- The Structure of FSTL3.Activin A Complex DIFFERENTIAL BINDING OF N-TERMINAL DOMAINS INFLUENCES FOLLISTATIN-TYPE ANTAGONIST SPECIFICITY
[作者:Stamler, R; Keutmann, HT; Sidis, Y; Kattamuri, C; Schneyer, A; Thompson, TB,期刊:Journal of Biological Chemistry, 页码:32831-32838 , 文章类型: Article,,卷期:2008年283-47]
- Transforming growth factor beta family ligands are neutralized by a number of structurally divergent antagonists. Follistatin-type antagonists, which include splice variants of follistatin (FS288 and FS315) and follistat...
- Crystal Structures of the Choline/Acetylcholine Substrate-binding Protein ChoX from Sinorhizobium meliloti in the Liganded and Unliganded-Closed States
[作者:Oswald, C; Smits, SHJ; Hoing, M; Sohn-Bosser, L; Dupont, L; Le Rudulier, D; Schmitt, L; Bremer, E,期刊:Journal of Biological Chemistry, 页码:32848-32859 , 文章类型: Article,,卷期:2008年283-47]
- The ATP-binding cassette transporter ChoVWX is one of several choline import systems operating in Sinorhizobium meliloti. Here fluorescence-based ligand binding assays were used to quantitate substrate binding by the per...
- Probing the Interaction between the Coiled Coil Leucine Zipper of cGMP-dependent Protein Kinase I alpha and the C Terminus of the Myosin Binding Subunit of the Myosin Light Chain Phosphatase
[作者:Sharma, AK; Zhou, GP; Kupferman, J; Surks, HK; Christensen, EN; Chou, JJ; Mendelsohn, ME; Rigby, AC,期刊:Journal of Biological Chemistry, 页码:32860-32869 , 文章类型: Article,,卷期:2008年283-47]
- Nitric oxide and nitrovasodilators induce vascular smooth muscle cell relaxation in part by cGMP-dependent protein kinase I (PKG-I alpha)-mediated activation of myosin phosphatase (MLCP). Mechanistically it has been prop...
- Actin Binding by Hip1 (Huntingtin-interacting Protein 1) and Hip1R (Hip1-related Protein) Is Regulated by Clathrin Light Chain
[作者:Wilbur, JD; Chen, CY; Manalo, V; Hwang, PK; Fletterick, RJ; Brodsky, FM,期刊:Journal of Biological Chemistry, 页码:32870-32879 , 文章类型: Article,,卷期:2008年283-47]
- The huntingtin-interacting protein family members (Hip1 and Hip1R in mammals and Sla2p in yeast) link clathrin-mediated membrane traffic to actin cytoskeleton dynamics. Genetic data in yeast have implicated the light cha...
- Catalytically Active Monomer of Glutathione S-Transferase pi and Key Residues Involved in the Electrostatic Interaction between Subunits
[作者:Huang, YC; Misquitta, S; Blond, SY; Adams, E; Colman, RF,期刊:Journal of Biological Chemistry, 页码:32880-32888 , 文章类型: Article,,卷期:2008年283-47]
- Human glutathione transferase pi (GST pi) has been crystallized as a homodimer, with a subunit molecular mass of similar to 23 kDa; however, in solution the average molecular mass depends on protein concentration, approa...
- Erythrocytic Adenosine Monophosphate as an Alternative Purine Source in Plasmodium falciparum'
[作者:Cassera, MB; Hazleton, KZ; Riegelhaupt, PM; Merino, EF; Luo, MK; Akabas, MH; Schramm, VL,期刊:Journal of Biological Chemistry, 页码:32889-32899 , 文章类型: Article,,卷期:2008年283-47]
- Plasmodium falciparum is a purine auxotroph, salvaging purines from erythrocytes for synthesis of RNA and DNA. Hypoxanthine is the key precursor for purine metabolism in Plasmodium. Inhibition of hypoxanthine-forming rea...
- Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1
[作者:Pioszak, AA; Parker, NR; Suino-Powell, K; Xu, HE,期刊:Journal of Biological Chemistry, 页码:32900-32912 , 文章类型: Article,,卷期:2008年283-47]
- The bimolecular interaction between corticotropin-releasing factor (CRF), a neuropeptide, and its type 1 receptor (CRFR1), a class B G-protein-coupled receptor (GPCR), is crucial for activation of the hypothalamic-pituit...
