- Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates
[作者:Fang, L; Kraus, B; Lehmann, J; Heilmann, J; Zhang, YH; Decker, M,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2905-2909 , 文章类型: Article,,卷期:2008年18-9]
- Five tacrine-ferulic acid hybrids (6a-e) were designed and synthesized as multi-potent anti-Alzheimer drug candidates. All target compounds have better acetylcholinesterase inhibitory activity and comparable butyrylcholi...
- E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation
[作者:Giannini, G; Marzi, M; Cabri, W; Marastoni, E; Battistuzzi, G; Vesci, L; Pisano, C; Beretta, GL; De Cesare, M; Zunino, F,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:2910-2915 , 文章类型: Article,,卷期:2008年18-9]
- In contrast to five-membered E-ring analogues, 7-oxyiminomethyl derivatives of homocamptothecins showed ability to form stable ternary complexes with DNA and topoisomerase I. The 7-oxyiminomethyl derivatives of homocampt...
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