- Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of gamma-Secretase Activity toward Amyloid Precursor Protein and Other Substrates
[作者:Gong, P; Vetrivel, KS; Nguyen, PD; Meckler, X; Cheng, HP; Kounnas, MZ; Wagner, SL; Parent, AT; Thinakaran, G,期刊:Journal of Biological Chemistry, 页码:38042-38052 , 文章类型: Article,,卷期:2010年285-49]
- The gamma-secretase protein complex executes the intramembrane proteolysis of amyloid precursor protein (APP), which releases Alzheimer disease beta-amyloid peptide. In addition to APP, gamma-secretase also cleaves sever...
- Noncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase II
[作者:Diebold, ML; Loeliger, E; Koch, M; Winston, F; Cavarelli, J; Romier, C,期刊:Journal of Biological Chemistry, 页码:38389-38398 , 文章类型: Article,,卷期:2010年285-49]
- Src homology 2 (SH2) domains are mostly found in multicellular organisms where they recognize phosphotyrosine-containing signaling proteins. Spt6, a conserved transcription factor and putative histone chaperone, contains...
- Molecular Phylogeny and Functional Genomics of beta-Galactoside alpha 2,6-Sialyltransferases That Explain Ubiquitous Expression of st6gal1 Gene in Amniotes
[作者:Petit, D; Mir, AM; Petit, JM; Thisse, C; Delannoy, P; Oriol, R; Thisse, B; Harduin-Lepers, A,期刊:Journal of Biological Chemistry, 页码:38399-38414 , 文章类型: Article,,卷期:2010年285-49]
- Sialyltransferases are key enzymes in the biosynthesis of sialoglycoconjugates that catalyze the transfer of sialic residue from its activated form to an oligosaccharidic acceptor. beta-Galactoside alpha 2,6-sialyltransf...
- Morphine Modulation of Thrombospondin Levels in Astrocytes and Its Implications for Neurite Outgrowth and Synapse Formation
[作者:Ikeda, H; Miyatake, M; Koshikawa, N; Ochiai, K; Yamada, K; Kiss, A; Donlin, MJ; Panneton, WM; Churchill, JD; Green, M; Siddiqui, AM; Leinweber, AL; Crews, NR; Ezerskiy, LA; Rendell, VR; Belcheva, MM; Coscia, CJ,期刊:Journal of Biological Chemistry, 页码:38415-38427 , 文章类型: Article,,卷期:2010年285-49]
- Opioid receptor signaling via EGF receptor (EGFR) transactivation and ERK/MAPK phosphorylation initiates diverse cellular responses that are cell type-dependent. In astrocytes, multiple mu opioid receptor-mediated mechan...
- TDP-43 is a developmentally regulated protein essential for early embryonic development (vol 285, pg 6826, 2010)
[作者:Sephton, CF; Good, SK; Atkin, S; Dewey, CM; Mayer, P; Herz, J; Yu, G,期刊:Journal of Biological Chemistry, 页码:38740-38740 , 文章类型: Correction,,卷期:2010年285-49]
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- Serpins flex their muscle. I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS (vol 285, pg 24299, 2010)
[作者:Silverman, GA; Whisstock, JC; Bottomley, SP; Huntington, JA; Kaiserman, D; Luke, CJ; Pak, SC; Reichhart, JM; Bird, PI,期刊:Journal of Biological Chemistry, 页码:38740-38740 , 文章类型: Correction,,卷期:2010年285-49]
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- Location, location, location: compartmentalization of early events in leukotriene biosynthesis (vol 285, pg 25109, 2010)
[作者:Newcomer, ME; Gilbert, NC,期刊:Journal of Biological Chemistry, 页码:38740-38740 , 文章类型: Correction,,卷期:2010年285-49]
- HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking (vol 285, pg 30884, 2010)
[作者:Yi, L; Rosales, T; Rose, JJ; Chowdhury, B; Knutson, JR; Venkatesan, S,期刊:Journal of Biological Chemistry, 页码:38740-38740 , 文章类型: Correction,,卷期:2010年285-49]
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- Timing of Gene Transcription in the Galactose Utilization System of Escherichia coli
[作者:Horvath, P; Hunziker, A; Erdossy, J; Krishna, S; Semsey, S,期刊:Journal of Biological Chemistry, 页码:38062-38068 , 文章类型: Article,,卷期:2010年285-49]
- In the natural environment, bacterial cells have to adjust their metabolism to alterations in the availability of food sources. The order and timing of gene expression are crucial in these situations to produce an approp...
- Structural Requirements for Activation in alpha IIb beta 3 Integrin
[作者:Kamata, T; Handa, M; Ito, S; Sato, Y; Ohtani, T; Kawai, Y; Ikeda, Y; Aiso, S,期刊:Journal of Biological Chemistry, 页码:38428-38437 , 文章类型: Article,,卷期:2010年285-49]
- Integrins are postulated to undergo structural rearrangement from a low affinity bent conformer to a high affinity extended conformer upon activation. However, some reports have shown that a bent conformer is capable of ...
- Tay1 Protein, a Novel Telomere Binding Factor from Yarrowia lipolytica
[作者:Kramara, J; Willcox, S; Gunisova, S; Kinsky, S; Nosek, J; Griffith, JD; Tomaska, L,期刊:Journal of Biological Chemistry, 页码:38078-38092 , 文章类型: Article,,卷期:2010年285-49]
- Inspection of the complete genome of the yeast Yarrowia lipolytica for the presence of genes encoding homologues of known telomere-binding proteins surprisingly revealed no counterparts of typical yeast Myb domain-contai...
- Interactions of STAP-2 with Brk and STAT3 Participate in Cell Growth of Human Breast Cancer Cells
[作者:Ikeda, O; Sekine, Y; Mizushima, A; Nakasuji, M; Miyasaka, Y; Yamamoto, C; Muromoto, R; Nanbo, A; Oritani, K; Yoshimura, A; Matsuda, T,期刊:Journal of Biological Chemistry, 页码:38093-38103 , 文章类型: Article,,卷期:2010年285-49]
- STAP-2 (signal transducing adaptor protein-2) is a recently identified adaptor protein that contains pleckstrin homology (PH) and Src homology 2-like domains, as well as a STAT3-binding motif in its C-terminal region. ST...
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