- Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope.
[作者:Zhou, ZC; Du, XL; Cai, Z; Song, XM; Zhang, HT; Mizuno, T; Suzuki, E; Yee, MR; Berezov, A; Murali, R; Wu, SL; Karger, BL; Greene, MI; Wang, Q,期刊:Journal of Biological Chemistry, 页码:5317-5326 , 文章类型: Article,,卷期:2012年287-8]
- The SUN (Sad1-UNC-84 homology) domain is conserved in a number of nuclear envelope proteins involved in nuclear migration, meiotic telomere tethering, and antiviral responses. The LINC (linker of nucleoskeleton and cytos...
- c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G
[作者:Rafiq, K; Guo, JF; Vlasenko, L; Guo, XJ; Kolpakov, MA; Sanjay, A; Houser, SR; Sabri, A,期刊:Journal of Biological Chemistry, 页码:5327-5339 , 文章类型: Article,,卷期:2012年287-8]
- The neutrophil-derived serine protease, cathepsin G (Cat. G), has been shown to induce myocyte detachment and apoptosis by anoikis through down-regulation of focal adhesion (FA) signaling. However, the mechanisms that co...
- A Chemokine Receptor CXCR2 Macromolecular Complex Regulates Neutrophil Functions in Inflammatory Diseases
[作者:Wu, YN; Wang, S; Farooq, SM; Castelvetere, MP; Hou, YN; Gao, JL; Navarro, JV; Oupicky, D; Sun, F; Li, CY,期刊:Journal of Biological Chemistry, 页码:5744-5755 , 文章类型: Article,,卷期:2012年287-8]
- Inflammation plays an important role in a wide range of human diseases such as ischemia-reperfusion injury, arteriosclerosis, cystic fibrosis, inflammatory bowel disease, etc. Neutrophilic accumulation in the inflamed ti...
- Retagging Identifies Dendritic Cell-specific Intercellular Adhesion Molecule-3 (ICAM3)-grabbing Non-integrin (DC-SIGN) Protein as a Novel Receptor for a Major Allergen from House Dust Mite
[作者:Emara, M; Royer, PJ; Mahdavi, J; Shakib, F; Ghaemmaghami, AM,期刊:Journal of Biological Chemistry, 页码:5756-5763 , 文章类型: Article,,卷期:2012年287-8]
- Dendritic cells (DCs) have been shown to play a key role in the initiation and maintenance of immune responses to microbial pathogens as well as to allergens, but the exact mechanisms of their involvement in allergic res...
- Toxin-Antitoxin Systems of Mycobacterium smegmatis Are Essential for Cell Survival
[作者:Frampton, R; Aggio, RBM; Villas-Boas, SG; Arcus, VL; Cook, GM,期刊:Journal of Biological Chemistry, 页码:5340-5356 , 文章类型: Article,,卷期:2012年287-8]
- The role of chromosomal toxin-antitoxin (TA) modules in bacterial physiology remains enigmatic despite their abundance in the genomes of many bacteria. Mycobacterium smegmatis contains three putative TA systems, VapBC, M...
- Defining Function of Lipopolysaccharide O-antigen Ligase WaaL Using Chemoenzymatically Synthesized Substrates
[作者:Han, WQ; Wu, BL; Li, L; Zhao, GH; Woodward, R; Pettit, N; Cai, L; Thon, V; Wang, PG,期刊:Journal of Biological Chemistry, 页码:5357-5365 , 文章类型: Article,,卷期:2012年287-8]
- The WaaL-mediated ligation of O-antigen onto the core region of the lipid A-core block is an important step in the lipopolysaccharide (LPS) biosynthetic pathway. Although the LPS biosynthesis has been largely characteriz...
- The Receptor Tyrosine Kinase EphA2 Is a Direct Target Gene of Hypermethylated in Cancer 1 (HIC1)
[作者:Foveau, B; Boulay, G; Pinte, S; Van Rechem, C; Rood, BR; Leprince, D,期刊:Journal of Biological Chemistry, 页码:5366-5378 , 文章类型: Article,,卷期:2012年287-8]
- The tumor suppressor gene hypermethylated in cancer 1 (HIC1), which encodes a transcriptional repressor, is epigenetically silenced in many human tumors. Here, we show that ectopic expression of HIC1 in the highly malign...
