- Adiponectin Inhibits Pro-inflammatory Signaling in Human Macrophages Independent of Interleukin-10
[作者:Folco, EJ; Rocha, VZ; Lopez-Ilasaca, M; Libby, P,期刊:Journal of Biological Chemistry, 页码:25569-25575 , 文章类型: Article,,卷期:2009年284-38]
- Macrophages participate pivotally in the pathogenesis of many chronic inflammatory diseases including atherosclerosis. Adiponectin, a vasculoprotective molecule with insulin-sensitizing and anti-atherogenic properties, s...
- Interaction between HMGA1 and Retinoblastoma Protein Is Required for Adipocyte Differentiation
[作者:Esposito, F; Pierantoni, GM; Battista, S; Melillo, RM; Scala, S; Chieffi, P; Fedele, M; Fusco, A,期刊:Journal of Biological Chemistry, 页码:25993-26004 , 文章类型: Article,,卷期:2009年284-38]
- It is generally accepted that the regulation of adipogenesis prevents obesity. However, the mechanisms controlling adipogenesis have not been completely defined. We have previously demonstrated that HMGA1 proteins play a...
- Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism
[作者:Koliwad, SK; Kuo, TY; Shipp, LE; Gray, NE; Backhed, F; So, AYL; Farese, RV; Wang, JC,期刊:Journal of Biological Chemistry, 页码:25593-25601 , 文章类型: Article,,卷期:2009年284-38]
- Glucocorticoids are important regulators of lipid homeostasis, and chronically elevated glucocorticoid levels induce hypertriglyceridemia, hepatic steatosis, and visceral obesity. The occupied glucocorticoid receptor (GR...
- Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function
[作者:Petrera, NS; Stafford, AR; Leslie, BA; Kretz, CA; Fredenburgh, JC; Weitz, JI,期刊:Journal of Biological Chemistry, 页码:25620-25629 , 文章类型: Article,,卷期:2009年284-38]
- Although exosites 1 and 2 regulate thrombin activity by binding substrates and cofactors and by allosterically modulating the active site, it is unclear whether there is direct allosteric linkage between the two exosites...
- Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues TOWARD GLYCOMICS PROFILING
[作者:Guimond, SE; Puvirajesinghe, TM; Skidmore, MA; Kalus, I; Dierks, T; Yates, EA; Turnbull, JE,期刊:Journal of Biological Chemistry, 页码:25714-25722 , 文章类型: Article,,卷期:2009年284-38]
- Studies on glycosaminoglycans and proteoglycans (PGs) have been hampered by difficulties in isolation and analysis by traditional methods that are laborious and lack sensitivity and throughput. Here we demonstrate a simp...
- Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes SUCCINATION INHIBITS POLYMERIZATION AND SECRETION OF ADIPONECTIN
[作者:Frizzell, N; Rajesh, M; Jepson, MJ; Nagai, R; Carson, JA; Thorpe, SR; Baynes, JW,期刊:Journal of Biological Chemistry, 页码:25772-25781 , 文章类型: Article,,卷期:2009年284-38]
- S-(2-Succinyl) cysteine (2SC) is formed by reaction of the Krebs cycle intermediate fumarate with cysteine residues in protein, a process termed succination of protein. Both fumarate and succination of proteins are incre...
- Dual Acylation of PDE2A Splice Variant 3 TARGETING TO SYNAPTIC MEMBRANES
[作者:Russwurm, C; Zoidl, G; Koesling, D; Russwurm, M,期刊:Journal of Biological Chemistry, 页码:25782-25790 , 文章类型: Article,,卷期:2009年284-38]
- The cGMP-stimulated PDE2A hydrolyzes both cyclic nucleotides, cGMP and cAMP. Three splice variants have been cloned from several species. Whereas PDE2A1 is soluble, PDE2A2 and PDE2A3 are membrane-bound enzymes of rat and...
- Amyloidogenic Potential of Transthyretin Variants INSIGHTS FROM STRUCTURAL AND COMPUTATIONAL ANALYSES
[作者:Cendron, L; Trovato, A; Seno, F; Folli, C; Alfieri, B; Zanotti, G; Berni, R,期刊:Journal of Biological Chemistry, 页码:25832-25841 , 文章类型: Article,,卷期:2009年284-38]
- Human transthyretin (TTR) is an amyloidogenic protein whose mild amyloidogenicity is enhanced by many point mutations affecting considerably the amyloid disease phenotype. To ascertain whether the high amyloidogenic pote...
- Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activation in Vivo and Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway
[作者:Ardi, VC; Van den Steen, PE; Opdenakker, G; Schweighofer, B; Deryugina, EI; Quigley, JP,期刊:Journal of Biological Chemistry, 页码:25854-25866 , 文章类型: Article,,卷期:2009年284-38]
- The structural and catalytic requirements for neutrophil MMP-9 proenzyme (proMMP-9) to induce angiogenesis were investigated using a quantitative angiogenesis model based on grafting of collagen onplants onto the chorioa...
- Increased Cytokine Production in Interleukin-18 Receptor alpha-deficient Cells Is Associated with Dysregulation of Suppressors of Cytokine Signaling
[作者:Nold-Petry, CA; Nold, MF; Nielsen, JW; Bustamante, A; Zepp, JA; Storm, KA; Hong, JW; Kim, SH; Dinarello, CA,期刊:Journal of Biological Chemistry, 页码:25900-25911 , 文章类型: Article,,卷期:2009年284-38]
- Since interleukin (IL)-18 is a proinflammatory cytokine, mice lacking IL-18 or its ligand-binding receptor (IL-18R) should exhibit decreased cytokine and chemokine production. Indeed, production of IL-1 alpha, IL-6, and ...
- Characterization of Mycobacterium leprae RecA Intein, a LAGLIDADG Homing Endonuclease, Reveals a Unique Mode of DNA Binding, Helical Distortion, and Cleavage Compared with a Canonical LAGLIDADG Homing Endonuclease
[作者:Singh, P; Tripathi, P; Silva, GH; Pingoud, A; Muniyappa, K,期刊:Journal of Biological Chemistry, 页码:25912-25928 , 文章类型: Article,,卷期:2009年284-38]
- Mycobacterium leprae, which has undergone reductive evolution leaving behind a minimal set of essential genes, has retained intervening sequences in four of its genes implicating a vital role for them in the survival of ...
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