20114 , 文章类型: Article,,卷期:2010年107-46]
- The intraparietal sulcus (IPS) region is uniquely situated at the intersection of visual, somatosensory, and auditory association cortices, ideally located for processing of multisensory attention. We examined the intern...
- Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi
[作者:Moreno, Y; Nabhan, JF; Solomon, J; Mackenzie, CD; Geary, TG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20120-20125 , 文章类型: Article,,卷期:2010年107-46]
- Ivermectin (IVM) is a broad-spectrum anthelmintic used in filariasis control programs. By binding to nematode glutamate-gated chloride channels (GluCls), IVM disrupts neurotransmission processes regulated by GluCl activi...
- Trading carbon for food: Global comparison of carbon stocks vs. crop yields on agricultural land
[作者:West, PC; Gibbs, HK; Monfreda, C; Wagner, J; Barford, CC; Carpenter, SR; Foley, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19645-19648 , 文章类型: Article,,卷期:2010年107-46]
- Expanding croplands to meet the needs of a growing population, changing diets, and biofuel production comes at the cost of reduced carbon stocks in natural vegetation and soils. Here, we present a spatially explicit glob...
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