- Antitumor activity of (-)-alpha-bisabolol-based thiosemicarbazones against human tumor cell lines
[作者:da Silva, AP; Martini, MV; de Oliveira, CMA; Cunha, S; de Carvalho, JE; Ruiz, ALTG; da Silva, CC,期刊:European Journal of Medicinal Chemistry, 页码:2987-2993 , 文章类型: Article,,卷期:2010年45-7]
- A series of thiosemicarbazones deriving from the natural sesquiterpene (-)-alpha-bisabolol were synthesized and tested against a panel of eight human tumor cell lines to evaluate their anti-tumor potential. Some of the c...
- Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d] Pyrimidine derivatives for their anti-inflammatory and anti-microbial activities
[作者:Mohamed, MS; Kamel, R; Fatahala, SS,期刊:European Journal of Medicinal Chemistry, 页码:2994-3004 , 文章类型: Article,,卷期:2010年45-7]
- The pyrroles la c were used as precursor for the preparation of pyrrolo [2, 3-d] pyrimidine-2 and/or 4 thione derivatives IIa-f. A series of 8-Aryl-pyrrolo [2, 3-d] thiazolo[3,2-a]pyrimidine VI and VII were prepared. Alk...
- Design, synthesis, and pharmacological evaluation of the aqueous prodrugs of desmethyl anethole trithione with hepatoprotective activity
[作者:Chen, P; Luo, Y; Hai, L; Qian, S; Wu, Y,期刊:European Journal of Medicinal Chemistry, 页码:3005-3010 , 文章类型: Article,,卷期:2010年45-7]
- A metabolite-based prodrug strategy to increase the solubility of anethole trithione was reported to facilitate the clinical application of this hepatoprotective agent. Water-soluble analogs of anethole trithione were sy...
- Transition metal complexes of a new hexadentate macroacyclic N2O4-donor Schiff base: Inhibitory activity against bacteria and fungi
[作者:Patil, M; Hunoor, R; Gudasi, K,期刊:European Journal of Medicinal Chemistry, 页码:2981-2986 , 文章类型: Article,,卷期:2010年45-7]
- A new hexadentate macroacyclic N2O4 - donor ligand, glyoxal bis(N-nitroso phenylglycine) (gbnp), has been designed and structurally characterized. Manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes ...
- N,N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents
[作者:Olar, R; Badea, M; Marinescu, D; Chifiriuc, MC; Bleotu, C; Grecu, MN; Iorgulescu, EE; Lazar, V,期刊:European Journal of Medicinal Chemistry, 页码:3027-3034 , 文章类型: Article,,卷期:2010年45-7]
- The new complexes M(DMBG)(2)(ClO4)(2) (M:Mn, Ni, Cu and Zn; DMBG: N,N-dimethylbiguanide) have been synthesized and characterized by IR, EPR, H-1 NMR, C-13 NMR as well as electronic spectroscopy data. Complex [Ni(DMBG)(2)...
- Synthesis and in vitro anticancer screening of some novel 4-[2-amino-3-cyano-4-substituted-5,6,7,8-tetrahydroquinolin-1-(4H)-yl]benzenesulfonamides
[作者:Al-Said, MS; Ghorab, MM; Al-qasoumi, SI; El-Hossary, EM; Noaman, E,期刊:European Journal of Medicinal Chemistry, 页码:3011-3018 , 文章类型: Article,,卷期:2010年45-7]
- It has been reported that aryl/heteroaryl sulfonamide compounds may act as anticancer agents through a variety of mechanisms and the most prominent of these mechanisms is through the inhibition of carbonic anhydrase isoz...
- Synthesis and antioxidant activity evaluation of a syringic hydrazones family
[作者:Belkheiri, N; Bouguerne, B; Bedos-Belval, F; Duran, H; Bemis, C; Salvayre, R; Negre-Salvayre, A; Baltas, M,期刊:European Journal of Medicinal Chemistry, 页码:3019-3026 , 文章类型: Article,,卷期:2010年45-7]
- A novel series of hydrazones derived from syringaldehyde and their antioxidant properties have been explored. Several employed methods such as scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2'-az...
