- GIPC1 Interacts with MyoGEF and Promotes MDA-MB-231 Breast Cancer Cell Invasion
[作者:Wu, D; Haruta, A; Wei, QZ,期刊:Journal of Biological Chemistry, 页码:28643-28650 , 文章类型: Article,,卷期:2010年285-37]
- GIPC1/synectin, a single PDZ domain-containing protein, binds to numerous proteins and is involved in multiple biological processes, including cell migration. We reported previously that MyoGEF, a guanine nucleotide exch...
- Binding of the Receptor Tyrosine Kinase TrkB to the Neural Cell Adhesion Molecule (NCAM) Regulates Phosphorylation of NCAM and NCAM-dependent Neurite Outgrowth
[作者:Cassens, C; Kleene, R; Xiao, MF; Friedrich, C; Dityateva, G; Schafer-Nielsen, C; Schachner, M,期刊:Journal of Biological Chemistry, 页码:28959-28967 , 文章类型: Article,,卷期:2010年285-37]
- Recognition molecules and neurotrophins play important roles during development and maintenance of nervous system functions. In this study, we provide evidence that the neural cell adhesion molecule (NCAM) and the neurot...
- Functional Consequences of the Interactions among the Neural Cell Adhesion Molecule NCAM, the Receptor Tyrosine Kinase TrkB, and the Inwardly Rectifying K+ Channel KIR3.3
[作者:Kleene, R; Cassens, C; Bahring, R; Theis, T; Xiao, MF; Dityatev, A; Schafer-Nielsen, C; Doring, F; Wischmeyer, E; Schachner, M,期刊:Journal of Biological Chemistry, 页码:28968-28979 , 文章类型: Article,,卷期:2010年285-37]
- Cell adhesion molecules and neurotrophin receptors are crucial for the development and the function of the nervous system. Among downstream effectors of neurotrophin receptors and recognition molecules are ion channels. ...
- p47(phox) Molecular Activation for Assembly of the Neutrophil NADPH Oxidase Complex
[作者:Marcoux, J; Man, P; Petit-Haertlein, I; Vives, C; Forest, E; Fieschi, F,期刊:Journal of Biological Chemistry, 页码:28980-28990 , 文章类型: Article,,卷期:2010年285-37]
- The p47(phox) cytosolic factor from neutrophilic NADPH oxidase has always been resistant to crystallogenesis trials due to its modular organization leading to relative flexibility. Hydrogen/deuterium exchange coupled to ...
- The Plasma Membrane of Bloodstream-form African Trypanosomes Confers Susceptibility and Specificity to Killing by Hydrophobic Peptides
[作者:Harrington, JM; Widener, J; Stephens, N; Johnson, T; Francia, M; Capewell, P; Macleod, A; Hajduk, SL,期刊:Journal of Biological Chemistry, 页码:28659-28666 , 文章类型: Article,,卷期:2010年285-37]
- Trypanosoma brucei is the causative agent of both a veterinary wasting disease and human African trypanosomiasis, or sleeping sickness. The cell membrane of the developmental stage found within the mammalian host, the bl...
- Polo Kinase Interacts with RacGAP50C and Is Required to Localize the Cytokinesis Initiation Complex
[作者:Ebrahimi, S; Fraval, H; Murray, M; Saint, R; Gregory, SL,期刊:Journal of Biological Chemistry, 页码:28667-28673 , 文章类型: Article,,卷期:2010年285-37]
- The assembly and constriction of an actomyosin contractile ring in cytokinesis is dependent on the activation of Rho at the equatorial cortex by a complex, here termed the cytokinesis initiation complex, between a microt...
- Neuroligin Trafficking Deficiencies Arising from Mutations in the alpha/beta-Hydrolase Fold Protein Family
[作者:De Jaco, A; Lin, MZ; Dubi, N; Comoletti, D; Miller, MT; Camp, S; Ellisman, M; Butko, MT; Tsien, RY; Taylor, P,期刊:Journal of Biological Chemistry, 页码:28674-28682 , 文章类型: Article,,卷期:2010年285-37]
- Despite great functional diversity, characterization of the alpha/beta-hydrolase fold proteins that encompass a superfamily of hydrolases, heterophilic adhesion proteins, and chaperone domains reveals a common structural...
