- Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones
[作者:Sharma, L; Tsai, YC; Liu, AA; Liu, LF; LaVoie, EJ,期刊:European Journal of Medicinal Chemistry, 页码:1471-1476 , 文章类型: Article,,卷期:2009年44-4]
- Studies on substituted 5H-dibenzo[c,h][1,6]naphthyridin-6-ones and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones have demonstrated that hydrophilic substituents at the 2-position of an ethyl group at the 5- and 6-positions, re...
- 2D-and 3D-QSAR of Tocainide and Mexiletine analogues acting as Na(v)1.4 channel blockers
[作者:Carrieri, A; Muraglia, M; Corbo, F; Pacifico, C,期刊:European Journal of Medicinal Chemistry, 页码:1477-1485 , 文章类型: Article,,卷期:2009年44-4]
- Enantiomeric forms of Tocainide. Mexiletine, and structurally related local anaesthetic compounds, were analyzed with respect to their potency in blocking Na(v)1.4 channel. Structure-activity relationships based on in vi...
- 3D-QSAR studies of boron-containing dipeptides as proteasome inhibitors with CoMFA and CoMSIA methods
[作者:Zhu, YQ; Lei, M; Lu, AJ; Zhao, X; Yin, XJ; Gao, QZ,期刊:European Journal of Medicinal Chemistry, 页码:1486-1499 , 文章类型: Article,,卷期:2009年44-4]
- Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed for a series of dipeptide boronate proteasome inhibitors using comparative molecular field analysis (CoMFA) and comparative ...
- New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity
[作者:Galal, SA; Hegab, KH; Kassab, AS; Rodriguez, ML; Kerwin, SM; El-Khamry, AMA; El Diwani, HI,期刊:European Journal of Medicinal Chemistry, 页码:1500-1508 , 文章类型: Article,,卷期:2009年44-4]
- Metal complexes of 2-methyl-1H-benzimidazole-5-carboxylic acid hydrazide (4a; L-1) and its Schiff base 2-methyl-N-(propan-2-ylidene)-1H-benzimidazole-5-carbohydrazide (5a; L-2) with transition metal ions e.g., copper, si...
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