- Production of hyperpolarized [1,4-C-13(2)]malate from [1,4-C-13(2)]fumarate is a marker of cell necrosis and treatment response in tumors
[作者:Gallagher, FA; Kettunen, MI; Hu, DE; Jensen, PR; in't Zandt, R; Karlsson, M; Gisselsson, A; Nelson, SK; Witney, TH; Bohndiek, SE; Hansson, G; Peitersen, T; Lerche, MH; Brindle, KM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19801-19806 , 文章类型: Article,,卷期:2009年106-47]
- Dynamic nuclear polarization of C-13-labeled cell substrates has been shown to massively increase their sensitivity to detection in NMR experiments. The sensitivity gain is sufficiently large that if these polarized mole...
- The homeotic gene long sterile lemma (G1) specifies sterile lemma identity in the rice spikelet
[作者:Yoshida, A; Suzaki, T; Tanaka, W; Hirano, HY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20103-20108 , 文章类型: Article,,卷期:2009年106-47]
- The mechanism of floral organ specification is principally conserved in angiosperms, as demonstrated by the ABC model. By contrast, mechanisms that regulate the development of organs or structures specific to a group of ...
- Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing
[作者:De Marco, V; Gillespie, PJ; Li, A; Karantzelis, N; Christodoulou, E; Klompmaker, R; van Gerwen, S; Fish, A; Petoukhov, MV; Iliou, MS; Lygerou, Z; Medema, RH; Blow, JJ; Svergun, DI; Taraviras, S; Perrakis, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19807-19812 , 文章类型: Article,,卷期:2009年106-47]
- All organisms need to ensure that no DNA segments are rereplicated in a single cell cycle. Eukaryotes achieve this through a process called origin licensing, which involves tight spatiotemporal control of the assembly of...
- Comparison of Alzheimer A beta(1-40) and A beta(1-42) amyloid fibrils reveals similar protofilament structures
[作者:Schmidt, M; Sachse, C; Richter, W; Xu, C; Fandrich, M; Grigorieff, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19813-19818 , 文章类型: Article,,卷期:2009年106-47]
- We performed mass-per-length (MPL) measurements and electron cryomicroscopy (cryo-EM) with 3D reconstruction on an A beta(1-42) amyloid fibril morphology formed under physiological pH conditions. The data show that the e...
- Local maternal control of seed size by KLUH/CYP78A5-dependent growth signaling
[作者:Adamski, NM; Anastasiou, E; Eriksson, S; O'Neill, CM; Lenhard, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20115-20120 , 文章类型: Article,,卷期:2009年106-47]
- Seed development in plants involves the coordinated growth of the embryo, endosperm, and maternal tissue. Several genes have been identified that influence seed size by acting maternally, such as AUXIN RESPONSE FACTOR2, ...
- Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome
[作者:Wang, DR; Zhang, W; Kalfa, TA; Grabowski, G; Davies, S; Malik, P; Pan, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19958-19963 , 文章类型: Article,,卷期:2009年106-47]
- Restricting transgene expression to maturing erythroid cells can reduce the risk for activating oncogenes in hematopoietic stem cells (HSCs) and their progeny, yet take advantage of their robust protein synthesis machine...
- Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
[作者:Rhein, V; Song, XM; Wiesner, A; Ittner, LM; Baysang, G; Meier, F; Ozmen, L; Bluethmann, H; Drose, S; Brandt, U; Savaskan, E; Czech, C; Gotz, J; Eckert, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20057-20062 , 文章类型: Article,,卷期:2009年106-47]
- Alzheimer's disease (AD) is characterized by amyloid-beta (A beta)-containing plaques, neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been reproduced in P301L tau transgenic pR5 mice, whereas ...
- Precuneus shares intrinsic functional architecture in humans and monkeys
[作者:Margulies, DS; Vincent, JL; Kelly, C; Lohmann, G; Uddin, LQ; Biswal, BB; Villringer, A; Castellanos, FX; Milham, MP; Petrides, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20069-20074 , 文章类型: Article,,卷期:2009年106-47]
- Evidence from macaque monkey tracing studies suggests connectivity-based subdivisions within the precuneus, offering predictions for similar subdivisions in the human. Here we present functional connectivity analyses of ...
- The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system
[作者:Bradaia, A; Trube, G; Stalder, H; Norcross, RD; Ozmen, L; Wettstein, JG; Pinard, A; Buchy, D; Gassmann, M; Hoener, MC; Bettler, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20081-20086 , 文章类型: Article,,卷期:2009年106-47]
- Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids. TAAR1 is considered a promising drug target for the treatment of...
- Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1
[作者:Pani, B; Ong, HL; Brazer, SCW; Liu, XB; Rauser, K; Singh, BB; Ambudkar, IS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20087-20092 , 文章类型: Article,,卷期:2009年106-47]
- Store-operated Ca2+ entry (SOCE) is activated by redistribution of STIM1 into puncta in discrete ER-plasma membrane junctional regions where it interacts with and activates store-operated channels (SOCs). The factors inv...
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