- Cu,Zn Superoxide Dismutase Maturation and Activity Are Regulated by COMMD1
[作者:Vonk, WIM; Wijmenga, C; Berger, R; van de Sluis, B; Klomp, LWJ,期刊:Journal of Biological Chemistry, 页码:28991-29000 , 文章类型: Article,,卷期:2010年285-37]
- The maturation and activation of the anti-oxidant Cu, Zn superoxide dismutase (SOD1) are highly regulated processes that require several post-translational modifications. The maturation of SOD1 is initiated by incorporat...
- Molecular Basis for Barbed End Uncapping by CARMIL Homology Domain 3 of Mouse CARMIL-1
[作者:Zwolak, A; Uruno, T; Piszczek, G; Hammer, JA; Tjandra, N,期刊:Journal of Biological Chemistry, 页码:29014-29026 , 文章类型: Article,,卷期:2010年285-37]
- Capping protein (CP) is a ubiquitously expressed, 62-kDa heterodimer that binds the barbed end of the actin filament with similar to 0.1 nM affinity to prevent further monomer addition. CARMIL is a multidomain protein, p...
- Post-transcriptional Mechanisms Contribute to the Suppression of the ErbB3 Negative Regulator Protein Nrdp1 in Mammary Tumors
[作者:Ingalla, EQ; Miller, JK; Wald, JH; Workman, HC; Kaur, RP; Yen, L; Fry, WHD; Borowsky, AD; Young, LJT; Sweeney, C; Carraway, KL,期刊:Journal of Biological Chemistry, 页码:28691-28697 , 文章类型: Article,,卷期:2010年285-37]
- The ErbB2 and ErbB3 receptor tyrosine kinases act synergistically to promote cellular properties associated with tumor development. Previous studies indicate that endogenous ErbB3 protein is markedly elevated in mouse ma...
- Ribosome Modulation Factor, an Important Protein for Cell Viability Encoded by the Polyamine Modulon
[作者:Terui, Y; Tabei, Y; Akiyama, M; Higashi, K; Tomitori, H; Yamamoto, K; Ishihama, A; Igarashi, K; Kashiwagi, K,期刊:Journal of Biological Chemistry, 页码:28698-28707 , 文章类型: Article,,卷期:2010年285-37]
- We searched for proteins whose synthesis is enhanced by polyamines at the stationary phase of cell growth using an Escherichia coli polyamine-requiring mutant in which cell viability is greatly decreased by polyamine def...
- Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain
[作者:Volpicelli-Daley, LA; Lucast, L; Gong, LW; Liu, LJ; Sasaki, J; Sasaki, T; Abrams, CS; Kanaho, Y; De Camilli, P,期刊:Journal of Biological Chemistry, 页码:28708-28714 , 文章类型: Article,,卷期:2010年285-37]
- The predominant pathway for phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P-2) synthesis is thought to be phosphorylation of phosphatidylinositol 4-phosphate at the 5 position of the inositol ring by type I phosphatidy...
- Autophagy Facilitates IFN-gamma-induced Jak2-STAT1 Activation and Cellular Inflammation
[作者:Chang, YP; Tsai, CC; Huang, WC; Wang, CY; Chen, CL; Lin, YS; Kai, JI; Hsieh, CY; Cheng, YL; Choi, PC; Chen, SH; Chang, SP; Liu, HS; Lin, CF,期刊:Journal of Biological Chemistry, 页码:28715-28722 , 文章类型: Article,,卷期:2010年285-37]
- Autophagy is regulated for IFN-gamma-mediated antimicrobial efficacy; however, its molecular effects for IFN-gamma signaling are largely unknown. Here, we show that autophagy facilitates IFN-gamma-activated Jak2-STAT1. I...
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