- 12-O-Tetradecanoylphorbol-13-acetate Inhibits Melanoma Growth by Inactivation of STAT3 through Protein Kinase C-activated Tyrosine Phosphatase(s)
[作者:Oka, M; Sumita, N; Sakaguchi, M; Iwasaki, T; Bito, T; Kageshita, T; Sato, K; Fukami, Y; Nishigori, C,期刊:Journal of Biological Chemistry, 页码:30416-30423 , 文章类型: Article,,卷期:2009年284-44]
- The growth of most melanoma cells in vitro is inhibited by the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). In this study, the involvement of the signal transducer and activator of transcript...
- Translocator Protein 2 Is Involved in Cholesterol Redistribution during Erythropoiesis
[作者:Fan, JJ; Rone, MB; Papadopoulos, V,期刊:Journal of Biological Chemistry, 页码:30484-30497 , 文章类型: Article,,卷期:2009年284-44]
- Translocator protein (TSPO) is an 18-kDa cholesterol- and drug-binding protein conserved from bacteria to humans. While surveying for Tspo-like genes, we identified its paralogous gene, Tspo2, encoding an evolutionarily ...
- Novel beta-Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial Extension
[作者:Gray, CH; McGarry, LC; Spence, HJ; Riboldi-Tunnicliffe, A; Ozanne, BW,期刊:Journal of Biological Chemistry, 页码:30498-30507 , 文章类型: Article,,卷期:2009年284-44]
- Kelch-related protein 1 (Krp1) is up-regulated in oncogene-transformed fibroblasts. The Kelch repeats interact directly with the actin-binding protein Lasp-1 in membrane ruffles at the tips of pseudopodia, where both pro...
- Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
[作者:Lee, EF; Czabotar, PE; Yang, H; Sleebs, BE; Lessene, G; Colman, PM; Smith, BJ; Fairlie, WD,期刊:Journal of Biological Chemistry, 页码:30508-30517 , 文章类型: Article,,卷期:2009年284-44]
- Antagonists of anti-apoptotic Bcl-2 family members hold promise as cancer therapeutics. Apoptosis is triggered when a peptide containing a BH3 motif or a small molecule BH3 peptidomimetic, such as ABT 737, binds to the r...
- Vimentin Inhibits ATF4-mediated Osteocalcin Transcription and Osteoblast Differentiation
[作者:Lian, N; Wang, WG; Li, LZ; Elefteriou, F; Yang, XL,期刊:Journal of Biological Chemistry, 页码:30518-30525 , 文章类型: Article,,卷期:2009年284-44]
- Activating transcription factor 4 (ATF4) is an osteoblast-enriched transcription factor that regulates osteocalcin transcription and osteoblast terminal differentiation. To identify functional partners of ATF4, we applie...
- Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus
[作者:Spindler, V; Heupel, WM; Efthymiadis, A; Schmidt, E; Eming, R; Rankl, C; Hinterdorfer, P; Muller, T; Drenckhahn, D; Waschke, J,期刊:Journal of Biological Chemistry, 页码:30556-30564 , 文章类型: Article,,卷期:2009年284-44]
- Desmocollin (Dsc) 1-3 and desmoglein (Dsg) 1-4, transmembrane proteins of the cadherin family, form the adhesive core of desmosomes. Here we provide evidence that Dsc3 homo- and heterophilic trans-interaction is crucial ...
- p63 Suppresses Non-epidermal Lineage Markers in a Bone Morphogenetic Protein-dependent Manner via Repression of Smad7
[作者:De Rosa, L; Antonini, D; Ferone, G; Russo, MT; Yu, PB; Han, R; Missero, C,期刊:Journal of Biological Chemistry, 页码:30574-30582 , 文章类型: Article,,卷期:2009年284-44]
- p63, a p53 family member, plays an essential role in epidermal development by regulating its transcriptional program. Here we report a previously uncovered role of p63 in controlling bone morphogenetic protein (BMP) sign...
