- Through the Looking Glass, Mechanistic Insights from Enantiomeric Human Defensins
[作者:Wei, G; de Leeuw, E; Pazgier, M; Yuan, WR; Zou, GZ; Wang, JF; Ericksen, B; Lu, WY; Lehrer, RI; Lu, WY,期刊:Journal of Biological Chemistry, 页码:29180-29192 , 文章类型: Article,,卷期:2009年284-42]
- Despite the small size and conserved tertiary structure of defensins, little is known at a molecular level about the basis of their functional versatility. For insight into the mechanism(s) of defensin function, we prepa...
- Blom7 alpha Is a Novel Heterogeneous Nuclear Ribonucleoprotein K Homology Domain Protein Involved in Pre-mRNA Splicing That Interacts with SNEVPrp19-Pso4
[作者:Grillari, J; Loscher, M; Denegri, M; Lee, K; Fortschegger, K; Eisenhaber, F; Ajuh, P; Lamond, AI; Katinger, H; Grillari-Voglauer, R,期刊:Journal of Biological Chemistry, 页码:29193-29204 , 文章类型: Article,,卷期:2009年284-42]
- The removal of introns from pre-mRNA is performed by the spliceosome that stepwise assembles on the pre-mRNA before performing two catalytic steps. The spliceosome-associated CDC5L-SNEVPrp19-Pso4 complex is implicated in...
- Pyriform Spidroin 1, a Novel Member of the Silk Gene Family That Anchors Dragline Silk Fibers in Attachment Discs of the Black Widow Spider, Latrodectus hesperus
[作者:Blasingame, E; Tuton-Blasingame, T; Larkin, L; Falick, AM; Zhao, L; Fong, J; Vaidyanathan, V; Visperas, A; Geurts, P; Hu, XY; La Mattina, C; Vierra, C,期刊:Journal of Biological Chemistry, 页码:29097-29108 , 文章类型: Article,,卷期:2009年284-42]
- Spiders spin high performance threads that have diverse mechanical properties for specific biological applications. To better understand the molecular mechanism by which spiders anchor their threads to a solid support, w...
- Critical Role for GATA3 in Mediating Tie2 Expression and Function in Large Vessel Endothelial Cells
[作者:Song, HH; Suehiro, J; Kanki, Y; Kawai, Y; Inoue, K; Daida, H; Yano, K; Ohhashi, T; Oettgen, P; Aird, WC; Kodama, T; Minami, T,期刊:Journal of Biological Chemistry, 页码:29109-29124 , 文章类型: Article,,卷期:2009年284-42]
- Endothelial phenotypes are highly regulated in space and time by both transcriptional and post-transcriptional mechanisms. There is increasing evidence that the GATA family of transcription factors function as signal tra...
- Characterization of Tafazzin Splice Variants from Humans and Fruit Flies
[作者:Xu, Y; Zhang, SL; Malhotra, A; Edelman-Novemsky, I; Ma, JP; Kruppa, A; Cernicica, C; Blais, S; Neubert, TA; Ren, MD; Schlame, M,期刊:Journal of Biological Chemistry, 页码:29230-29239 , 文章类型: Article,,卷期:2009年284-42]
- The tafazzin gene encodes a phospholipid-lysophospholipid transacylase involved in cardiolipin metabolism, but it is not known why it forms multiple transcripts as a result of alternative splicing. Here we studied the in...
- A Novel Pathway of Insulin Sensitivity in Chromogranin A Null Mice A CRUCIAL ROLE FOR PANCREASTATIN IN GLUCOSE HOMEOSTASIS
[作者:Gayen, JR; Saberi, M; Schenk, S; Biswas, N; Vaingankar, SM; Cheung, WW; Najjar, SM; O'Connor, DT; Bandyopadhyay, G; Mahata, SK,期刊:Journal of Biological Chemistry, 页码:28498-28509 , 文章类型: Article,,卷期:2009年284-42]
- Chromogranin A (CHGA/Chga), a proprotein, widely distributed in endocrine and neuroendocrine tissues (not expressed in muscle, liver, and adipose tissues), generates at least four bioactive peptides. One of those peptide...