- Loss of Hypermethylated in Cancer 1 (HIC1) in Breast Cancer Cells Contributes to Stress-induced Migration and Invasion through beta-2 Adrenergic Receptor (ADRB2) Misregulation
[作者:Boulay, G; Malaquin, N; Loison, I; Foveau, B; Van Rechem, C; Rood, BR; Pourtier, A; Leprince, D,期刊:Journal of Biological Chemistry, 页码:5379-5389 , 文章类型: Article,,卷期:2012年287-8]
- The transcriptional repressor HIC1 (Hypermethylated in Cancer 1) is a tumor suppressor gene inactivated in many human cancers including breast carcinomas. In this study, we show that HIC1 is a direct transcriptional repr...
- Mass Spectrometry-assisted Study Reveals That Lysine Residues 1967 and 1968 Have Opposite Contribution to Stability of Activated Factor VIII
[作者:Bloem, E; Meems, H; van den Biggelaar, M; Van der Zwaan, C; Mertens, K; Meijer, AB,期刊:Journal of Biological Chemistry, 页码:5775-5783 , 文章类型: Article,,卷期:2012年287-8]
- The A2 domain rapidly dissociates from activated factor VIII (FVIIIa) resulting in a dampening of the activity of the activated factor X-generating complex. The amino acid residues that affect A2 domain dissociation are ...
- Dimerization and Cytoplasmic Localization Regulate Hippo Kinase Signaling Activity in Organ Size Control
[作者:Jin, YY; Dong, L; Lu, Y; Wu, WQ; Hao, Q; Zhou, ZC; Jiang, J; Zhao, Y; Zhang, L,期刊:Journal of Biological Chemistry, 页码:5784-5796 , 文章类型: Article,,卷期:2012年287-8]
- The Hippo (Hpo) signaling pathway controls organ size by regulating the balance between cell proliferation and apoptosis. Although the Hpo function is conserved, little is known about the mechanism of how its kinase acti...
- Calpain-mediated Degradation of Myocyte Enhancer Factor 2D Contributes to Excitotoxicity by Activation of Extrasynaptic N-Methyl-D-aspartate Receptors
[作者:Wei, GZ; Yin, Y; Li, WM; Bito, H; She, H; Mao, ZX,期刊:Journal of Biological Chemistry, 页码:5797-5805 , 文章类型: Article,,卷期:2012年287-8]
- Synaptic and extrasynaptic NMDA receptors (NMDARs) appear to play opposite roles in neuronal survival and death. Here we report the new findings on the dysregulation of survival factor, myocyte enhancer factor 2D (MEF2D)...
- Protein Arginine Methyltransferase 1-directed Methylation of Kaposi Sarcoma-associated Herpesvirus Latency-associated Nuclear Antigen
[作者:Campbell, M; Chang, PC; Huerta, S; Izumiya, C; Davis, R; Tepper, CG; Kim, KY; Shevchenko, B; Wang, DH; Jung, JU; Luciw, PA; Kung, HJ; Izumiya, Y,期刊:Journal of Biological Chemistry, 页码:5806-5818 , 文章类型: Article,,卷期:2012年287-8]
- The Kaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is a multifunctional protein with roles in gene regulation and maintenance of viral latency. Post-translational modification of L...
- Nuclear Factor Erythroid-derived 2 (Nfe2) Regulates JunD DNA-binding Activity via Acetylation A NOVEL MECHANISM REGULATING TROPHOBLAST DIFFERENTIATION
[作者:Kashif, M; Hellwig, A; Hashemolhosseini, S; Kumar, V; Bock, F; Wang, HJ; Shahzad, K; Ranjan, S; Wolter, J; Madhusudhan, T; Bierhaus, A; Nawroth, P; Isermann, B,期刊:Journal of Biological Chemistry, 页码:5400-5411 , 文章类型: Article,,卷期:2012年287-8]
- We recently demonstrated that the bZip transcription factor nuclear factor erythroid-derived 2 (Nfe2) represses protein acetylation and expression of the transcription factor glial cell missing 1 (Gcm1) in trophoblast ce...
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