- Mind bomb 1 is required for pancreatic beta-cell formation
[作者:Horn, S; Kobberup, S; Jorgensen, MC; Kalisz, M; Klein, T; Kageyama, R; Gegg, M; Lickert, H; Lindner, J; Magnuson, MA; Kong, YY; Serup, P; Ahnfelt-Ronne, J; Jensen, JN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7356-7361 , 文章类型: Article,,卷期:2012年109-19]
- During early pancreatic development, Notch signaling represses differentiation of endocrine cells and promotes proliferation of Nkx6-1(+)Ptf1a(+) multipotent progenitor cells (MPCs). Later, antagonistic interactions betw...
- Cenozoic imprints on the phylogenetic structure of palm species assemblages worldwide
[作者:Kissling, WD; Eiserhardt, WL; Baker, WJ; Borchsenius, F; Couvreur, TLP; Balslev, H; Svenning, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7379-7384 , 文章类型: Article,,卷期:2012年109-19]
- Despite long-standing interest in the origin and maintenance of species diversity, little is known about historical drivers of species assemblage structure at large spatiotemporal scales. Here, we use global species dist...
- Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity
[作者:Hoch, E; Lin, W; Chai, J; Hershfinkel, M; Fu, D; Sekler, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7202-7207 , 文章类型: Article,,卷期:2012年109-19]
- Zinc and cadmium are similar metal ions, but though Zn2+ is an essential nutrient, Cd2+ is a toxic and common pollutant linked to multiple disorders. Faster body turnover and ubiquitous distribution of Zn2+ vs. Cd2+ sugg...
- Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling
[作者:Middleton, AM; Ubeda-Tomas, S; Griffiths, J; Holman, T; Hedden, P; Thomas, SG; Phillips, AL; Holdsworth, MJ; Bennett, MJ; King, JR; Owen, MR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7571-7576 , 文章类型: Article,,卷期:2012年109-19]
- The hormone gibberellin (GA) is a key regulator of plant growth. Many of the components of the gibberellin signal transduction [ e. g., GIBBERELLIN INSENSITIVE DWARF 1 (GID1) and DELLA], biosynthesis [e.g., GA 20-oxidase...
- Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans
[作者:Ji, FY; Sharpley, MS; Derbeneva, O; Alves, LS; Qian, P; Wang, YL; Chalkia, D; Lvova, M; Xu, JC; Yao, W; Simon, M; Platt, J; Xu, SQ; Angelin, A; Davila, A; Huang, TS; Wang, PH; Chuang, LM; Moore, LG; Qian, GS; Wallace, DC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7391-7396 , 文章类型: Article,,卷期:2012年109-19]
- The distinction between mild pathogenic mtDNA mutations and population polymorphisms can be ambiguous because both are homoplasmic, alter conserved functions, and correlate with disease. One possible explanation for this...
- Type II membrane protein CD69 regulates the formation of resting T-helper memory
[作者:Shinoda, K; Tokoyoda, K; Hanazawa, A; Hayashizaki, K; Zehentmeier, S; Hosokawa, H; Iwamura, C; Koseki, H; Tumes, DJ; Radbruch, A; Nakayama, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7409-7414 , 文章类型: Article,,卷期:2012年109-19]
- Memory T-helper (Th) lymphocytes are crucial for the maintenance of acquired immunity to eliminate infectious pathogens. We have previously demonstrated that most memory Th lymphocytes reside and rest on stromal niches o...
- Human fibrocytes coexpress thyroglobulin and thyrotropin receptor
[作者:Fernando, R; Atkins, S; Raychaudhuri, N; Lu, Y; Li, B; Douglas, RS; Smith, TJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7427-7432 , 文章类型: Article,,卷期:2012年109-19]
- Thyroglobulin (Tg) is the macromolecular precursor of thyroid hormones and is thought to be uniquely expressed by thyroid epithelial cells. Tg and the thyroid-stimulating hormone receptor (TSHR) are targets for autoantib...
- Structural basis of human DNA polymerase eta-mediated chemoresistance to cisplatin
[作者:Zhao, Y; Biertumpfel, C; Gregory, MT; Hua, YJ; Hanaoka, F; Yang, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7269-7274 , 文章类型: Article,,卷期:2012年109-19]
- Cisplatin (cis-diamminedichloroplatinum) and related compounds cause DNA damage and are widely used as anticancer agents. Chemoresistance to cisplatin treatment is due in part to translesion synthesis by human DNA polyme...
- Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
[作者:Ohto, U; Fukase, K; Miyake, K; Shimizu, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7421-7426 , 文章类型: Article,,卷期:2012年109-19]
- Lipopolysaccharide (LPS), also known as endotoxin, activates the innate immune response through toll-like receptor 4 (TLR4) and its coreceptor, MD-2. MD-2 has a unique hydrophobic cavity that directly binds to lipid A, t...
- Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions
[作者:de Alwis, R; Smith, SA; Olivarez, NP; Messer, WB; Huynh, JP; Wahala, WMPB; White, LJ; Diamond, MS; Baric, RS; Crowe, JE; de Silva, AM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7439-7444 , 文章类型: Article,,卷期:2012年109-19]
- Dengue is a mosquito-borne flavivirus that is spreading at an unprecedented rate and has developed into a major health and economic burden in over 50 countries. Even though infected individuals develop potent and long-la...
- Monitoring single-cell bioenergetics via the coarsening of emulsion droplets
[作者:Boitard, L; Cottinet, D; Kleinschmitt, C; Bremond, N; Baudry, J; Yvert, G; Bibette, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7181-7186 , 文章类型: Article,,卷期:2012年109-19]
- Microorganisms are widely used to generate valuable products, and their efficiency is a major industrial focus. Bioreactors are typically composed of billions of cells, and available measurements only reflect the overall...
- Committed carbon emissions, deforestation, and community land conversion from oil palm plantation expansion in West Kalimantan, Indonesia
[作者:Carlson, KM; Curran, LM; Ratnasari, D; Pittman, AM; Soares, BS; Asner, GP; Trigg, SN; Gaveau, DA; Lawrence, D; Rodrigues, HO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7559-7564 , 文章类型: Article,,卷期:2012年109-19]
- Industrial agricultural plantations are a rapidly increasing yet largely unmeasured source of tropical land cover change. Here, we evaluate impacts of oil palm plantation development on land cover, carbon flux, and agrar...
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