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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共76条记录   Synthesis of four novel natural product inspired scaffolds for drug discovery. [作者：Jenkins, Ian D.;Lacrampe, Fabienne;Ripper, Justin;Alcaraz, Lilian;Van Le, Phuc;Nikolakopoulos, George;de Almeida Leone, Priscila;White, Rodney H.;Quinn, Ronald J.;,期刊：Journal of Organic Chemistry, 页码：1304-1313 , 文章类型： 研究论文，,卷期：2009年74-3] Inspired by the spiro structures of a no. of bioactive natural products such as the histrionicotoxins, a series of spiro scaffolds have been designed and robust syntheses developed. The scaffolds are ready-to-use buildi... Direct Dehydrative N-Pyridinylation of Amides. [作者：Medley, Jonathan William;Movassaghi, Mohammad;,期刊：Journal of Organic Chemistry, 页码：1341-1344 , 文章类型： 研究论文，,卷期：2009年74-3] Electrophilic activation of secondary amides with trifluoromethanesulfonic anhydride in the presence of 2-fluoropyridine followed by introduction of a pyridine N-oxide deriv. and warming affords the corresponding N-pyrid... Tandem b-enamino ester formation and cyclization with o-alkynyl anilines catalyzed by InBr3: efficient synthesis of b-(N-indolyl)-a,b-unsaturated esters. [作者：Murai, Kenichi;Hayashi, Shoko;Takaichi, Nobuhiro;Kita, Yasuyuki;Fujioka, Hiromichi;,期刊：Journal of Organic Chemistry, 页码：1418-1421 , 文章类型： 研究论文，,卷期：2009年74-3] A tandem reaction providing b-(N-indolyl)-a,b-unsatd. esters from b-keto esters and o-alkynyl anilines was developed. Z-Alkenes were selectively formed due to the stability of the b-enamino ester as an intermediate of t... Microwave-Assisted Intramolecular Huisgen Cycloaddition of Azido Alkynes Derived from a-Amino Acids. [作者：Balducci, Evita;Bellucci, Luca;Petricci, Elena;Taddei, Maurizio;Tafi, Andrea;,期刊：Journal of Organic Chemistry, 页码：1314-1321 , 文章类型： 研究论文，,卷期：2009年74-3] The intramol. version of the Huisgen cycloaddn. is a potentially useful reaction for the stereocontrolled prepn. of 1,5-disubstituted and 1,4,5-trisubstiututed triazoles. When a-azido propargyl esters derived from a-ami... Ru-TsDPEN with Formic Acid/Hunig's Base for Asymmetric Transfer Hydrogenation, a Practical Synthesis of Optically Enriched N-Propyl Pantolactam. [作者：Zhang, Ji;Blazecka, Peter G.;Bruendl, Michelle M.;Huang, Yun;,期刊：Journal of Organic Chemistry, 页码：1411-1414 , 文章类型： 研究论文，,卷期：2009年74-3] The Noyori-Ikariya catalysts, Ru-TsDPEN in combination with HCOOH/Hunig's base (5:2) have been successfully utilized for catalytic asym. transfer hydrogenation of a-ketopantolactam, and optically enriched N-substituted p... Diastereoselective Preparation of Substituted d-Valerolactones. [作者：Synthesis of;,期刊：Journal of Organic Chemistry, 页码：1360-1363 , 文章类型： 研究论文，,卷期：2009年74-3] The syntheses of simplactones A and B I and II, resp., were achieved in 5 steps from N-acyl thiazolidinethione chiral auxiliaries. The syntheses feature a double diastereoselective acetate aldol reaction solely controll... 3-Aryltetronic Acids: Efficient Preparation and Use as Precursors for Vulpinic Acids. [作者：Mallinger, Aurelie;Le Gall, Thierry;Mioskowski, Charles;,期刊：Journal of Organic Chemistry, 页码：1124-1129 , 文章类型： 研究论文，,卷期：2009年74-3] 3-Aryltetronic acids were prepd. in one step by treatment of a mixt. of Me arylacetates and Me hydroxyacetates with potassium tert-butoxide, via tandem transesterification/Dieckmann condensation. Several mushroom or lic... Remote stereocontrol mediated by a sulfinyl group: synthesis of allylic alcohols via chemoselective and diastereoselective reduction of g-methylene d-ketosulfoxides. [作者：Garcia Ruano, Jose L.;Angeles Fernandez-Ibanez, M.;Fernandez-Salas, Jose A.;Maestro, M. Carmen;Marquez-Lopez, Pablo;Mercedes Rodriguez-Fernandez, M.;,期刊：Journal of Organic Chemistry, 页码：1200-1204 , 文章类型： 研究论文，,卷期：2009年74-3] The efficiency of the sulfinyl group as a remote controller of the chemoselectivity and diastereoselectivity