- Education of a model student
[作者:Novikoff, TP; Kleinberg, JM; Strogatz, SH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1868-1873 , 文章类型: Article,,卷期:2012年109-6]
- A dilemma faced by teachers, and increasingly by designers of educational software, is the trade-off between teaching new material and reviewing what has already been taught. Complicating matters, review is useful only i...
- Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/beta-catenin signaling
[作者:Egea, V; Zahler, S; Rieth, N; Neth, P; Popp, T; Kehe, K; Jochum, M; Ries, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E309-E316 , 文章类型: Article,,卷期:2012年109-6]
- Tissue inhibitor of metalloproteinases 1 (TIMP-1) is a matrix metalloproteinase (MMP)-independent regulator of growth and apoptosis in various cell types. The receptors and signaling pathways that are involved in the gro...
- Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase
[作者:Fafarman, AT; Sigala, PA; Schwans, JP; Fenn, TD; Herschlag, D; Boxer, SG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E299-E308 , 文章类型: Article,,卷期:2012年109-6]
- Understanding the electrostatic forces and features within highly heterogeneous, anisotropic, and chemically complex enzyme active sites and their connection to biological catalysis remains a long-standing challenge, in ...
- Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms
[作者:Han, S; Yu, FH; Schwartz, MD; Linton, JD; Bosma, MM; Hurley, JB; Catterall, WA; de la Iglesiaa, HO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E368-E377 , 文章类型: Article,,卷期:2012年109-6]
- Na(v)1.1 is the primary voltage-gated Na+ channel in several classes of GABAergic interneurons, and its reduced activity leads to reduced excitability and decreased GABAergic tone. Here, we show that Na(v)1.1 channels ar...
- Uranyl peroxide enhanced nuclear fuel corrosion in seawater
[作者:Armstrong, CR; Nyman, M; Shvareva, T; Sigmon, GE; Burns, PC; Navrotsky, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1874-1877 , 文章类型: Article,,卷期:2012年109-6]
- The Fukushima-Daiichi nuclear accident brought together compromised irradiated fuel and large amounts of seawater in a high radiation field. Based on newly acquired thermochemical data for a series of uranyl peroxide com...
- Evidence for social working memory from a parametric functional MRI study
[作者:Meyer, ML; Spunt, RP; Berkman, ET; Taylor, SE; Lieberman, MD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1883-1888 , 文章类型: Article,,卷期:2012年109-6]
- Keeping track of various amounts of social cognitive information, including people's mental states, traits, and relationships, is fundamental to navigating social interactions. However, to date, no research has examined ...
- Use of red ochre by early Neandertals
[作者:Roebroeks, W; Sier, MJ; Nielsen, TK; De Loecker, D; Pares, JM; Arps, CES; Mucher, HJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1889-1894 , 文章类型: Article,,卷期:2012年109-6]
- The use of manganese and iron oxides by late Neandertals is well documented in Europe, especially for the period 60-40 kya. Such finds often have been interpreted as pigments even though their exact function is largely u...
- Interplay between mismatch repair and chromatin assembly
[作者:Schopf, B; Bregenhorn, S; Quivy, JP; Kadyrov, FA; Almouzni, G; Jiricny, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1895-1900 , 文章类型: Article,,卷期:2012年109-6]
- Single strand nicks and gaps in DNA have been reported to increase the efficiency of nucleosome loading mediated by chromatin assembly factor 1 (CAF-1). However, on mismatch-containing substrates, these strand discontinu...
- Comparative metatranscriptomics identifies molecular bases for the physiological responses of phytoplankton to varying iron availability
[作者:Marchetti, A; Schruth, DM; Durkin, CA; Parker, MS; Kodner, RB; Berthiaume, CT; Morales, R; Allen, AE; Armbrust, EV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E317-E325 , 文章类型: Article,,卷期:2012年109-6]
- In vast expanses of the oceans, growth of large phytoplankton such as diatoms is limited by iron availability. Diatoms respond almost immediately to the delivery of iron and rapidly compose the majority of phytoplankton ...
- CD4 and CD8 T cells require different membrane gangliosides for activation
[作者:Nagafuku, M; Okuyama, K; Onimaru, Y; Suzuki, A; Odagiri, Y; Yamashita, T; Iwasaki, K; Fujiwara, M; Takayanagi, M; Ohno, I; Inokuchi, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E336-E342 , 文章类型: Article,,卷期:2012年109-6]
- Initial events of T-cell activation involve movement of the T-cell receptor into lipid rafts. Gangliosides are major components of lipid rafts. While investigating T-cell activation in ganglioside-deficient mice, we obse...
- Host RNAs, including transposons, are encapsidated by a eukaryotic single-stranded RNA virus
[作者:Routh, A; Domitrovic, T; Johnson, JE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1907-1912 , 文章类型: Article,,卷期:2012年109-6]
- Next-generation sequencing is a valuable tool in our growing understanding of the genetic diversity of viral populations. Using this technology, we have investigated the RNA content of a purified nonenveloped single-stra...
- Global kinetic analysis of proteolysis via quantitative targeted proteomics
[作者:Agard, NJ; Mahrus, S; Trinidad, JC; Lynn, A; Burlingame, AL; Wells, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1913-1918 , 文章类型: Article,,卷期:2012年109-6]
- Mass spectrometry-based proteomics is a powerful tool for identifying hundreds to thousands of posttranslational modifications in complex mixtures. However, it remains enormously challenging to simultaneously assess the ...
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