- Dual Specificity of Anti-CXCL10-CXCL9 Antibodies Is Governed by Structural Mimicry
[作者:Fagete, S; Rousseau, F; Magistrelli, G; Gueneau, F; Ravn, U; Kosco-Vilbois, MH; Fischer, N,期刊:Journal of Biological Chemistry, 页码:1458-1467 , 文章类型: Article,,卷期:2012年287-2]
- Dual-specific antibodies are characterized by an antigen-combining site mediating specific interactions with two different antigens. We have generated five dual-specific single chain variable fragments (scFv) that neutra...
- An Electrostatic Switch Controls Palmitoylation of the Large Conductance Voltage- and Calcium-activated Potassium (BK) Channel
[作者:Jeffries, O; Tian, LJ; McClafferty, H; Shipston, MJ,期刊:Journal of Biological Chemistry, 页码:1468-1477 , 文章类型: Article,,卷期:2012年287-2]
- Protein palmitoylation is a major dynamic posttranslational regulator of protein function. However, mechanisms that control palmitoylation are poorly understood. In many proteins, palmitoylation occurs at cysteine residu...
- beta-Glucan from Lentinus edodes Inhibits Nitric Oxide and Tumor Necrosis Factor-alpha Production and Phosphorylation of Mitogen-activated Protein Kinases in Lipopolysaccharide-stimulated Murine RAW 264.7 Macrophages
[作者:Xu, XJ; Yasuda, M; Nakamura-Tsuruta, S; Mizuno, M; Ashida, H,期刊:Journal of Biological Chemistry, 页码:871-878 , 文章类型: Article,,卷期:2012年287-2]
- Lentinan (LNT), a beta-glucan from the fruiting bodies of Lentinus edodes, is well known to have immunomodulatory activity. NO and TNF-alpha are associated with many inflammatory diseases. In this study, we investigated ...
- Biosynthesis of UDP-4-keto-6-deoxyglucose and UDP-rhamnose in Pathogenic Fungi Magnaporthe grisea and Botryotinia fuckeliana
[作者:Martinez, V; Ingwers, M; Smith, J; Glushka, J; Yang, T; Bar-Peled, M,期刊:Journal of Biological Chemistry, 页码:879-892 , 文章类型: Article,,卷期:2012年287-2]
- There is increasing evidence that in several fungi, rhamnose-containing glycans are involved in processes that affect hostpathogen interactions, including adhesion, recognition, virulence, and biofilm formation. Neverthe...
- Evidence for Irreversible Inhibition of Glycogen Synthase Kinase-3 beta by Tideglusib
[作者:Dominguez, JM; Fuertes, A; Orozco, L; del Monte-Millan, M; Delgado, E; Medina, M,期刊:Journal of Biological Chemistry, 页码:893-904 , 文章类型: Article,,卷期:2012年287-2]
- Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy. Sustained oral administration of the compound to a variety of animal models...
- Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells
[作者:Masola, V; Gambaro, G; Tibaldi, E; Brunati, AM; Gastaldello, A; D'Angelo, A; Onisto, M; Lupo, A,期刊:Journal of Biological Chemistry, 页码:1478-1488 , 文章类型: Article,,卷期:2012年287-2]
- The epithelial-mesenchymal transition (EMT) of proximal tubular epithelial cells (PTECs) into myofibroblasts contributes to the establishment of fibrosis that leads to end stage renal disease. FGF-2 induces EMT in PTECs....
- Importance of the Protein Framework for Catalytic Activity of [FeFe]-Hydrogenases
[作者:Knorzer, P; Silakov, A; Foster, CE; Armstrong, FA; Lubitz, W; Happe, T,期刊:Journal of Biological Chemistry, 页码:1489-1499 , 文章类型: Article,,卷期:2012年287-2]
- The active center (H-cluster) of [FeFe]-hydrogenases is embedded into a hydrophobic pocket within the protein. We analyzed several amino acids, located in the vicinity of this niche, by site-directed mutagenesis of the [...