of the redn. of a,b-unsatd. a-[2-(p-tolylsulfinyl)phenyl] substituted ketones has been demonstrated in reaction... Polymer-Immobilized Catalyst for Asymmetric Hydrogenation of Racemic a-(N-Benzoyl-N-methylamino)propiophenone. [作者：Chiwara, Vinia Ipai;Haraguchi, Naoki;Itsuno, Shinichi;,期刊：Journal of Organic Chemistry, 页码：1391-1393 , 文章类型： 研究论文，,卷期：2009年74-3] Asym. hydrogenation of a-(N-benzoyl-N-methylamino)propiophenone through dynamic kinetic resoln. was performed by using a polymer-immobilized chiral diamine-ruthenium-BINAP-t-BuOK system. This method yield syn-b-amide alc... Triplet Photochemistry of Vinyl Cyclopropenes: Mechanistic and Exploratory Organic Photochemistry. [作者：Zimmerman, Howard E.;,期刊：Journal of Organic Chemistry, 页码：1247-1251 , 文章类型： 研究论文，,卷期：2009年74-3] Research on the triplet photochem. of vinylcyclopropenes has dealt with a diverse series of systems, providing exptl. examples and mechanistic studies. It perhaps is not surprising that the reaction mechanisms were cont... Competition Studies in Alkyne Electrophilic Cyclization Reactions. [作者：Mehta, Saurabh;Waldo, Jesse P.;Larock, Richard C.;,期刊：Journal of Organic Chemistry, 页码：1141-1147 , 文章类型： 研究论文，,卷期：2009年74-3] The relative reactivity of various functional groups toward alkyne electrophilic cyclization reactions has been studied. The required diarylalkynes have been prepd. by consecutive Sonogashira reactions of appropriately ... Structure, Stereodynamics and Absolute Configuration of the Atropisomers of Hindered Arylanthraquinones. [作者：Lunazzi, Lodovico;Mancinelli, Michele;Mazzanti, Andrea;,期刊：Journal of Organic Chemistry, 页码：1345-1348 , 文章类型： 研究论文，,卷期：2009年74-3] Anthraquinone substituted by 2-methyl-1-naphthyl groups in positions 1,8 yields syn (meso) and anti (racemic) isomers (red and yellow colored, resp.) that interconvert with a barrier of 35.4 kcal mol-1 in soln. Their str... A Preparatively Convenient Ligand-Free Catalytic PEG 2000 Suzuki-Miyaura Coupling. [作者：Razler, Thomas M.;Hsiao, Yi;Qian, Feng;Fu, Ruiling;Khan, Rana Kashif;Doubleday, Wendel;,期刊：Journal of Organic Chemistry, 页码：1381-1384 , 文章类型： 研究论文，,卷期：2009年74-3] A ligand-free Suzuki-Miyaura reaction for the cross-coupling of aryl and heteroaryl bromides with aryl and heteroarylboronic acids has been developed utilizing catalytic polyethylene glycol 2000 (PEG 2000). This prepara... Isolation, Structure Elucidation, and Synthesis of Eudistomides A and B, Lipopeptides from a Fijian Ascidian Eudistoma sp. [作者：Whitson, Emily L.;Ratnayake, Anokha S.;Bugni, Tim S.;Harper, Mary Kay;Ireland, Chris M.;,期刊：Journal of Organic Chemistry, 页码：1156-1162 , 文章类型： 研究论文，,卷期：2009年74-3] Eudistomides A (I) and B (II), two new cyclic peptides, were isolated from a Fijian ascidian Eudistoma sp. These five-residue cystine-linked cyclic peptides are flanked by a C-terminal Me ester and a 12-oxo- or 12-hydro... Synthetic Approaches to the Microtubule-Stabilizing Sponge Alkaloid Ceratamine A and Desbromo Analogues. [作者：Nodwell, Matt;Pereira, Alban;Riffell, Jenna L.;Zimmerman, Carla;Patrick, Brian O.;Roberge, Michel;Andersen, Raymond J.;,期刊：Journal of Organic Chemistry, 页码：995-1006 , 文章类型： 研究论文，,卷期：2009年74-3] Two synthetic approaches to the microtubule-stabilizing ceratamine alkaloids are described. The first approach involved attempts to graft an aminoimidazole moiety onto an azepine ring to form partially hydrogenated vers... Functionalized 2'-Amino-a-L-LNA: Directed Positioning of Intercalators for DNA Targeting. [作者：Kumar, T. Santhosh;Madsen, Andreas S.;Ostergaard, Michael E.;Sau, Sujay P.;Wengel, Jesper;Hrdlicka, Patrick J.;,期刊：Journal of Organic Chemistry, 页码：1070-1081 , 文章类型： 研究论文，,卷期：2009年74-3] Chem. modified oligonucleotides are increasingly applied in nucleic acid based therapeutics and diagnostics. LNA (locked nucleic acid) and its diastereomer a-L-LNA are two promising examples thereof that exhibit increas...