- Selective G-quadruplex ligands: The significant role of side chain charge density in a series of perylene derivatives
[作者:Micheli, E; Lombardo, CM; D'Ambrosio, D; Franceschin, M; Neidle, S; Savino, M,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3903-3908 , 文章类型: Article,,卷期:2009年19-14]
- The human telomeric G-quadruplex structure is a promising target for the design of cancer drugs. The selectivity of G-quadruplex ligands with respect to duplex genomic DNA is of especial importance. The high selectivity ...
- Positioning of Tc-99m-chelators influences radiolabeling, stability and biodistribution of Affibody molecules
[作者:Ekblad, T; Orlova, A; Feldwisch, J; Wennborg, A; Karlstrom, AE; Tolmachev, V,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3912-3914 , 文章类型: Article,,卷期:2009年19-14]
- Affibody molecules represent a novel class of affinity proteins with a high potential as tracers for radio-nuclide molecular imaging. In this comparative structure-property study, a series of Affibody molecules with the ...
- L-Prolinol as a highly enantioselective catalyst for Michael addition of cyclohexanone to nitroolefins
[作者:Chua, PJ; Tan, B; Zeng, XF; Zhong, GF,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3915-3918 , 文章类型: Article,,卷期:2009年19-14]
- Though many chiral amines such as L-proline and its derivatives have proven to be versatile catalysts in many reactions, L-prolinol was seldom used as organocatalyst for reactions. Herein, we report the first L-prolinol ...
- DNA sequence selectivity of hairpin polyamide turn units
[作者:Farkas, ME; Li, BC; Dose, C; Dervan, PB,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3919-3923 , 文章类型: Article,,卷期:2009年19-14]
- A class of hairpin polyamides linked by 3,4-diaminobutyric acid, resulting in a beta-amine residue at the turn unit, showed improved binding affinities relative to their alpha-amino-gamma-turn analogs for particular sequ...
- Selection of a buried salt bridge by phage display
[作者:Vagt, T; Jackel, C; Samsonov, S; Pisabarro, MT; Koksch, B,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3924-3927 , 文章类型: Article,,卷期:2009年19-14]
- The alpha-helical coiled coil is a valuable folding motif for protein design and engineering. By means of phage display technology, we selected a capable binding partner for one strand of a coiled coil bearing a charged ...
- A new synthesis of caged GABA compounds for studying GABA(A) receptors
[作者:Fan, LJ; Lewis, RW; Hess, GP; Ganem, B,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3932-3933 , 文章类型: Article,,卷期:2009年19-14]
- A short and convergent synthetic approach to new photoactivatable precursors of gamma-aminobutyric acid (GABA) is described. When photolyzed, the 'caged' GABA precursor efficiently releases GABA, as judged by depolarizat...
- Organocatalytic synthesis and sterol 14 alpha-demethylase binding interactions of enantioriched 3-(1H-1,2,4-triazol-1-yl)butyl benzoates
[作者:Ming, ZH; Xu, SZ; Zhou, L; Ding, MW; Yang, JY; Yang, S; Xiao, WJ,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3938-3940 , 文章类型: Article,,卷期:2009年19-14]
- 1H-1,2,4-Triazole reacted with 2-butenal in the presence of diaryl prolinol silyl ether 3 and benzonic acid to give 3-(1H-1,2,4-triazol-1-yl) butanal 4, which was subsequently reduced and then treated with various acyl c...
- Organocatalytic enantioselective hetero-Diels-Alder reaction of aldehydes and o-benzoquinone diimide: Synthesis of optically active hydroquinoxalines
[作者:Li, JL; Han, B; Jiang, K; Du, W; Chen, YC,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:3952-3954 , 文章类型: Article,,卷期:2009年19-14]
- A highly enantioselective inverse electron demand hetero-Diels-Alder reaction of o-benzoquinone diimide and aldehydes has been developed by secondary amine catalysis, giving a facile protocol to access a variety of chira...
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