- Synthesis and dual PPAR alpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516
[作者:Ciocoiu, CC; Nikolic, N; Nguyen, HH; Thoresen, GH; Aasen, AJ; Hansen, TV,期刊:European Journal of Medicinal Chemistry, 页码:3047-3055 , 文章类型: Article,,卷期:2010年45-7]
- Ten 1,4-disubstituted 1,2,3-triazoles 2a-2j were prepared and tested for their ability to increase oleic acid oxidation in human myotubes using a high-throughput multiwell assay. Compounds 2e (2-{4-[(1-(3-fluoro-4-(trifl...
- Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cu (II), Ni (II) and Co (II) complexes
[作者:Kumar, G; Kumar, D; Devi, S; Johari, R; Singh, CP,期刊:European Journal of Medicinal Chemistry, 页码:3056-3062 , 文章类型: Article,,卷期:2010年45-7]
- M(II) complexes of the type [HLCu2Cl3], [HLCu2(O(CO)CH3)(3)], [HLM2Cl4(H2O)(3)] and [HLM2(OC(O) CH3)(4)(H2O)(3)], where M = Ni(II), Co(II) have been synthesized by condensation of 3-acyl-2-one indol and hydrazinecarbothi...
- Synthesis and GABA(A) receptor activity of A-homo analogues of neuroactive steroids
[作者:Dansey, MV; Di Chenna, PH; Veleiro, AS; Kristofikova, Z; Chodounska, H; Kasal, A; Burton, G,期刊:European Journal of Medicinal Chemistry, 页码:3063-3069 , 文章类型: Article,,卷期:2010年45-7]
- A procedure is described for the preparation of A-homo-5-pregnenes via an acid catalyzed rearrangement of cyclopropylcarbinols assisted by microwave irradiation. 3 alpha-Hydroxy and 4 alpha-hydroxy-A-homo-5-pregnen-20-on...
- Novel antiviral benzofuran-transition metal complexes
[作者:Galal, SA; Abd El-All, AS; Hegab, KH; Magd-El-Din, AA; Youssef, NS; El-Diwani, HI,期刊:European Journal of Medicinal Chemistry, 页码:3035-3046 , 文章类型: Article,,卷期:2010年45-7]
- (5-(1H-benzo[d]imidazol-2-yl)-1H-pyrrol-3-yl)(6-hydroxy-4,7-dimethoxybenzofuran-5-yl)methanone (4) and 3-(6-hydroxy-4,7-dimethoxybenzofuran-5-carbonyl)-6H-pyrimido[1,6-a]pyrimidine-6,8(7H)-dione (5) were synthesized by t...
- Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4] oxazepine derivatives with anticonvulsant activity
[作者:Deng, XQ; Wei, CX; Li, FN; Sun, ZG; Quan, ZS,期刊:European Journal of Medicinal Chemistry, 页码:3080-3086 , 文章类型: Article,,卷期:2010年45-7]
- A series of novel 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]enzo[f][1,4]oxazepine derivatives were synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test and their neurotoxicity w...
- Synthesis of ruthenium(II) complexes and characterization of their cytotoxicity in vitro, apoptosis, DNA-binding and antioxidant activity
[作者:Liu, YJ; Zeng, CH; Liang, ZH; Yao, JH; Huang, HL; Li, ZZ; Wu, FH,期刊:European Journal of Medicinal Chemistry, 页码:3087-3095 , 文章类型: Article,,卷期:2010年45-7]
- A new ligand DBHIP and its two ruthenium (II) complexes [Ru(bpy)(2)(DBHIP)](ClO4)(2) (1) and [Ru (Phen)2(DBHIP)](ClO4)(2) (2) have been synthesized and characterized. The binding behaviors of the two complexes to calf th...
- Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats
[作者:Hsieh, PW; Yu, HP; Chang, YJ; Hwang, TL,期刊:European Journal of Medicinal Chemistry, 页码:3111-3115 , 文章类型: Article,,卷期:2010年45-7]
- A new series of benzoxazinone analogs were designed, synthesized, and assayed to determine their effects on superoxide anion generation and neutrophil elastase (NE) release in formyl-L-methionyl-L-leucyl-L-phenylalanine ...
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