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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共71条记录   Double Superhelix Model of High Density Lipoprotein [作者：Wu, ZP; Gogonea, V; Lee, X; Wagner, MA; Li, XM; Huang, Y; Undurti, A; May, RP; Haertlein, M; Moulin, M; Gutsche, I; Zaccai, G; DiDonato, JA; Hazen, SL,期刊：Journal of Biological Chemistry, 页码：36605-36619 , 文章类型： Article，,卷期：2009年284-52] High density lipoprotein (HDL), the carrier of so-called "good" cholesterol, serves as the major athero-protective lipoprotein and has emerged as a key therapeutic target for cardiovascular disease. We applied small angl... Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands [作者：Schmidt, A; Harada, SI; Kimmel, DB; Bai, C; Chen, F; Rutledge, SJ; Vogel, RL; Scafonas, A; Gentile, MA; Nantermet, PV; McElwee-Witmer, S; Pennypacker, B; Masarachia, P; Sahoo, SP; Kim, Y; Meissner, RS; Hartman, GD; Duggan, ME; Rodan, GA; Towler, DA; Ray, WJ,期刊：Journal of Biological Chemistry, 页码：36367-36376 , 文章类型： Article，,卷期：2009年284-52] Androgen replacement therapy is a promising strategy for the treatment of frailty; however, androgens pose risks for unwanted effects including virilization and hypertrophy of reproductive organs. Selective Androgen Rece... Cell Adhesion Molecule DdCAD-1 Is Imported into Contractile Vacuoles by Membrane Invagination in a Ca2+- and Conformation-dependent Manner [作者：Sriskanthadevan, S; Lee, T; Lin, Z; Yang, DW; Siu, CH,期刊：Journal of Biological Chemistry, 页码：36377-36386 , 文章类型： Article，,卷期：2009年284-52] The cadA gene in Dictyostelium encodes a Ca2+-dependent cell adhesion molecule DdCAD-1 that contains two beta-sandwich domains. DdCAD-1 is synthesized in the cytoplasm as a soluble protein and then transported by contrac... Transient Receptor Potential Canonical Type 1 (TRPC1) Operates as a Sarcoplasmic Reticulum Calcium Leak Channel in Skeletal Muscle [作者：Berbey, C; Weiss, N; Legrand, C; Allard, B,期刊：Journal of Biological Chemistry, 页码：36387-36394 , 文章类型： Article，,卷期：2009年284-52] Extensive studies performed in nonexcitable cells and expression systems have shown that type 1 transient receptor potential canonical (TRPC1) channels operate mainly in plasma membranes and open through phospholipase C-... Alcadein Cleavages by Amyloid beta-Precursor Protein (APP) alpha- and gamma-Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related gamma-Secretase Dysfunction [作者：Hata, S; Fujishige, S; Araki, Y; Kato, N; Araseki, M; Nishimura, M; Hartmann, D; Saftig, P; Fahrenholz, F; Taniguchi, M; Urakami, K; Akatsu, H; Martins, RN; Yamamoto, K; Maeda, M; Yamamoto, T; Nakaya, T; Gandy, S; Suzuki, T,期刊：Journal of Biological Chemistry, 页码：36024-36033 , 文章类型： Article，,卷期：2009年284-52] Alcadeins (Alcs) constitute a family of neuronal type I membrane proteins, designated Alc(alpha), Alc(beta), and Alc(gamma). The Alcs express in neurons dominantly and largely colocalize with the Alzheimer amyloid precur... Glyphosate Resistance by Engineering the Flavoenzyme Glycine Oxidase [作者：Pedotti, M; Rosini, E; Molla, G; Moschetti, T; Savino, C; Vallone, B; Pollegioni, L,期刊：Journal of Biological Chemistry, 页码：36415-36423 , 文章类型： Article，,卷期：2009年284-52] Glycine oxidase from Bacillus subtilis is a homotetrameric flavoprotein of great potential biotechnological use because it catalyzes the oxidative deamination of various amines and D-isomer of amino acids to yield the co... NTE1-encoded Phosphatidylcholine Phospholipase B Regulates Transcription of Phospholipid Biosynthetic Genes [作者：Fernandez-Murray, JP; Gaspard, GJ; Jesch, SA; McMaster, CR,期刊：Journal of Biological Chemistry, 页码：36034-36046 , 文章类型： Article，,卷期：2009年284-52] The Saccharomyces cerevisiae NTE1 gene encodes an evolutionarily conserved phospholipase B localized to the endoplasmic reticulum (ER) that degrades phosphatidylcholine (PC) generating glycerophosphocholine and free fatt... Polycystin-1 Interacts with Inositol 1,4,5-Trisphosphate Receptor to Modulate Intracellular Ca2+ Signaling with Implications for Polycystic Kidney Disease [作者：Li, Y; Santoso, NG; Yu, SQ; Woodward, OM; Qian, F; Guggino, WB,期刊：Journal of Biological Chemistry, 页码：36431-36441 , 文章类型： Article，,卷期：2009年284-52] The PKD1 or PKD2 