- Auto-hydroxylation of FIH-1: an Fe(II), a-ketoglutarate-dependent human hypoxia sensor.
[作者:Chen, Yuan-Han;Comeaux, Lindsay M.;Eyles, Stephen J.;Knapp, Michael J.;,期刊:Chemical Communications, 页码:4768-4770 , 文章类型: 研究论文,,卷期:2008年-39]
- HIF-asparaginyl hydroxylase (FIH-1) normally couples O2-activation to hydroxylation of Asn803 on the a-subunit of the hypoxia-inducible factor (HIFa), a key step in pO2 sensing; in the absence of HIFa, O2-activation beco...
|