- Conserved Polar Residues in Transmembrane Domains V, VI, and VII of Free Fatty Acid Receptor 2 and Free Fatty Acid Receptor 3 Are Required for the Binding and Function of Short Chain Fatty Acids
[作者:Stoddart, LA; Smith, NJ; Jenkins, L; Brown, AJ; Milligan, G,期刊:Journal of Biological Chemistry, 页码:32913-32924 , 文章类型: Article,,卷期:2008年283-47]
- FFA2 and FFA3 are closely related G protein-coupled receptors that bind and respond to short chain fatty acids. (FFA2 and FFA3 are the provisional International Union of Pharmacology designations for the receptors previo...
- The Stability of the Ternary Interferon-Receptor Complex Rather than the Affinity to the Individual Subunits Dictates Differential Biological Activities
[作者:Kalie, E; Jaitin, DA; Podoplelova, Y; Piehler, J; Schreiber, G,期刊:Journal of Biological Chemistry, 页码:32925-32936 , 文章类型: Article,,卷期:2008年283-47]
- Type I interferons (IFNs) signal for their diverse biological effects by binding a common receptor on target cells, composed of the two transmembrane IFNAR1 and IFNAR2 proteins. We have previously differentially enhanced...
- ErbB4-Neuregulin Signaling Modulates Synapse Development and Dendritic Arborization through Distinct Mechanisms
[作者:Krivosheya, D; Tapia, L; Levinson, JN; Huang, K; Kang, Y; Hines, R; Ting, AK; Craig, AM; Mei, L; Bamji, SX; El-Husseini, A,期刊:Journal of Biological Chemistry, 页码:32944-32956 , 文章类型: Article,,卷期:2008年283-47]
- Perturbations in neuregulin-1 (NRG1)/ErbB4 function have been associated with schizophrenia. Affected patients exhibit altered levels of these proteins and display hypofunction of glutamatergic synapses as well as altere...
- AtNOS/AtNOA1 Is a Functional Arabidopsis thaliana cGTPase and Not a Nitric-oxide Synthase
[作者:Moreau, M; Lee, GI; Wang, Y; Crane, BR; Klessig, DF,期刊:Journal of Biological Chemistry, 页码:32957-32967 , 文章类型: Article,,卷期:2008年283-47]
- AtNOS1 was previously identified as a potential nitric-oxide synthase (NOS) in Arabidopsis thaliana, despite lack of sequence similarity to animal NOSs. Although the dwarf and yellowish leaf phenotype of Atnos1 knock-out...
- The Structure of YqeH AN AtNOS1/AtNOA1 ORTHOLOG THAT COUPLES GTP HYDROLYSIS TO MOLECULAR RECOGNITION
[作者:Sudhamsu, J; Lee, GI; Klessig, DF; Crane, BR,期刊:Journal of Biological Chemistry, 页码:32968-32976 , 文章类型: Article,,卷期:2008年283-47]
- AtNOS1/AtNOA1 was identified as a nitric oxide-generating enzyme in plants, but that function has recently been questioned. To resolve issues surrounding AtNOA1 activity, we report the biochemical properties and a 2.36 a...
- Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal Response Elements
[作者:Pan, YF; Wansa, KDSA; Liu, MH; Zhao, B; Hong, SZ; Tan, PY; Lim, KS; Bourque, G; Liu, ET; Cheung, E,期刊:Journal of Biological Chemistry, 页码:32977-32988 , 文章类型: Article,,卷期:2008年283-47]
- Nuclear signaling by estrogens rapidly induces the global recruitment of estrogen receptors (ERs) to thousands of highly specific locations in the genome. Here, we have examined whether ER binding sites that are located ...
- Selective Structural Change by Spermidine in the Bulged-out Region of Double-stranded RNA and Its Effect on RNA Function
[作者:Higashi, K; Terui, Y; Suganami, A; Tamura, Y; Nishimura, K; Kashiwagi, K; Igarashi, K,期刊:Journal of Biological Chemistry, 页码:32989-32994 , 文章类型: Article,,卷期:2008年283-47]
- Polyamines play important roles in cell growth mainly through their interaction with RNA. We have previously reported that polyamines stimulate the synthesis of oligopeptide-binding protein OppA in Escherichia coli and t...
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