- Galectin-9 Is a High Affinity IgE-binding Lectin with Anti-allergic Effect by Blocking IgE-Antigen Complex Formation
[作者:Niki, T; Tsutsui, S; Hirose, S; Aradono, S; Sugimoto, Y; Takeshita, K; Nishi, N; Hirashima, M,期刊:Journal of Biological Chemistry, 页码:32344-32352 , 文章类型: Article,,卷期:2009年284-47]
- Galectin (Gal)-9 was first described as an eosinophil chemoattractant. With the progress in research, Gal-9 has come to be known as a versatile immunomodulator that is involved in various aspects of immune regulations, a...
- Androgen via p21 Inhibits Tumor Necrosis Factor alpha-induced JNK Activation and Apoptosis
[作者:Tang, FM; Kokontis, J; Lin, YT; Liao, ST; Lin, AN; Xiang, JL,期刊:Journal of Biological Chemistry, 页码:32353-32358 , 文章类型: Article,,卷期:2009年284-47]
- The male hormone androgen is a growth/survival factor for its target tissues or organs. Yet, the underlying mechanism is incompletely understood. Here, we report that androgen via p21 inhibits tumor necrosis factor alpha...
- Characterization of Human Cone Phosphodiesterase-6 Ectopically Expressed in Xenopus laevis Rods
[作者:Muradov, H; Boyd, KK; Haeri, M; Kerov, V; Knox, BE; Artemyev, NO,期刊:Journal of Biological Chemistry, 页码:32662-32669 , 文章类型: Article,,卷期:2009年284-47]
- PDE6 (phosphodiesterase-6) is the effector molecule in the vertebrate phototransduction cascade. Progress in understanding the structure and function of PDE6 has been hindered by lack of an expression system of the enzym...
- Localization, Purification, and Functional Reconstitution of the P-4-ATPase Atp8a2, a Phosphatidylserine Flippase in Photoreceptor Disc Membranes
[作者:Coleman, JA; Kwok, MCM; Molday, RS,期刊:Journal of Biological Chemistry, 页码:32670-32679 , 文章类型: Article,,卷期:2009年284-47]
- P-4-ATPases comprise a relatively new subfamily of P-type ATPases implicated in the energy-dependent translocation of aminophospholipids across cell membranes. In this study, we report on the localization and functional ...
- Membrane Rafts Are Involved in Intracellular Miconazole Accumulation in Yeast Cells
[作者:Francois, IEJA; Bink, A; Vandercappellen, J; Ayscough, KR; Toulmay, A; Schneiter, R; van Gyseghem, E; Van den Mooter, G; Borgers, M; Vandenbosch, D; Coenye, T; Cammue, BPA; Thevissen, K,期刊:Journal of Biological Chemistry, 页码:32680-32685 , 文章类型: Article,,卷期:2009年284-47]
- Azoles inhibit ergosterol biosynthesis, resulting in ergosterol depletion and accumulation of toxic 14 alpha-methylated sterols in membranes of susceptible yeast. We demonstrated previously that miconazole induces actin ...
- JNK and Ceramide Kinase Govern the Biogenesis of Lipid Droplets through Activation of Group IVA Phospholipase A(2)
[作者:Gubern, A; Barcelo-Torns, M; Barneda, D; Lopez, JM; Masgrau, R; Picatoste, F; Chalfant, CE; Balsinde, J; Balboa, MA; Claro, E,期刊:Journal of Biological Chemistry, 页码:32359-32369 , 文章类型: Article,,卷期:2009年284-47]
- The biogenesis of lipid droplets (LD) induced by serum depends on group IVA phospholipase A(2) (cPLA(2)alpha). This work dissects the pathway leading to cPLA(2)alpha activation and LD biogenesis. Both processes were Ca2+...
- Polypyrimidine Tract Binding Protein Prevents Activity of an Intronic Regulatory Element That Promotes Usage of a Composite 3 '-Terminal Exon
[作者:Anquetil, V; Le Sommer, C; Mereau, A; Hamon, S; Lerivray, H; Hardy, S,期刊:Journal of Biological Chemistry, 页码:32370-32383 , 文章类型: Article,,卷期:2009年284-47]
- Alternative splicing of 3'-terminal exons plays a critical role in gene expression by producing mRNA with distinct 3'-untranslated regions that regulate their fate and their expression. The Xenopus alpha-tropomyosin pre-...
- Discovery and Investigation of Misincorporation of Serine at Asparagine Positions in Recombinant Proteins Expressed in Chinese Hamster Ovary Cells
[作者:Wen, DY; Vecchi, MM; Gu, S; Su, LH; Dolnikova, J; Huang, YM; Foley, SF; Garber, E; Pederson, N; Meier, W,期刊:Journal of Biological Chemistry, 页码:32686-32694 , 文章类型: Article,,卷期:2009年284-47]
- Misincorporation of amino acids in proteins expressed in Escherichia coli has been well documented but not in proteins expressed in mammalian cells under normal recombinant protein production conditions. Here we report f...
- A Novel Role for hGas7b in Microtubular Maintenance POSSIBLE IMPLICATION IN TAU-ASSOCIATED PATHOLOGY IN ALZHEIMER DISEASE
[作者:Akiyama, H; Gotoh, A; Shin, RW; Koga, T; Ohashi, T; Sakamoto, W; Harada, A; Arai, H; Sawa, A; Uchida, C; Uchida, T,期刊:Journal of Biological Chemistry, 页码:32695-32699 , 文章类型: Article,,卷期:2009年284-47]
- Here, we report a novel role for hGas7b (human growth arrest specific protein 7b) in the regulation of microtubules. Using a bioinformatic approach, we studied the actin-binding protein hGas7b with a structural similarit...
- Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains
[作者:Ma, L; Xu, MX; Forman, JR; Clarke, J; Oberhauser, AF,期刊:Journal of Biological Chemistry, 页码:32942-32949 , 文章类型: Article,,卷期:2009年284-47]
- Mutations in polycystin-1 (PC1) can cause autosomal dominant polycystic kidney disease, which is a leading cause of renal failure. The available evidence suggests that PC1 acts as a mechanosensor, receiving signals from ...
- Mixed Lineage Kinase Phosphorylates Transcription Factor E47 and Inhibits TrkB Expression to Link Neuronal Death and Survival Pathways
[作者:Pedraza, N; Rafel, M; Navarro, I; Encinas, M; Aldea, M; Gallego, C,期刊:Journal of Biological Chemistry, 页码:32980-32988 , 文章类型: Article,,卷期:2009年284-47]
- E47 is a basic helix-loop-helix transcription factor involved in neuronal differentiation and survival. Wehad previously shown that the basic helix-loop-helix protein E47 binds to E-box sequences within the promoter of t...
- Phosphorylation of Williams Syndrome Transcription Factor by MAPK Induces a Switching between Two Distinct Chromatin Remodeling Complexes
[作者:Oya, H; Yokoyama, A; Yamaoka, I; Fujiki, R; Yonezawa, M; Youn, MY; Takada, I; Kato, S; Kitagawa, H,期刊:Journal of Biological Chemistry, 页码:32472-32482 , 文章类型: Article,,卷期:2009年284-47]
- Changes in the environment of a cell precipitate extracellular signals and sequential cascades of protein modification and elicit nuclear transcriptional responses. However, the functional links between intracellular sig...
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