- Hepatocyte Growth Factor Family Negatively Regulates Hepatic Gluconeogenesis via Induction of Orphan Nuclear Receptor Small Heterodimer Partner in Primary Hepatocytes
[作者:Chanda, D; Li, TG; Song, KH; Kim, YH; Sim, JG; Lee, CH; Chiang, JYL; Choi, HS,期刊:Journal of Biological Chemistry, 页码:28510-28521 , 文章类型: Article,,卷期:2009年284-42]
- Hepatic gluconeogenesis is tightly balanced by opposing stimulatory (glucagon) and inhibitory (insulin) signaling pathways. Hepatocyte growth factor (HGF) is a pleiotropic growth factor that mediates diverse biological p...
- The Tyrosine Sulfate-rich Domains of the LRR Proteins Fibromodulin and Osteoadherin Bind Motifs of Basic Clusters in a Variety of Heparin-binding Proteins, Including Bioactive Factors
[作者:Tillgren, V; Onnerfjord, P; Haglund, L; Heinegard, D,期刊:Journal of Biological Chemistry, 页码:28543-28553 , 文章类型: Article,,卷期:2009年284-42]
- The small leucine-rich repeat proteins, fibromodulin and osteoadherin, have N-terminal extensions with a variable number of O-sulfated tyrosine residues. This modification combined with a number of aspartic and glutamic ...
- GSK-3 Phosphorylates delta-Catenin and Negatively Regulates Its Stability via Ubiquitination/Proteosome-mediated Proteolysis
[作者:Oh, M; Kim, H; Yang, IW; Park, JH; Cong, WT; Baek, MC; Bareiss, S; Ki, H; Lu, Q; No, J; Kwon, I; Choi, JK; Kim, K,期刊:Journal of Biological Chemistry, 页码:28579-28589 , 文章类型: Article,,卷期:2009年284-42]
- delta-Catenin was first identified because of its interaction with presenilin-1, and its aberrant expression has been reported in various human tumors and in patients with Cri-du-Chat syndrome, a form of mental retardati...
- Use of a Riboswitch-controlled Conditional Hypomorphic Mutation to Uncover a Role for the Essential csrA Gene in Bacterial Autoaggregation
[作者:Jin, Y; Watt, RM; Danchin, A; Huang, JD,期刊:Journal of Biological Chemistry, 页码:28738-28745 , 文章类型: Article,,卷期:2009年284-42]
- Essential genes encode biological functions critical for cell survival. Correspondingly, their null mutants are often difficult to obtain, which impedes subsequent genetic and functional analysis. Here, we describe the d...
- Transcriptional Corepressor SMILE Recruits SIRT1 to Inhibit Nuclear Receptor Estrogen Receptor-related Receptor gamma Transactivation
[作者:Xie, YB; Park, JH; Kim, DK; Hwang, JH; Oh, S; Park, SB; Shong, M; Lee, IK; Choi, HS,期刊:Journal of Biological Chemistry, 页码:28762-28774 , 文章类型: Article,,卷期:2009年284-42]
- SMILE (small heterodimer partner interacting leucine zipper protein) has been identified as a corepressor of the glucocorticoid receptor, constitutive androstane receptor, and hepatocyte nuclear factor 4 alpha. Here we s...
- Stereochemical Configuration of 4-Hydroxy-2-nonenal-Cysteine Adducts and Their Stereoselective Formation in a Redox-regulated Protein
[作者:Wakita, C; Maeshima, T; Yamazaki, A; Shibata, T; Ito, S; Akagawa, M; Ojika, M; Yodoi, J; Uchida, K,期刊:Journal of Biological Chemistry, 页码:28810-28822 , 文章类型: Article,,卷期:2009年284-42]
- 4-Hydroxy-2-nonenal (HNE), a major racemic product of lipid peroxidation, preferentially reacts with cysteine residues to form a stable HNE-cysteine Michael addition adduct possessing three chiral centers. Here, to gain ...
- Crosstalk between Protease-activated Receptor 1 and Platelet-activating Factor Receptor Regulates Melanoma Cell Adhesion Molecule (MCAM/MUC18) Expression and Melanoma Metastasis
[作者:Melnikova, VO; Balasubramanian, K; Villares, GJ; Dobroff, AS; Zigler, M; Wang, H; Petersson, F; Price, JE; Schroit, A; Prieto, VG; Hung, MC; Bar-Eli, M,期刊:Journal of Biological Chemistry, 页码:28845-28855 , 文章类型: Article,,卷期:2009年284-42]
- The cellular and molecular pathways that regulate platelet activation, blood coagulation, and inflammation are emerging as critical players in cancer progression and metastasis. Here, we demonstrate a novel signaling mec...
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