- Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
[作者:Cohen, S; Janicki-Deverts, D; Doyle, WJ; Miller, GE; Frank, E; Rabin, BS; Turner, RB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5995-5999 , 文章类型: Article,,卷期:2012年109-16]
- We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to down-regulate inflammatory response. Here we test the model in two viral-challenge studie...
- Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
[作者:Giang, E; Dorner, M; Prentoe, JC; Dreux, M; Evans, MJ; Bukh, J; Rice, CM; Ploss, A; Burton, DR; Law, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6205-6210 , 文章类型: Article,,卷期:2012年109-16]
- Hepatitis C virus (HCV) infects similar to 2% of the world's population. It is estimated that there are more than 500,000 new infections annually in Egypt, the country with the highest HCV prevalence. An effective vaccin...
- Molecular crowding creates traffic jams of kinesin motors on microtubules
[作者:Leduc, C; Padberg-Gehle, K; Varga, V; Helbing, D; Diez, S; Howard, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6100-6105 , 文章类型: Article,,卷期:2012年109-16]
- Despite the crowdedness of the interior of cells, microtubule-based motor proteins are able to deliver cargoes rapidly and reliably throughout the cytoplasm. We hypothesize that motor proteins may be adapted to operate i...
- Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase e in rolling circle DNA synthesis
[作者:Kang, YH; Galal, WC; Farina, A; Tappin, I; Hurwitz, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6042-6047 , 文章类型: Article,,卷期:2012年109-16]
- In eukaryotes, although the Mcm2-7 complex is a key component of the replicative DNA helicase, its association with Cdc45 and GINS (the CMG complex) is required for the activation of the DNA helicase. Here, we show that ...
- Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers
[作者:Putcha, BDK; Wright, E; Brunzelle, JS; Fernandez, EJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6084-6087 , 文章类型: Article,,卷期:2012年109-16]
- Thyroid hormones such as 3,3',5 triiodo-L-thyronine (T3) control numerous aspects of mammalian development and metabolism. The actions of such hormones are mediated by specific thyroid hormone receptors (TRs). TR belongs...
- Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation
[作者:Attems, J; Alpar, A; Spence, L; McParland, S; Heikenwalder, M; Uhlen, M; Tanila, H; Hokfelt, TGM; Harkany, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6259-6264 , 文章类型: Article,,卷期:2012年109-16]
- Expanding the repertoire of molecularly diverse neurons in the human nervous system is paramount to characterizing the neuronal networks that underpin sensory processing. Defining neuronal identities is particularly time...
- Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
[作者:Mitchell, SN; Stevenson, BJ; Muller, P; Wilding, CS; Egyir-Yawson, A; Field, SG; Hemingway, J; Paine, MJI; Ranson, H; Donnelly, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6147-6152 , 文章类型: Article,,卷期:2012年109-16]
- In the last decade there have been marked reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the prim...
- Morphine activates neuroinflammation in a manner parallel to endotoxin
[作者:Wang, XH; Loram, LC; Ramos, K; de Jesus, AJ; Thomas, J; Cheng, K; Reddy, A; Somogyi, AA; Hutchinson, MR; Watkins, LR; Yin, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6325-6330 , 文章类型: Article,,卷期:2012年109-16]
- Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid rec...
- Structural characterization of mRNA-tRNA translocation intermediates
[作者:Agirrezabala, X; Liao, HY; Schreiner, E; Fu, J; Ortiz-Meoz, RF; Schulten, K; Green, R; Frank, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6094-6099 , 文章类型: Article,,卷期:2012年109-16]
- Cryo-EM analysis of a wild-type Escherichia coli pretranslocational sample has revealed the presence of previously unseen intermediate substates of the bacterial ribosome during the first phase of translocation, characte...
- Structural diversity in social contagion
[作者:Ugander, J; Backstrom, L; Marlow, C; Kleinberg, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5962-5966 , 文章类型: Article,,卷期:2012年109-16]
- The concept of contagion has steadily expanded from its original grounding in epidemic disease to describe a vast array of processes that spread across networks, notably social phenomena such as fads, political opinions,...
- Viral-induced encephalitis initiates distinct and functional CD103(+) CD11b(+) brain dendritic cell populations within the olfactory bulb
[作者:D'Agostino, PM; Kwak, C; Vecchiarelli, HA; Toth, JG; Miller, JM; Masheeb, Z; McEwen, BS; Bulloch, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6175-6180 , 文章类型: Article,,卷期:2012年109-16]
- Dendritic cells (DC) are antigen-presenting cells found in both lymphoid and nonlymphoid organs, including the brain (bDC) of Cd11c/eyfp transgenic C57BL/6 mice. Using an intranasal vesicular stomatitis virus infection, ...
- 9,400 years of cosmic radiation and solar activity from ice cores and tree rings
[作者:Steinhilber, F; Abreu, JA; Beer, J; Brunner, I; Christl, M; Fischer, H; Heikkila, U; Kubik, PW; Mann, M; McCracken, KG; Miller, H; Miyahara, H; Oerter, H; Wilhelms, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5967-5971 , 文章类型: Article,,卷期:2012年109-16]
- Understanding the temporal variation of cosmic radiation and solar activity during the Holocene is essential for studies of the solar-terrestrial relationship. Cosmic-ray produced radionuclides, such as Be-10 and C-14 wh...
- In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis
[作者:Martinez-Corral, I; Olmeda, D; Dieguez-Hurtado, R; Tammela, T; Alitalo, K; Ortega, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6223-6228 , 文章类型: Article,,卷期:2012年109-16]
- Lymphatic vessel growth or lymphangiogenesis occurs during embryonic development and wound healing and plays an important role in tumor metastasis and inflammatory diseases. However, the possibility of noninvasive detect...
- Mouse model recapitulating human Fc gamma receptor structural and functional diversity
[作者:Smith, P; DiLillo, DJ; Bournazos, S; Li, FB; Ravetch, JV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6181-6186 , 文章类型: Article,,卷期:2012年109-16]
- The in vivo biological activities of IgG antibodies result from their bifunctional nature, in which antigen recognition by the Fab is coupled to the effector and immunomodulatory diversity found in the Fc domain. This di...
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