- CENP-E Kinesin Interacts with SKAP Protein to Orchestrate Accurate Chromosome Segregation in Mitosis
[作者:Huang, YJ; Wang, WW; Yao, P; Wang, XW; Liu, X; Zhuang, XX; Yan, F; Zhou, JH; Du, J; Ward, T; Zou, HF; Zhang, JC; Fang, GW; Ding, X; Dou, Z; Yao, XB,期刊:Journal of Biological Chemistry, 页码:1500-1509 , 文章类型: Article,,卷期:2012年287-2]
- Mitotic chromosome segregation is orchestrated by the dynamic interaction of spindle microtubules with the kinetochore. Although previous studies show that the mitotic kinesin CENP-E forms a link between attachment of th...
- BMP2 Protein Regulates Osteocalcin Expression via Runx2-mediated Atf6 Gene Transcription
[作者:Jang, WG; Kim, EJ; Kim, DK; Ryoo, HM; Lee, KB; Kim, SH; Choi, HS; Koh, JT,期刊:Journal of Biological Chemistry, 页码:905-915 , 文章类型: Article,,卷期:2012年287-2]
- Bone morphogenetic protein 2 (BMP2) activates unfolded protein response (UPR) transducers, such as PERK and OASIS, in osteoblast cells. ATF6, a bZIP transcription factor, is also a UPR transducer. However, the involvemen...
- Defining the Disulfide Bonds of Insulin-like Growth Factor-binding Protein-5 by Tandem Mass Spectrometry with Electron Transfer Dissociation and Collision-induced Dissociation
[作者:Nili, M; Mukherjee, A; Shinde, U; David, L; Rotwein, P,期刊:Journal of Biological Chemistry, 页码:1510-1519 , 文章类型: Article,,卷期:2012年287-2]
- The six high-affinity insulin-like growth factor-binding proteins (IGFBPs) comprise a conserved family of secreted molecules that modulate IGF actions by regulating their half-life and access to signaling receptors, and ...
- High Temperature Requirement Factor A1 (HTRA1) Gene Regulates Angiogenesis through Transforming Growth Factor-beta Family Member Growth Differentiation Factor 6
[作者:Zhang, L; Lim, SL; Du, HJ; Zhang, M; Kozak, I; Hannum, G; Wang, XL; Ouyang, H; Hughes, G; Zhao, L; Zhu, XM; Lee, C; Su, ZG; Zhou, XR; Shaw, R; Geum, DH; Wei, XR; Zhu, J; Ideker, T; Oka, C; Wang, NL; Yang, ZL; Shaw, PX; Zhang, K,期刊:Journal of Biological Chemistry, 页码:1520-1526 , 文章类型: Article,,卷期:2012年287-2]
- Genome-wide association study (GWAS) has identified genetic variants in the promoter region of the high temperature requirement factor A1 (HTRA1) gene associated with age-related macular degeneration (AMD). As a secreted...
- MicroRNA let-7c Suppresses Androgen Receptor Expression and Activity via Regulation of Myc Expression in Prostate Cancer Cells
[作者:Nadiminty, N; Tummala, R; Lou, W; Zhu, YZ; Zhang, J; Chen, XB; White, RWD; Kung, HJ; Evans, CP; Gao, AC,期刊:Journal of Biological Chemistry, 页码:1527-1537 , 文章类型: Article,,卷期:2012年287-2]
- Castration-resistant prostate cancer continues to rely on androgen receptor (AR) expression. AR plays a central role in the development of prostate cancer and progression to castration resistance during and after androge...
- Characterization of Galacturonosyl Transferase Genes rgtA, rgtB, rgtC, rgtD, and rgtE Responsible for Lipopolysaccharide Synthesis in Nitrogen-fixing Endosymbiont Rhizobium leguminosarum LIPOPOLYSACCHARIDE CORE AND LIPID GALACTURONOSYL RESIDUES CONFER MEMBRANE STABILITY
[作者:Brown, DB; Forsberg, LS; Kannenberg, EL; Carlson, RW,期刊:Journal of Biological Chemistry, 页码:935-949 , 文章类型: Article,,卷期:2012年287-2]
- Rhizobium lipopolysaccharide (LPS) contains four terminally linked galacturonic acid (GalA) residues; one attached to the lipid A and three attached to the core oligosaccharide moiety. Attachment of the GalA residues req...
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