- Egr-1 Is Necessary for Fibroblast Growth Factor-2-induced Transcriptional Activation of the Glial Cell Line-derived Neurotrophic Factor in Murine Astrocytes
[作者:Shin, SY; Song, H; Kim, CG; Choi, YK; Lee, KS; Lee, SJ; Lee, HJ; Lim, Y; Lee, YH,期刊:Journal of Biological Chemistry, 页码:30583-30593 , 文章类型: Article,,卷期:2009年284-44]
- Glial cell line-derived neurotrophic factor (Gdnf) promotes neurite outgrowth and survival of neuronal cells, but its transcriptional regulation is poorly understood. Here, we sought to investigate the mechanism underlyi...
- The Tail of KdsC CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE
[作者:Biswas, T; Yi, L; Aggarwal, P; Wu, J; Rubin, JR; Stuckey, JA; Woodard, RW; Tsodikov, OV,期刊:Journal of Biological Chemistry, 页码:30594-30603 , 文章类型: Article,,卷期:2009年284-44]
- The phosphatase KdsC cleaves 3-deoxy-D-manno-octulosonate 8-phosphate to generate a molecule of inorganic phosphate and Kdo. Kdo is an essential component of the lipopolysaccharide envelope in Gram-negative bacteria. Bec...
- Aberrant DNA Polymerase alpha Is Excluded from the Nucleus by Defective Import and Degradation in the Nucleus
[作者:Eichinger, CS; Mizuno, T; Mizuno, K; Miyake, Y; Yanagi, K; Imamoto, N; Hanaoka, F,期刊:Journal of Biological Chemistry, 页码:30604-30614 , 文章类型: Article,,卷期:2009年284-44]
- DNA polymerase alpha is essential for the onset of eukaryotic DNA replication. Its correct folding and assembly within the nuclear replication pre-initiation complex is crucial for normal cell cycle progression and genom...
- Speckled-like Pattern in the Germinal Center (SLIP-GC), a Nuclear GTPase Expressed in Activation-induced Deaminase-expressing Lymphomas and Germinal Center B Cells
[作者:Richter, K; Brar, S; Ray, M; Pisitkun, P; Bolland, S; Verkoczy, L; Diaz, M,期刊:Journal of Biological Chemistry, 页码:30652-30661 , 文章类型: Article,,卷期:2009年284-44]
- We identified a novel GTPase, SLIP-GC, with expression limited to a few tissues, in particular germinal center B cells. It lacks homology to any known proteins, indicating that it may belong to a novel family of GTPases....
- Expression Levels of Histone Deacetylases Determine the Cell Fate of Hematopoietic Progenitors
[作者:Wada, T; Kikuchi, J; Nishimura, N; Shimizu, R; Kitamura, T; Furukawa, Y,期刊:Journal of Biological Chemistry, 页码:30673-30683 , 文章类型: Article,,卷期:2009年284-44]
- Histone deacetylases (HDACs) are globally implicated in the growth and differentiation of mammalian cells; however, relatively little is known about their specific roles in hematopoiesis. In this study, we investigated t...
- A Conserved Phosphorylation Site within the Forkhead Domain of FoxM1B Is Required for Its Activation by Cyclin-CDK1
[作者:Chen, YJ; Dominguez-Brauer, C; Wang, ZB; Asara, JM; Costa, RH; Tyner, AL; Lau, LF; Raychaudhuri, P,期刊:Journal of Biological Chemistry, 页码:30695-30707 , 文章类型: Article,,卷期:2009年284-44]
- The Forkhead box M1 (FoxM1) transcription factor is critical for expression of the genes essential for G1/S transition and mitotic progression. To explore the cell cycle regulation of FoxM1, we examined the phosphorylati...
- Regulation of Interdomain Interactions by Calmodulin in Inducible Nitric-oxide Synthase
[作者:Xia, CW; Misra, I; Iyanagi, T; Kim, JJP,期刊:Journal of Biological Chemistry, 页码:30708-30717 , 文章类型: Article,,卷期:2009年284-44]
- Nitric-oxide synthases (NOSs) catalyze the conversion of L-arginine to nitric oxide and citrulline. There are three NOS isozymes, each with a different physiological role: neuronal NOS, endothelial NOS, and inducible NOS...
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