- Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory
[作者:Atsak, P; Hauer, D; Campolongo, P; Schelling, G; McGaugh, JL; Roozendaal, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3504-3509 , 文章类型: Article,,卷期:2012年109-9]
- There is extensive evidence that glucocorticoid hormones impair the retrieval of memory of emotionally arousing experiences. Although it is known that glucocorticoid effects on memory retrieval impairment depend on rapid...
- Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
[作者:Sehgal, N; Gupta, A; Valli, RK; Joshi, SD; Mills, JT; Hamel, E; Khanna, P; Jain, SC; Thakur, SS; Ravindranath, V,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3510-3515 , 文章类型: Article,,卷期:2012年109-9]
- A 30-d course of oral administration of a semipurified extract of the root of Withania somnifera consisting predominantly of withanolides and withanosides reversed behavioral deficits, plaque pathology, accumulation of b...
- Individual variability in functional connectivity predicts performance of a perceptual task
[作者:Baldassarre, A; Lewis, CM; Committeri, G; Snyder, AZ; Romani, GL; Corbetta, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3516-3521 , 文章类型: Article,,卷期:2012年109-9]
- People differ in their ability to perform novel perceptual tasks, both during initial exposure and in the rate of improvement with practice. It is also known that regions of the brain recruited by particular tasks change...
- Unified quantitative model of AMPA receptor trafficking at synapses
[作者:Czondor, K; Mondin, M; Garcia, M; Heine, M; Frischknecht, R; Choquet, D; Sibarita, JB; Thoumine, OR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3522-3527 , 文章类型: Article,,卷期:2012年109-9]
- Trafficking of AMPA receptors (AMPARs) plays a key role in synaptic transmission. However, a general framework integrating the two major mechanisms regulating AMPAR delivery at post-synapses (i.e., surface diffusion and ...
- Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice
[作者:Di Pardo, A; Maglione, V; Alpaugh, M; Horkey, M; Atwal, RS; Sassone, J; Ciammola, A; Steffan, JS; Fouad, K; Truant, R; Sipione, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3528-3533 , 文章类型: Article,,卷期:2012年109-9]
- Huntington disease (HD) is a progressive neurodegenerative monogenic disorder caused by expansion of a polyglutamine stretch in the huntingtin (Htt) protein. Mutant huntingtin triggers neural dysfunction and death, mainl...
- Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors
[作者:den Boon, FS; Chameau, P; Schaafsma-Zhao, Q; van Aken, W; Bari, M; Oddi, S; Kruse, CG; Maccarrone, M; Wadman, WJ; Werkman, TR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3534-3539 , 文章类型: Article,,卷期:2012年109-9]
- The endocannabinoid (eCB) system is widely expressed throughout the central nervous system (CNS) and the functionality of type-1 cannabinoid receptors in neurons is well documented. In contrast, there is little knowledge...
- N-acetyl serotonin derivatives as potent neuroprotectants for retinas
[作者:Shen, JY; Ghai, K; Sompol, P; Liu, X; Cao, XB; Iuvone, PM; Ye, KQ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3540-3545 , 文章类型: Article,,卷期:2012年109-9]
- N-acetylserotonin (NAS) is synthesized from serotonin by arylalkylamine N-acetyltransferase (AANAT), which is predominantly expressed in the pineal gland and retina. NAS activates TrkB in a circadian manner and exhibits ...
- Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons
[作者:Baranek, C; Dittrich, M; Parthasarathy, S; Bonnon, CG; Britanova, O; Lanshakov, D; Boukhtouche, F; Sommer, JE; Colmenares, C; Tarabykin, V; Atanasoski, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3546-3551 , 文章类型: Article,,卷期:2012年109-9]
- First insights into the molecular programs orchestrating the progression from neural stem cells to cortical projection neurons are emerging. Loss of the transcriptional regulator Ski has been linked to the human 1p36 del...
- Molecular mechanism of pharmacological activation of BK channels
[作者:Gessner, G; Cui, YM; Otani, Y; Ohwada, T; Soom, M; Hoshi, T; Heinemann, SH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3552-3557 , 文章类型: Article,,卷期:2012年109-9]
- Large-conductance voltage- and Ca2+-activated K+ (Slo1 BK) channels serve numerous cellular functions, and their dysregulation is implicated in various diseases. Drugs activating BK channels therefore bear substantial th...
- Discovery of a cytosolic/soluble ferroxidase in rodent enterocytes
[作者:Ranganathan, PN; Lu, Y; Fuqua, BK; Collins, JF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3564-3569 , 文章类型: Article,,卷期:2012年109-9]
- Hephaestin (Heph), a membrane-bound multicopper ferroxidase (FOX) expressed in duodenal enterocytes, is required for optimal iron absorption. However, sex-linked anemia (sla) mice harboring a 194-amino acid deletion in t...
- Trans Chromosomal Methylation in Arabidopsis hybrids
[作者:Greaves, IK; Groszmann, M; Ying, H; Taylor, JM; Peacock, WJ; Dennis, ES,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3570-3575 , 文章类型: Article,,卷期:2012年109-9]
- The heterotic hybrid offspring of Arabidopsis accessions C24 and Landsberg erecta have altered methylomes. Changes occur most frequently at loci where parental methylation levels are different. There are context-specific...
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