- PB2 and Hemagglutinin Mutations Are Major Determinants of Host Range and Virulence in Mouse-Adapted Influenza A Virus
[作者:Ping, JH; Dankar, SK; Forbes, NE; Keleta, L; Zhou, Y; Tyler, S; Brown, EG,期刊:Journal of virology, 页码:10606-10618 , 文章类型: Article,,卷期:2010年84-20]
- Serial mouse lung passage of a human influenza A virus, A/Hong Kong/1/68 (H3N2) (HK-wt), produced a mouse-adapted variant, MA, with nine mutations that was >10(3.8)-fold more virulent. In this study, we demonstrate that ...
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