- Surface multiheme c-type cytochromes from Thermincola potens and implications for respiratory metal reduction by Gram- positive bacteria
[作者:Carlson, HK; Iavarone, AT; Gorur, A; Yeo, BS; Tran, R; Melnyk, RA; Mathies, RA; Auer, M; Coates, JD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1702-1707 , 文章类型: Article,,卷期:2012年109-5]
- Almost nothing is known about the mechanisms of dissimilatory metal reduction byGram-positive bacteria, although theymay be the dominant species in some environments. Thermincola potens strain JR was isolated from the an...
- Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor beta ligand
[作者:Tan, XJ; Dai, YB; Wu, WF; Kim, HJ; Barros, RPA; Richardson, TI; Yaden, BC; Warner, M; McKinzie, DL; Krishnan, V; Gustafssona, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1708-1712 , 文章类型: Article,,卷期:2012年109-5]
- An estrogen receptor (ER) beta ligand (LY3201) with a preference for ER beta over ER alpha was administered in s.c. pellets releasing 0.04 mg/d. The brains of these mice were examined 3 d after treatment had begun. Altho...
- Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
[作者:Lasker, K; Forster, F; Bohn, S; Walzthoeni, T; Villa, E; Unverdorben, P; Beck, F; Aebersold, R; Sali, A; Baumeister, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1380-1387 , 文章类型: Article,,卷期:2012年109-5]
- The 26S proteasome is at the executive end of the ubiquitin-proteasome pathway for the controlled degradation of intracellular proteins. While the structure of its 20S core particle (CP) has been determined by X-ray crys...
- Functional profiling of neurons through cellular neuropharmacology
[作者:Teichert, RW; Smith, NJ; Raghuraman, S; Yoshikami, D; Light, AR; Olivera, BM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1388-1395 , 文章类型: Article,,卷期:2012年109-5]
- We describe a functional profiling strategy to identify and characterize subtypes of neurons present in a peripheral ganglion, which should be extendable to neurons in the CNS. In this study, dissociated dorsal-root gang...
- Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPK alpha) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches
[作者:Noda, Y; Niwa, S; Homma, N; Fukuda, H; Imajo-Ohmi, S; Hirokawa, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1725-1730 , 文章类型: Article,,卷期:2012年109-5]
- Neuronal morphology is regulated by cytoskeletons. Kinesin superfamily protein 2A (KIF2A) depolymerizes microtubules (MTs) at growth cones and regulates axon pathfinding. The factors controlling KIF2A in neurite developm...
- Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep
[作者:Peyrache, A; Dehghani, N; Eskandar, EN; Madsen, JR; Anderson, WS; Donoghue, JA; Hochberg, LR; Halgren, E; Cash, SS; Destexhe, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1731-1736 , 文章类型: Article,,卷期:2012年109-5]
- Intracranial recording is an important diagnostic method routinely used in a number of neurological monitoring scenarios. In recent years, advancements in such recordings have been extended to include unit activity of an...
- A beta neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors
[作者:You, HT; Tsutsui, S; Hameed, S; Kannanayakal, TJ; Chen, LN; Xia, P; Engbers, JDT; Lipton, SA; Stys, PK; Zamponi, GW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1737-1742 , 文章类型: Article,,卷期:2012年109-5]
- N-methyl-D-aspartate receptors (NMDARs) mediate critical CNS functions, whereas excessive activity contributes to neuronal damage. At physiological glycine concentrations, NMDAR currents recorded from cultured rodent hip...
- Evidence for the extraterrestrial origin of a natural quasicrystal
[作者:Bindi, L; Eiler, JM; Guan, YB; Hollister, LS; MacPherson, G; Steinhardt, PJ; Yao, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1396-1401 , 文章类型: Article,,卷期:2012年109-5]
- We present evidence that a rock sample found in the Koryak Mountains in Russia and containing icosahedrite, an icosahedral quasicrystalline phase with composition Al63Cu24Fe13, is part of a meteorite, likely formed in th...
- Unidirectionally aligned line patterns driven by entropic effects on faceted surfaces
[作者:Hong, SW; Huh, J; Gu, XD; Lee, DH; Jo, WH; Park, S; Xu, T; Russell, TP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1402-1406 , 文章类型: Article,,卷期:2012年109-5]
- A simple, versatile approach to the directed self-assembly of block copolymers into a macroscopic array of unidirectionally aligned cylindrical microdomains on reconstructed faceted single crystal surfaces or on flexible...
- Coaxial multishell nanowires with high-quality electronic interfaces and tunable optical cavities for ultrathin photovoltaics
[作者:Kempa, TJ; Cahoon, JF; Kim, SK; Day, RW; Bell, DC; Park, HG; Lieber, CM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1407-1412 , 文章类型: Article,,卷期:2012年109-5]
- Silicon nanowires (NWs) could enable low-cost and efficient photovoltaics, though their performance has been limited by nonideal electrical characteristics and an inability to tune absorption properties. We overcome thes...
- Telomere length in early life predicts lifespan
[作者:Heidinger, BJ; Blount, JD; Boner, W; Griffiths, K; Metcalfe, NB; Monaghan, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1743-1748 , 文章类型: Article,,卷期:2012年109-5]
- The attrition of telomeres, the ends of eukaryote chromosomes, is thought to play an important role in cell deterioration with advancing age. The observed variation in telomere length among individuals of the same age is...
- Ca2+ signaling amplification by oligomerization of L-type Ca(v)1.2 channels
[作者:Dixon, RE; Yuan, C; Cheng, EP; Navedo, MF; Santana, LF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1749-1754 , 文章类型: Article,,卷期:2012年109-5]
- Ca2+ influx via L-type Ca(v)1.2 channels is essential for multiple physiological processes, including gene expression, excitability, and contraction. Amplification of the Ca2+ signals produced by the opening of these cha...
- Preceramic maize from Paredones and Huaca Prieta, Peru
[作者:Grobman, A; Bonavia, D; Dillehay, TD; Piperno, DR; Iriarte, J; Holst, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1755-1759 , 文章类型: Article,,卷期:2012年109-5]
- Maize (Zea mays ssp. mays) is among the world's most important and ancient domesticated crops. Although the chronology of its domestication and initial dispersals out of Mexico into Central and South America has become m...
- Constant-speed vibrational signaling along polyethyleneglycol chain up to 60-angstrom distance
[作者:Lin, ZW; Rubtsov, IV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1413-1418 , 文章类型: Article,,卷期:2012年109-5]
- A series of azido-PEG-succinimide ester oligomers with a number of repeating PEG units of 0, 4, 8, and 12 (azPEG0, 4, 8, and 12) was investigated using a relaxation-assisted two-dimensional infrared (RA 2DIR) spectroscop...
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