- Mitaplatin Increases Sensitivity of Tumor Cells to Cisplatin by Inducing Mitochondrial Dysfunction
[作者:Xue, X; You, S; Zhang, Q; Wu, Y; Zou, GZ; Wang, PC; Zhao, YL; Xu, Y; Jia, L; Zhang, XN; Liang, XJ,期刊:Molecular Pharmaceutics, 页码:634-644 , 文章类型: Article,,卷期:2012年9-3]
- Tumor resistance to chemotherapy is the major obstacle to employ cisplatin, one of the broadly used chemotherapeutic drugs, for effective treatment of various tumors in the clinic. Most acknowledged mechanisms of cancer ...
- Positron Emission Tomography and Optical Imaging of Tumor CD105 Expression with a Dual-Labeled Monoclonal Antibody
[作者:Zhang, Y; Hong, H; Engle, JW; Yang, YN; Theuer, CP; Barnhart, TE; Cai, WB,期刊:Molecular Pharmaceutics, 页码:645-653 , 文章类型: Article,,卷期:2012年9-3]
- CD105 (endoglin) is an independent prognostic marker for poor prognosis in >10 solid tumor types, including breast cancer. The goal of this study was to develop a CD105-specific agent for both positron emission tomograph...
- Intravenous Delivery of Hydrophobin-Functionalized Porous Silicon Nanoparticles: Stability, Plasma Protein Adsorption and Biodistribution
[作者:Sarparanta, M; Bimbo, LM; Rytkonen, J; Makila, E; Laaksonen, TJ; Laaksonen, P; Nyman, M; Salonen, J; Linder, MB; Hirvonen, J; Santos, HA; Airaksinen, AJ,期刊:Molecular Pharmaceutics, 页码:654-663 , 文章类型: Article,,卷期:2012年9-3]
- Rapid immune recognition and subsequent elimination from the circulation hampers the use of many nanomaterials as carriers to targeted drug delivery and controlled release in the intravenous route. Here, we report the ef...
- Balancing the Pharmacokinetics and Pharmacodynamics of Interferon-alpha 2b and Human Serum Albumin Fusion Protein by Proteolytic or Reductive Cleavage Increases Its in Vivo Therapeutic Efficacy
[作者:Zhao, HL; Xue, C; Du, JL; Ren, M; Xia, S; Liu, ZM,期刊:Molecular Pharmaceutics, 页码:664-670 , 文章类型: Article,,卷期:2012年9-3]
- Human serum albumin (HSA) fusion (Albufusion) technology has evolved to be a general strategy to increase the in vivo half-lives of therapeutic proteins. However, because of the steric hindrance effect of HSA, convention...
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