- Saccharomyces cerevisiae MutL alpha is a mismatch repair endonuclease
[作者:Kadyrov, FA; Holmes, SF; Arana, ME; Lukianova, OA; O'Donnell, M; Kunkel, TA; Modrich, P,期刊:Journal of Biological Chemistry, 页码:37181-37190 , 文章类型: Article,,卷期:2007年282-51]
- MutL homologs are crucial for mismatch repair and genetic stability, but their function is not well understood. Human MutL alpha (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on the integrity of...
- Cell type-specific functions of the lysosomal protease cathepsin L in the heart
[作者:Spira, D; Stypmann, J; Tobin, DJ; Petermann, I; Mayer, C; Hagemann, S; Vasiljeva, O; Gunther, T; Schule, R; Peters, C; Reinheckel, T,期刊:Journal of Biological Chemistry, 页码:37045-37052 , 文章类型: Article,,卷期:2007年282-51]
- Deficiency of the lysosomal cysteine protease cathepsin L (Ctsl) in mice results in a phenotype affecting multiple tissues, including thymus, epidermis, and hair follicles, and in the heart develops as a progressive dila...
- Crystal structure of the interleukin-15 center dot interleukin-15 receptor alpha complex - Insights into trans and cis presentation
[作者:Olsen, SK; Ota, N; Kishishita, S; Kukimoto-Niino, M; Murayama, K; Uchiyama, H; Toyama, M; Terada, T; Shirouzu, M; Kanagawa, O; Yokoyama, S,期刊:Journal of Biological Chemistry, 页码:37191-37204 , 文章类型: Article,,卷期:2007年282-51]
- Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans signaling mechanism in which IL-15 recepto...
- Controlling the inhibition of the sarcoplasmic Ca2+-ATPase by tuning phospholamban structural dynamics
[作者:Ha, KN; Traaseth, NJ; Verardi, R; Zamoon, J; Cembran, A; Karim, CB; Thomas, DD; Veglia, G,期刊:Journal of Biological Chemistry, 页码:37205-37214 , 文章类型: Article,,卷期:2007年282-51]
- Cardiac contraction and relaxation are regulated by conformational transitions of protein complexes that are responsible for calcium trafficking through cell membranes. Central to the muscle relaxation phase is a dynamic...
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