- Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV
[作者:Nakajima, Y; Imanishi, M; Itou, S; Hamashima, H; Tomishima, Y; Washizuka, K; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Hattori, K,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5037-5040 , 文章类型: Article,,卷期:2008年18-18]
- Identification and SAR study of novel series of beta(3)-AR agonists with benzoic acid are described. Conversion of ether linkage position of phenoxybenzoic acid derivative 2b led to compound 7b with moderate b(3)-AR acti...
- Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization
[作者:Romagnoli, R; Baraldi, PG; Carrion, MD; Cruz-Lopez, O; Cara, CL; Tolomeo, M; Grimaudo, S; Di Cristina, A; Pipitone, MR; Balzarini, J; Kandil, S; Brancale, A; Sarkar, T; Hamel, E,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5041-5045 , 文章类型: Article,,卷期:2008年18-18]
- Microtubules are among the most successful targets of compounds potentially useful for cancer therapy. A new series of inhibitors of tubulin polymerization based on the 2-amino-3-(3,4,5-trimethoxybenzoyl)-4,5,6,7-tetrahy...
- Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-kappa B-, AP-1-, or CREB-mediated transcription
[作者:Huang, ST; Lee, YS; Gullen, EA; Cheng, YC,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5046-5049 , 文章类型: Article,,卷期:2008年18-18]
- The water extract of Scutellariae baicalensis Georgi ( S. baicalensis) has potential anti-tumor and anti-inflammatory activities. A major flavonoid isolated from S. baicalensis, baicalein, was also found to have anti-tum...
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