- Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways
[作者:Horiuchi, D; Huskey, NE; Kusdra, L; Wohlbold, L; Merrick, KA; Zhang, C; Creasman, KJ; Shokat, KM; Fisher, RP; Goga, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1019-E1027 , 文章类型: Article,,卷期:2012年109-17]
- A family of conserved serine/threonine kinases known as cyclin-dependent kinases (CDKs) drives orderly cell cycle progression in mammalian cells. Prior studies have suggested that CDK2 regulates S-phase entry and progres...
- Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines
[作者:Hepworth, MR; Danilowicz-Luebert, E; Rausch, S; Metz, M; Klotz, C; Maurer, M; Hartmann, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6644-6649 , 文章类型: Article,,卷期:2012年109-17]
- Mast cells (MCs) are potent inflammatory cells that are distributed throughout mucosal barrier tissues and respond rapidly to pathogenic stimuli. During helminth infections, MCs play an important role as late-stage effec...
- Staphylococcal biofilm-forming protein has a contiguous rod-like structure
[作者:Gruszka, DT; Wojdyla, JA; Bingham, RJ; Turkenburg, JP; Manfield, IW; Steward, A; Leech, AP; Geoghegan, JA; Foster, TJ; Clarke, J; Potts, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1011-E1018 , 文章类型: Article,,卷期:2012年109-17]
- Staphylococcus aureus and Staphylococcus epidermidis form communities (called biofilms) on inserted medical devices, leading to infections that affect many millions of patients worldwide and cause substantial morbidity a...
- Ecological and evolutionary determinants for the adaptive radiation of the Madagascan vangas
[作者:Jonsson, KA; Fabre, PH; Fritz, SA; Etienne, RS; Ricklefs, RE; Jorgensen, TB; Fjeldsa, J; Rahbek, C; Ericson, PGP; Woog, F; Pasquet, E; Irestedt, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6620-6625 , 文章类型: Article,,卷期:2012年109-17]
- Adaptive radiation is the rapid diversification of a single lineage into many species that inhabit a variety of environments or use a variety of resources and differ in traits required to exploit these. Why some lineages...
- Reassessment of the 2010-2011 Haiti cholera outbreak and rainfall-driven multiseason projections
[作者:Rinaldo, A; Bertuzzo, E; Mari, L; Righetto, L; Blokesch, M; Gatto, M; Casagrandi, R; Murray, M; Vesenbeckh, SM; Rodriguez-Iturbe, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6602-6607 , 文章类型: Article,,卷期:2012年109-17]
- Mathematical models can provide key insights into the course of an ongoing epidemic, potentially aiding real-time emergency management in allocating health care resources and by anticipating the impact of alternative int...
- Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk
[作者:Demichelis, F; Setlur, SR; Banerjee, S; Chakravarty, D; Chen, JYH; Chen, CX; Huang, JL; Beltran, H; Oldridge, DA; Kitabayashi, N; Stenzel, B; Schaefer, G; Horninger, W; Bektic, J; Chinnaiyan, AM; Goldenberg, S; Siddiqui, J; Regan, MM; Kearney, M; Soong, TD; Rickman, DS; Elemento, O; Wei, JT; Scherr, DS; Sanda, MA; Bartsch, G; Lee, C; Klocker, H; Rubin, MA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6686-6691 , 文章类型: Article,,卷期:2012年109-17]
- Copy number variants (CNVs) are a recently recognized class of human germ line polymorphisms and are associated with a variety of human diseases, including cancer. Because of the strong genetic influence on prostate canc...
- Molecular MRI enables early and sensitive detection of brain metastases
[作者:Serres, S; Soto, MS; Hamilton, A; McAteer, MA; Carbonell, WS; Robson, MD; Ansorge, O; Khrapitchev, A; Bristow, C; Balathasan, L; Weissensteiner, T; Anthony, DC; Choudhury, RP; Muschel, RJ; Sibson, NR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6674-6679 , 文章类型: Article,,卷期:2012年109-17]
- Metastasis to the brain is a leading cause of cancer mortality. The current diagnostic method of gadolinium-enhanced MRI is sensitive only to larger tumors, when therapeutic options are limited. Earlier detection of brai...
- Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions
[作者:Kashio, M; Sokabe, T; Shintaku, K; Uematsu, T; Fukuta, N; Kobayashi, N; Mori, Y; Tominaga, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6745-6750 , 文章类型: Article,,卷期:2012年109-17]
- The ability to sense temperature is essential for organism survival and efficient metabolism. Body temperatures profoundly affect many physiological functions, including immunity. Transient receptor potential melastatin ...
- Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy
[作者:Rahmeh, R; Damian, M; Cottet, M; Orcel, H; Mendre, C; Durroux, T; Sharma, KS; Durand, G; Pucci, B; Trinquet, E; Zwier, JM; Deupi, X; Bron, P; Baneres, JL; Mouillac, B; Granier, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6733-6738 , 文章类型: Article,,卷期:2012年109-17]
- G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that mediate most cellular responses to hormones and neurotransmitters, representing the largest group of therapeutic targets. Recent studies show that...
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