- Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction
[作者:Jiao, Y; Seeger, K; Lautrette, A; Gaubert, A; Mousson, F; Guerois, R; Mann, C; Ochsenbein, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2866-2871 , 文章类型: Article,,卷期:2012年109-8]
- The histone chaperone Asf1 and the checkpoint kinase Rad53 are found in a complex in budding yeast cells in the absence of genotoxic stress. Our data suggest that this complex involves at least three interaction sites. O...
- Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan
[作者:Floor, SN; Borja, MS; Gross, JD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2872-2877 , 文章类型: Article,,卷期:2012年109-8]
- Conformational dynamics in bilobed enzymes can be used to regulate their activity. One such enzyme, the eukaryotic decapping enzyme Dcp2, controls the half-life of mRNA by cleaving the 5' cap structure, which exposes a m...
- Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses
[作者:Lou, XL; Fan, F; Messa, M; Raimondi, A; Wu, YM; Looger, LL; Ferguson, SM; De Camilli, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E515-E523 , 文章类型: Article,,卷期:2012年109-8]
- Endocytic recycling of synaptic vesicles after exocytosis is critical for nervous system function. At synapses of cultured neurons that lack the two "neuronal" dynamins, dynamin 1 and 3, smaller excitatory postsynaptic c...
- Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development
[作者:Ma, PP; Pan, H; Montgomery, RL; Olson, EN; Schultz, RM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E481-E489 , 文章类型: Article,,卷期:2012年109-8]
- Dramatic changes in chromatin structure and histone modification occur during oocyte growth, as well as a global cessation of transcription. The role of histone modifications in these processes is poorly understood. We r...
- Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly
[作者:Yeo, GC; Baldock, C; Tuukkanen, A; Roessle, M; Dyksterhuis, LB; Wise, SG; Matthews, J; Mithieux, SM; Weiss, AS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2878-2883 , 文章类型: Article,,卷期:2012年109-8]
- The tropoelastin monomer undergoes stages of association by coacervation, deposition onto microfibrils, and cross-linking to form elastic fibers. Tropoelastin consists of an elastic N-terminal coil region and a cell-inte...
- Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis
[作者:Navaroli, DM; Bellve, KD; Standley, C; Lifshitz, LM; Cardia, J; Lambright, D; Leonard, D; Fogarty, KE; Corvera, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E471-E480 , 文章类型: Article,,卷期:2012年109-8]
- Cell surface receptors and other proteins internalize through diverse mechanisms at the plasma membrane and are sorted to different destinations. Different subpopulations of early endosomes have been described, raising t...
- Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus
[作者:Yasmin, S; Alcazar-Fuoli, L; Grundlinger, M; Puempel, T; Cairns, T; Blatzer, M; Lopez, JF; Grimalt, JO; Bignell, E; Haas, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E497-E504 , 文章类型: Article,,卷期:2012年109-8]
- Aspergillus fumigatus is the most common airborne fungal pathogen for humans. In this mold, iron starvation induces production of the siderophore triacetylfusarinine C (TAFC). Here we demonstrate a link between TAFC and ...
- Entropic origin of Mg2+-facilitated RNA folding
[作者:Fiore, JL; Holmstrom, ED; Nesbitt, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2902-2907 , 文章类型: Article,,卷期:2012年109-8]
- Mg2+ is essential for the proper folding and function of RNA, though the effect of Mg2+ concentration on the free energy, enthalpy, and entropy landscapes of RNA folding is unknown. This work exploits temperature-control...
- Actin filament curvature biases branching direction
[作者:Risca, VI; Wang, EB; Chaudhuri, O; Chia, JJ; Geissler, PL; Fletcher, DA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2913-2918 , 文章类型: Article,,卷期:2012年109-8]
- Mechanical cues affect many important biological processes in metazoan cells, such as migration, proliferation, and differentiation. Such cues are thought to be detected by specialized mechanosensing molecules linked to ...
- Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates
[作者:Botcherby, EJ; Smith, CW; Kohl, MM; Debarre, D; Booth, MJ; Juskaitis, R; Paulsen, O; Wilson, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2919-2924 , 文章类型: Article,,卷期:2012年109-8]
- Multiphoton microscopy is a powerful tool in neuroscience, promising to deliver important data on the spatiotemporal activity within individual neurons as well as in networks of neurons. A major limitation of current tec...
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