- Compartmentalization of Phosphatidylinositol 4,5-Bisphosphate Signaling Evidenced Using Targeted Phosphatases
[作者:Johnson, CM; Chichili, GR; Rodgers, W,期刊:Journal of Biological Chemistry, 页码:29920-29928 , 文章类型: Article,,卷期:2008年283-44]
- Phosphatidylinositol 4,5-bisphosphate (PIP2) is a prevalent phosphoinositide in cell membranes, with important functions in cell signaling and activation. A large fraction of PIP2 associates with the detergent-resistant ...
- Nck Adapters Are Involved in the Formation of Dorsal Ruffles, Cell Migration, and Rho Signaling Downstream of the Platelet-derived Growth Factor beta Receptor
[作者:Ruusala, A; Pawson, T; Heldin, CH; Aspenstrom, P,期刊:Journal of Biological Chemistry, 页码:30034-30044 , 文章类型: Article,,卷期:2008年283-44]
- The SH3 and SH2 domain-containing adapter proteins Nck1 and Nck2 are known to function downstream of activated tyrosine kinase receptors, such as the platelet-derived growth factor (PDGF) receptors. The SH2 domain of Nck...
- Structure of Human J-type Co-chaperone HscB Reveals a Tetracysteine Metal-binding Domain
[作者:Bitto, E; Bingman, CA; Bittova, L; Kondrashov, DA; Bannen, RM; Fox, BG; Markley, JL; Phillips, GN,期刊:Journal of Biological Chemistry, 页码:30184-30192 , 文章类型: Article,,卷期:2008年283-44]
- Iron-sulfur proteins play indispensable roles in a broad range of biochemical processes. The biogenesis of iron-sulfur proteins is a complex process that has become a subject of extensive research. The final step of iron...
- Fibrinogen-elongated gamma Chain Inhibits Thrombin-induced Platelet Response, Hindering the Interaction with Different Receptors
[作者:Lancellotti, S; Rutella, S; De Filippis, V; Pozzi, N; Rocca, B; De Cristofaro, R,期刊:Journal of Biological Chemistry, 页码:30193-30204 , 文章类型: Article,,卷期:2008年283-44]
- The expression of the elongated fibrinogen gamma chain, termed gamma', derives from alternative splicing of mRNA and causes an insertion sequence of 20 amino acids. This insertion domain interacts with the anion-binding ...
- Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor alpha Chain
[作者:Rousseau, F; Chevalier, S; Guillet, C; Ravon, E; Diveu, C; Froger, J; Barbier, F; Grimaud, L; Gascan, H,期刊:Journal of Biological Chemistry, 页码:30341-30350 , 文章类型: Article,,卷期:2008年283-44]
- Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin are members of the four-helix bundle cytokine family. These proteins signal through a common tripartite receptor composed of leukemia inhibitory ...
- Rac Regulates Its Effector Phospholipase C gamma(2) through Interaction with a Split Pleckstrin Homology Domain
[作者:Walliser, C; Retlich, M; Harris, R; Everett, KL; Josephs, MB; Vatter, P; Esposito, D; Driscoll, PC; Katan, M; Gierschik, P; Bunney, TD,期刊:Journal of Biological Chemistry, 页码:30351-30362 , 文章类型: Article,,卷期:2008年283-44]
- Several isoforms of phospholipase C (PLC) are regulated through interactions with Ras superfamily GTPases, including Rac proteins. Interestingly, of two closely related PLC gamma isoforms, only PLC gamma(2) has previousl...
- Up-regulating Sphingosine 1-Phosphate Receptor-2 Signaling Impairs Chemotactic, Wound-healing, and Morphogenetic Responses in Senescent Endothelial Cells
[作者:Estrada, R; Zeng, Q; Lu, HW; Sarojini, H; Lee, JF; Mathis, SP; Sanchez, T; Wang, E; Kontos, CD; Lin, CY; Hla, T; Haribabu, B; Lee, MJ,期刊:Journal of Biological Chemistry, 页码:30363-30375 , 文章类型: Article,,卷期:2008年283-44]
- Vascular endothelial cells (ECs) have a finite lifespan when cultured in vitro and eventually enter an irreversible growth arrest state called "cellular senescence." It has been shown that sphingo-lipids may be involved ...