genes encode polycystins (PC) 1 and 2, which are associated with polycystic kidney disease. Previously we demonstrated that PC2 interacts with the inositol 1,4,5-trisphosphate receptor (IP3R) to modulate... Conformational Changes Associated with Proton-dependent Gating of ASIC1a [作者：Passero, CJ; Okumura, S; Carattino, MD,期刊：Journal of Biological Chemistry, 页码：36473-36481 , 文章类型： Article，,卷期：2009年284-52] Acid-sensing ion channels are proton-gated Na+ channels expressed predominantly in neurons. How channel structure translates an environmental stimulus into changes in pore permeability remains largely undefined. The pore... A Region within the 5 '-Untranslated Region of Hypoxia-inducible Factor-1 alpha mRNA Mediates Its Turnover in Lung Adenocarcinoma Cells [作者：Wang, MJ; Lin, SK,期刊：Journal of Biological Chemistry, 页码：36500-36510 , 文章类型： Article，,卷期：2009年284-52] Previously, we showed that CL1-5 cells express more hypoxia-inducible factor-1 alpha (HIF-1 alpha) than the parental CL1 cells, which bestows CL1-5 cells a stronger invasive activity. Here, we investigated the mechanisms... Mapping of Disulfide Bonds within the Amino-terminal Extracellular Domain of the Inhibitory Glycine Receptor [作者：Vogel, N; Kluck, CJ; Melzer, N; Schwarzinger, S; Breitinger, U; Seeber, S; Becker, CM,期刊：Journal of Biological Chemistry, 页码：36128-36136 , 文章类型： Article，,卷期：2009年284-52] The strychnine-sensitive glycine receptor (GlyR) is a ligand-gated chloride channel and a member of the superfamily of cysteine loop (Cys-loop) neurotransmitter receptors, which also comprises the nicotinic acetylcholine... GRIN1 Regulates mu-Opioid Receptor Activities by Tethering the Receptor and G Protein in the Lipid Raft [作者：Ge, X; Qiu, Y; Loh, HH; Law, PY,期刊：Journal of Biological Chemistry, 页码：36521-36534 , 文章类型： Article，,卷期：2009年284-52] The lipid raft location of mu-opioid receptor (MOR) determines the receptor activities. However, the manner in which MOR is anchored within the lipid rafts is undetermined. Using the targeted proteomic approach and mass ... Heme Ligand Binding Properties and Intradimer Interactions in the Full-length Sensor Protein Dos from Escherichia coli and Its Isolated Heme Domain [作者：Lechauve, C; Bouzhir-Sima, L; Yamashita, T; Marden, MC; Vos, MH; Lieb, U; Kiger, L,期刊：Journal of Biological Chemistry, 页码：36146-36159 , 文章类型： Article，,卷期：2009年284-52] Dos from Escherichia coli is a bacterial gas sensor protein comprising a heme-containing gas sensor domain and a phosphodiesterase catalytic domain. Using a combination of static light scattering and gel filtration exper... A Turn-like Structure "KKPE" Segment Mediates the Specific Binding of Viral Protein A27 to Heparin and Heparan Sulfate on Cell Surfaces [作者：Shih, PC; Yang, MS; Lin, SC; Ho, Y; Hsiao, JC; Wang, DR; Yu, SSF; Chang, W; Tzou, DLM,期刊：Journal of Biological Chemistry, 页码：36535-36546 , 文章类型： Article，,卷期：2009年284-52] Vaccinia viral envelope protein A27 (110 amino acids) specifically interacts with heparin (HP) or heparan sulfate (HS) proteoglycans for cell surface attachment. To examine the binding mechanism, a truncated soluble form... Structural Insights into the Mechanism of the Allosteric Transitions of Mycobacterium tuberculosis cAMP Receptor Protein [作者：Reddy, MCM; Palaninathan, SK; Bruning, JB; Thurman, C; Smith, D; Sacchettini, JC,期刊：Journal of Biological Chemistry, 页码：36581-36591 , 文章类型： Article，,卷期：2009年284-52] The cAMP receptor protein (CRP) from Mycobacterium tuberculosis is a cAMP-responsive global transcriptional regulator, responsible for the regulation of a multitude of diverse proteins. We have determined the crystal str... Deletion of Tumor Necrosis Factor-alpha Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis [作者：Romanatto, T; Roman, EA; Arruda, AP; Denis, RG; Solon, C; Milanski, M; Moraes, JC; Bonfleur, ML; Degasperi, GR; Picardi, PK; Hirabara, S; Boschero, AC; Curi, R; Velloso, LA,期刊：Journal of Biological Chemistry, 页码：36213-36222 , 文章类型： Article，,卷期：2009年284-52] In diet-induced obesity, hypothalamic and systemic inflammatory factors trigger intracellular mechanisms that lead to resistance to the main adipostatic hormones, leptin and insulin. Tumor necrosis factor-alpha (TNF-alph...