- Activation of spleen tyrosine kinase is required for TNF-alpha-induced endothelin-1 upregulation in human aortic endothelial cells
[作者:Kim, YJ; Koo, TY; Yang, WS; Han, NJ; Jeong, JU; Lee, SK; Park, SK,期刊:FEBS Letters, 页码:818-826 , 文章类型: Article,,卷期:2012年586-6]
- Endothelin-1 (ET-1) promotes atherosclerosis. We tested whether spleen tyrosine kinase (Syk) mediates tumor necrosis factor-alpha (TNF-alpha)-induced ET-1 upregulation in human aortic endothelial cells (HAECs) and sought...
- Adaptive diversity of innate immune receptor family short pentraxins in Murinae
[作者:Li, Y; Robins, JH; Ye, JP; Huang, ZY; Wen, Q; Zhang, GJ,期刊:FEBS Letters, 页码:798-803 , 文章类型: Article,,卷期:2012年586-6]
- The short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) constitute a group of innate immune receptors that trigger immune activation by detecting molecules of the microbial cell wall. