- The ATP Synthase a-subunit of Extreme Alkaliphiles Is a Distinct Variant MUTATIONS IN THE CRITICAL ALKALIPHILE-SPECIFIC RESIDUE LYS-180 AND OTHER RESIDUES THAT SUPPORT ALKALIPHILE OXIDATIVE PHOSPHORYLATION
[作者:Fujisawa, M; Fackelmayer, OJ; Liu, J; Krulwich, TA; Hicks, DB,期刊:Journal of Biological Chemistry, 页码:32105-32115 , 文章类型: Article,,卷期:2010年285-42]
- A lysine residue in the putative proton uptake pathway of the ATP synthase a-subunit is found only in alkaliphilic Bacillus species and is proposed to play roles in proton capture, retention and passage to the synthase r...
- Differential Effects of Ceramide and Sphingosine 1-Phosphate on ERM Phosphorylation PROBING SPHINGOLIPID SIGNALING AT THE OUTER PLASMA MEMBRANE
[作者:Canals, D; Jenkins, RW; Roddy, P; Hernandez-Corbacho, MJ; Obeid, LM; Hannun, YA,期刊:Journal of Biological Chemistry, 页码:32476-32485 , 文章类型: Article,,卷期:2010年285-42]
- ERM proteins are regulated by phosphorylation of the most C-terminal threonine residue, switching them from an activated to an inactivated form. However, little is known about the control of this regulation. Previous wor...
- Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins
[作者:Varkey, J; Isas, JM; Mizuno, N; Jensen, MB; Bhatia, VK; Jao, CC; Petrlova, J; Voss, JC; Stamou, DG; Steven, AC; Langen, R,期刊:Journal of Biological Chemistry, 页码:32486-32493 , 文章类型: Article,,卷期:2010年285-42]
- Synucleins and apolipoproteins have been implicated in a number of membrane and lipid trafficking events. Lipid interaction for both types of proteins is mediated by 11 amino acid repeats that form amphipathic helices. T...
- Carbon Monoxide Promotes VEGF Expression by Increasing HIF-1 alpha Protein Level via Two Distinct Mechanisms, Translational Activation and Stabilization of HIF-1 alpha Protein
[作者:Choi, YK; Kim, CK; Lee, H; Jeoung, D; Ha, KS; Kwon, YG; Kim, KW; Kim, YM,期刊:Journal of Biological Chemistry, 页码:32116-32125 , 文章类型: Article,,卷期:2010年285-42]
- Carbon monoxide (CO) plays a significant role in vascular functions. We here examined the molecular mechanism by which CO regulates HIF-1 (hypoxia-inducible transcription factor-1)-dependent expression of vascular endoth...
- A Lethal de Novo Mutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division
[作者:Chang, CR; Manlandro, CM; Arnoult, D; Stadler, J; Posey, AE; Hill, RB; Blackstone, C,期刊:Journal of Biological Chemistry, 页码:32494-32503 , 文章类型: Article,,卷期:2010年285-42]
- Mitochondria dynamically fuse and divide within cells, and the proper balance of fusion and fission is necessary for normal mitochondrial function, morphology, and distribution. Drp1 is a dynamin-related GTPase required ...
- Structure and Metal Loading of a Soluble Periplasm Cuproprotein
[作者:Waldron, KJ; Firbank, SJ; Dainty, SJ; Perez-Rama, M; Tottey, S; Robinson, NJ,期刊:Journal of Biological Chemistry, 页码:32504-32511 , 文章类型: Article,,卷期:2010年285-42]
- A copper-trafficking pathway was found to enable Cu2+ occupancy of a soluble periplasm protein, CucA, even when competing Zn2+ is abundant in the periplasm. Here, we solved the structure of CucA (a new cupin) and found t...
- ZRT/IRT-like Protein 14 (ZIP14) Promotes the Cellular Assimilation of Iron from Transferrin
[作者:Zhao, NN; Gao, JW; Enns, CA; Knutson, MD,期刊:Journal of Biological Chemistry, 页码:32141-32150 , 文章类型: Article,,卷期:2010年285-42]
- ZIP14 is a transmembrane metal ion transporter that is abundantly expressed in the liver, heart, and pancreas. Previous studies of HEK 293 cells and the hepatocyte cell lines AML12 and HepG2 established that ZIP14 mediat...
- A Small GTPase Activator Protein Interacts with Cytoplasmic Phytochromes in Regulating Root Development
[作者:Shin, DH; Cho, MH; Kim, TL; Yoo, J; Kim, JI; Han, YJ; Song, PS; Jeon, JS; Bhoo, SH; Hahn, TR,期刊:Journal of Biological Chemistry, 页码:32151-32159 , 文章类型: Article,,卷期:2010年285-42]
- Phytochromes enable plants to sense light information and regulate developmental responses. Phytochromes interact with partner proteins to transmit light signals to downstream components for plant development. PIRF1 (phy...
- Pro-inflammatory Genes as Biomarkers and Therapeutic Targets in Oral Squamous Cell Carcinoma
[作者:Rao, SK; Pavicevic, Z; Du, ZY; Kim, JG; Fan, MY; Jiao, Y; Rosebush, M; Samant, S; Gu, WK; Pfeffer, LM; Nosrat, CA,期刊:Journal of Biological Chemistry, 页码:32512-32521 , 文章类型: Article,,卷期:2010年285-42]
- Oral squamous cell carcinoma (OSCC) is a major health problem worldwide, and patients have a particularly poor 5-year survival rate. Thus, identification of the molecular targets in OSCC and subsequent innovative therapi...
- Metabolic Depression and Increased Reactive Oxygen Species Production by Isolated Mitochondria at Moderately Lower Temperatures
[作者:Ali, SS; Marcondes, MCG; Bajova, H; Dugan, LL; Conti, B,期刊:Journal of Biological Chemistry, 页码:32522-32528 , 文章类型: Article,,卷期:2010年285-42]
- Temperature (T) reduction increases lifespan, but the mechanisms are not understood. Because reactive oxygen species (ROS) contribute to aging, we hypothesized that lowering T might decrease mitochondrial ROS production....
- A New Kv1.2 Channelopathy Underlying Cerebellar Ataxia
[作者:Xie, G; Harrison, J; Clapcote, SJ; Huang, Y; Zhang, JY; Wang, LY; Roder, JC,期刊:Journal of Biological Chemistry, 页码:32160-32173 , 文章类型: Article,,卷期:2010年285-42]
- A forward genetic screen of mice treated with the mutagen ENU identified a mutant mouse with chronic motor incoordination. This mutant, named Pingu (Pgu), carries a missense mutation, an I402T substitution in the S6 segm...
- Isolation of SPINK6 in Human Skin SELECTIVE INHIBITOR OF KALLIKREIN-RELATED PEPTIDASES
[作者:Meyer-Hoffert, U; Wu, ZH; Kantyka, T; Fischer, J; Latendorf, T; Hansmann, B; Bartels, J; He, YH; Glaser, R; Schroder, JM,期刊:Journal of Biological Chemistry, 页码:32174-32181 , 文章类型: Article,,卷期:2010年285-42]
- Kallikrein-related peptidases (KLKs) play a central role in skin desquamation. They are tightly controlled by specific inhibitors, including the lymphoepithelial Kazal-type inhibitor (LEKTI) encoded by SPINK5 and LEKTI-2...
- Tissue-nonspecific Alkaline Phosphatase Promotes the Neurotoxicity Effect of Extracellular Tau
[作者:Diaz-Hernandez, M; Gomez-Ramos, A; Rubio, A; Gomez-Villafuertes, R; Naranjo, JR; Miras-Portugal, MT; Avila, J,期刊:Journal of Biological Chemistry, 页码:32539-32548 , 文章类型: Article,,卷期:2010年285-42]
- There is solid evidence indicating that hyperphosphorylated tau protein, the main component of intracellular neurofibrillary tangles present in the brain of Alzheimer disease patients, plays a key role in progression of ...
- AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB center dot CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner
[作者:Lee, JM; Seo, WY; Song, KH; Chanda, D; Kim, YD; Kim, DK; Lee, MW; Ryu, D; Kim, YH; Noh, JR; Lee, CH; Chiang, JYL; Koo, SH; Choi, HS,期刊:Journal of Biological Chemistry, 页码:32182-32191 , 文章类型: Article,,卷期:2010年285-42]
- Orphan nuclear receptor small heterodimer partner (SHP) plays a key role in transcriptional repression of gluconeogenic enzyme gene expression. Here, we show that SHP inhibited protein kinase A-mediated transcriptional a...
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