- Rationally Designed Anti-HIV Peptides Containing Multifunctional Domains as Molecule Probes for Studying the Mechanisms of Action of the First and Second Generation HIV Fusion Inhibitors
[作者:Qi, Z; Shi, WG; Xue, N; Pan, CG; Jing, WG; Liu, KL; Jiang, SB,期刊:Journal of Biological Chemistry, 页码:30376-30384 , 文章类型: Article,,卷期:2008年283-44]
- We have previously shown that the first generation human immunodeficiency virus (HIV) fusion inhibitor T20 (Fuzeon) contains a critical lipid-binding domain (LBD), whereas C34, another anti-HIV peptide derived from the g...
- The Diversity of O-Linked Glycans Expressed during Drosophila melanogaster Development Reflects Stage- and Tissue-specific Requirements for Cell Signaling
[作者:Aoki, K; Porterfield, M; Lee, SS; Dong, B; Nguyen, K; McGlamry, KH; Tiemeyer, M,期刊:Journal of Biological Chemistry, 页码:30385-30400 , 文章类型: Article,,卷期:2008年283-44]
- Appropriate glycoprotein O-glycosylation is essential for normal development and tissue function in multicellular organisms. To comprehensively assess the developmental and functional impact of altered O-glycosylation, w...
- Structural Basis for a Distinct Catalytic Mechanism in Trypanosoma brucei Tryparedoxin Peroxidase
[作者:Melchers, J; Diechtierow, M; Feher, K; Sinning, I; Tews, I; Krauth-Siegel, RL; Muhle-Goll, C,期刊:Journal of Biological Chemistry, 页码:30401-30411 , 文章类型: Article,,卷期:2008年283-44]
- Trypanosoma brucei, the causative agent of African sleeping sickness, encodes three cysteine homologues (Px I-III) of classical selenocysteine-containing glutathione peroxidases. The enzymes obtain their reducing equival...
- Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species
[作者:Du, JQ; Wu, J; Zhang, HJ; Zhang, YH; Qiu, BY; Wu, F; Chen, YH; Li, JY; Nan, FJ; Ding, JP; Li, J,期刊:Journal of Biological Chemistry, 页码:30205-30215 , 文章类型: Article,,卷期:2008年283-44]
- Caspase-3 is an attractive therapeutic target for treatment of diseases involving disregulated apoptosis. We report here the mechanism of caspase-3 inactivation by isoquinoline-1,3,4-trione derivatives. Kinetic analysis ...
- Multiple Mechanisms Contribute to Schizosaccharomyces pombe Origin Recognition Complex-DNA Interactions
[作者:Houchens, CR; Lu, WY; Chuang, RY; Frattini, MG; Fuller, A; Simancek, P; Kelly, TJ,期刊:Journal of Biological Chemistry, 页码:30216-30224 , 文章类型: Article,,卷期:2008年283-44]
- Eukaryotic DNA replication requires the assembly of multiprotein pre-replication complexes (pre-RCs) at chromosomal origins of DNA replication. Here we describe the interactions of highly purified Schizosaccharomyces pom...
- Functional Adhesiveness of the CX3CL1 Chemokine Requires Its Aggregation ROLE OF THE TRANSMEMBRANE DOMAIN
[作者:Hermand, P; Pincet, F; Carvalho, S; Ansanay, H; Trinquet, E; Daoudi, M; Combadiere, C; Deterre, P,期刊:Journal of Biological Chemistry, 页码:30225-30234 , 文章类型: Article,,卷期:2008年283-44]
- In its native form, the chemokine CX3CL1 is a firmly adhesive molecule promoting leukocyte adhesion and migration and hence involved, along with its unique receptor CX3CR1, in various inflammatory processes. Here we inve...
- Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils
[作者:Gijon, MA; Riekhof, WR; Zarini, S; Murphy, RC; Voelker, DR,期刊:Journal of Biological Chemistry, 页码:30235-30245 , 文章类型: Article,,卷期:2008年283-44]
- The cycle of deacylation and reacylation of phospholipids plays a critical role in regulating availability of arachidonic acid for eicosanoid production. The major yeast lysophospholipid acyltransferase, Ale1p, is relate...
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