- Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Plays a Key Role in Stellate Cell Activation and Liver Fibrogenesis In Vivo
[作者:Jiang, JX; Venugopal, S; Serizawa, N; Chen, XL; Scott, F; Li, Y; Adamson, R; Devaraj, S; Shah, V; Gershwin, ME; Friedman, SL; Torok, NJ,期刊:Gastroenterology, 页码:1375-1375 , 文章类型: Article,,卷期:2010年139-4]
- BACKGROUND & AIMS: Hepatocyte apoptosis and activation of hepatic stellate cells (HSC) are critical events in fibrogenesis. We previously demonstrated that phagocytosis of apoptotic hepatocytes by HSC is profibrogenic. B...
- FGF Receptors 1 and 2 Control Chemically Induced Injury and Compound Detoxification in Regenerating Livers of Mice
[作者:Bohm, F; Speicher, T; Hellerbrand, C; Dickson, C; Partanen, JM; Ornitz, DM; Werner, S,期刊:Gastroenterology, 页码:1385-1385 , 文章类型: Article,,卷期:2010年139-4]
- BACKGROUND & AIMS: Fibroblast growth factor receptor 4 (FGFR4) controls bile acid metabolism and protects the liver from fibrosis, but the roles of FGFR1 and FGFR2 in the adult liver are largely unknown. We investigated ...
- Akt Phosphorylation of Deleted in Liver Cancer 1 Abrogates Its Suppression of Liver Cancer Tumorigenesis and Metastasis
[作者:Ko, FCF; Chan, LK; Tung, EKK; Lowe, SW; Ng, IOL; Yam, JWP,期刊:Gastroenterology, 页码:1397-1397 , 文章类型: Article,,卷期:2010年139-4]
- BACKGROUND & AIMS: Deleted in liver cancer 1 (DLC1), which encodes a Rho GTPase activating protein, is a bona fide tumor suppressor in hepatocellular carcinoma. Underexpression of DLC1 in cancer has been attributed to ge...
|