- Didanosine ester prodrugs: Synthesis, albumin binding properties and pharmacokinetic studies in rats
[作者:Hoyem, S; Bruheim, S; Maelandsmo, G; Standal, M; Olberg, DE; Brudeli, B; Asberg, A; Klaveness, J; Rongved, P,期刊:European Journal of Medicinal Chemistry, 页码:3874-3879 , 文章类型: Article,,卷期:2009年44-10]
- Three half-ester derivatives 10-12 of 5'-O-2',3'-dideoxydidanosine (DDI, 1) have been synthesized. The compounds exhibited excellent correlation between partition coefficients Log P and relative in vitro bovine serum alb...
- Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands
[作者:Laronze-Cochard, M; Kim, YM; Brassart, B; Riou, JF; Laronze, JY; Sapi, J,期刊:European Journal of Medicinal Chemistry, 页码:3880-3888 , 文章类型: Article,,卷期:2009年44-10]
- Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amp...
- Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidine and their antagonistic effects on haloperidol-induced catalepsy and oxidative stress in mice
[作者:Azam, F; Alkskas, IA; Ahmed, MA,期刊:European Journal of Medicinal Chemistry, 页码:3889-3897 , 文章类型: Article,,卷期:2009年44-10]
- A series of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7-yl urea and thiourea derivatives were designed and synthesized. All the compounds have been evaluated for their anti parkinsonian activity in cata...
- Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents
[作者:Jayashankar, B; Rai, KML; Baskaran, N; Sathish, HS,期刊:European Journal of Medicinal Chemistry, 页码:3898-3902 , 文章类型: Article,,卷期:2009年44-10]
- A series of novel ether-linked bis(heterocycle)s have been synthesized via [3 + 2]-cycloaddition reaction of nitrile oxide with allyl alcohol followed by intramolecular 1,3-diploar cycloaddition reaction of nitrite imine...
- Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity
[作者:Kulig, K; Sapa, J; Nowaczyk, A; Filipek, B; Malawska, B,期刊:European Journal of Medicinal Chemistry, 页码:3994-4003 , 文章类型: Article,,卷期:2009年44-10]
- A series of novel arylpiperazines bearing a 3,3-diphenylpyrrolidin-2-one fragment were synthesized and evaluated for their binding affinity for alpha(1)- and alpha(2)-adrenoceptors (ARs), as well as their antiarrhythmic,...
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