- Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
[作者:Kato, L; Begum, NA; Burroughs, AM; Doi, T; Kawai, J; Daub, CO; Kawaguchi, T; Matsuda, F; Hayashizaki, Y; Honjo, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2479-2484 , 文章类型: Article,,卷期:2012年109-7]
- Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or c...
- Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection
[作者:Onodera, T; Takahashi, Y; Yokoi, Y; Ato, M; Kodama, Y; Hachimura, S; Kurosaki, T; Kobayashi, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2485-2490 , 文章类型: Article,,卷期:2012年109-7]
- After pulmonary virus infection, virus-binding B cells ectopically accumulate in the lung. However, their contribution to protective immunity against reinfecting viruses remains unknown. Here, we show the phenotypes and ...
- Origins of tumor-associated macrophages and neutrophils
[作者:Cortez-Retamozo, V; Etzrodt, M; Newton, A; Rauch, PJ; Chudnovskiy, A; Berger, C; Ryan, RJH; Iwamoto, Y; Marinelli, B; Gorbatov, R; Forghani, R; Novobrantseva, TI; Koteliansky, V; Figueiredo, JL; Chen, JW; Anderson, DG; Nahrendorf, M; Swirski, FK; Weissleder, R; Pittet, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2491-2496 , 文章类型: Article,,卷期:2012年109-7]
- Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) can control cancer growth and exist in almost all solid neoplasms. The cells are known to descend from immature monocytic and granulocytic cells...
- Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
[作者:Pilotte, L; Larrieu, P; Stroobant, V; Colau, D; Dolusic, E; Frederick, R; De Plaen, E; Uyttenhove, C; Wouters, J; Masereel, B; Van den Eynde, BJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2497-2502 , 文章类型: Article,,卷期:2012年109-7]
- Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO1) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance, and IDO1 inhibition is an active area of drug devel...
- Structural reorganization of the interleukin-7 signaling complex
[作者:McElroy, CA; Holland, PJ; Zhao, P; Lim, JM; Wells, L; Eisenstein, E; Walsh, STR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2503-2508 , 文章类型: Article,,卷期:2012年109-7]
- We report here an unliganded receptor structure in the common gamma-chain (gamma(c)) family of receptors and cytokines. The crystal structure of the unliganded form of the interleukin-7 alpha receptor (IL-7R alpha) extra...
- Indirect evidence that maternal microchimerism in cord blood mediates a graft-versus-leukemia effect in cord blood transplantation
[作者:van Rood, JJ; Scaradavou, A; Stevens, CE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2509-2514 , 文章类型: Article,,卷期:2012年109-7]
- During pregnancy women can develop B- and T-cell immunity against the inherited paternal antigens (IPAs) of the fetus, such as HLA, peptides of minor histocompatibilty antigens, and possibly oncofetal antigens. The biolo...
- Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
[作者:Nanduri, J; Makarenko, V; Reddy, VD; Yuan, GX; Pawar, A; Wang, N; Khan, SA; Zhang, X; Kinsman, B; Peng, YJ; Kumar, GK; Fox, AP; Godley, LA; Semenza, GL; Prabhakar, NR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2515-2520 , 文章类型: Article,,卷期:2012年109-7]
- Recurrent apnea with intermittent hypoxia is a major clinical problem in preterm infants. Recent studies, although limited, showed that adults who were born preterm exhibit increased incidence of sleep-disordered breathi...
- Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells
[作者:Fang, HT; Zhang, B; Pan, XF; Gao, L; Zhen, T; Zhao, HX; Ma, L; Xie, J; Liu, Z; Yu, XJ; Cheng, X; Feng, TT; Zhang, FX; Yang, Y; Hu, ZG; Sheng, GQ; Chen, YL; Chen, SJ; Chen, Z; Zhou, GB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2521-2526 , 文章类型: Article,,卷期:2012年109-7]
- The boronic acid dipeptide bortezomib inhibits the chymotrypsin-like activity of the 26S proteasome and shows significant therapeutic efficacy in multiple myeloma. However, recent studies suggest that bortezomib may have...
- Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
[作者:Lujan, E; Chanda, S; Ahlenius, H; Sudhof, TC; Wernig, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2527-2532 , 文章类型: Article,,卷期:2012年109-7]
- We recently showed that defined sets of transcription factors are sufficient to convert mouse and human fibroblasts directly into cells resembling functional neurons, referred to as "induced neuronal" (iN) cells. For som...
- Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5
[作者:Scholl, UI; Nelson-Williams, C; Yue, P; Grekin, R; Wyatt, RJ; Dillon, MJ; Couch, R; Hammer, LK; Harley, FL; Farhi, A; Wang, WH; Lifton, RP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2533-2538 , 文章类型: Article,,卷期:2012年109-7]
- We recently implicated two recurrent somatic mutations in an adrenal potassium channel, KCNJ5, as a cause of aldosterone-producing adrenal adenomas (APAs) and one inherited KCNJ5 mutation in a Mendelian form of early sev...
- Inhibiting platelet-stimulated blood coagulation by inhibition of mitochondrial respiration
[作者:Barile, CJ; Herrmann, PC; Tyvoll, DA; Collman, JP; Decreau, RA; Bull, BS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2539-2543 , 文章类型: Article,,卷期:2012年109-7]
- Platelets are important mediators of blood coagulation that lack nuclei, but contain mitochondria. Although the presence of mitochondria in platelets has long been recognized, platelet mitochondrial function remains larg...
- Modeling hepatitis C virus infection using human induced pluripotent stem cells
[作者:Schwartz, RE; Trehan, K; Andrus, L; Sheahan, TP; Ploss, A; Duncan, SA; Rice, CM; Bhatia, SN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2544-2548 , 文章类型: Article,,卷期:2012年109-7]
- Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability t...
- Glut1-mediated glucose transport regulates HIV infection
[作者:Loisel-Meyer, S; Swainson, L; Craveiro, M; Oburoglu, L; Mongellaz, C; Costa, C; Martinez, M; Cosset, FL; Battini, JL; Herzenberg, LA; Herzenberg, LA; Atkuri, KR; Sitbon, M; Kinet, S; Verhoeyen, E; Taylor, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2549-2554 , 文章类型: Article,,卷期:2012年109-7]
- Cell cycle entry is commonly considered to positively regulate HIV-1 infection of CD4 T cells, raising the question as to how quiescent lymphocytes, representing a large portion of the viral reservoir, are infected in vi...
- Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)
[作者:Palamarchuk, A; Yan, PS; Zanesi, N; Wang, LN; Rodrigues, B; Murphy, M; Balatti, V; Bottoni, A; Nazaryan, N; Alder, H; Rassenti, L; Kipps, TJ; Freitas, M; Croce, CM; Pekarsky, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2555-2560 , 文章类型: Article,,卷期:2012年109-7]
- B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia. Deregulation of the T-cell leukemia/lymphoma 1 oncogene (TCL1) in mouse B cells causes a CD5(+) leukemia similar to aggressive human CLL. To ex...
- Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development
[作者:Tsuji-Takechi, K; Negishi-Koga, T; Sumiya, E; Kukita, A; Kato, S; Maeda, T; Pandolfi, PP; Moriyama, K; Takayanagi, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2561-2566 , 文章类型: Article,,卷期:2012年109-7]
- Cell fate determination is tightly regulated by transcriptional activators and repressors. Leukemia/lymphoma-related factor (LRF; encoded by Zbtb7a), known as a POK (POZ/BTB and Kruppel) family transcriptional repressor,...
- Decreased osteoclastogenesis in serotonin-deficient mice
[作者:Chabbi-Achengli, Y; Coudert, AE; Callebert, J; Geoffroy, V; Cote, F; Collet, C; de Vernejoul, MC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2567-2572 , 文章类型: Article,,卷期:2012年109-7]
- Peripheral serotonin, synthesized by tryptophan hydroxylase-1 (TPH1), has been shown to play a key role in several physiological functions. Recently, controversy has emerged about whether peripheral serotonin has any eff...
|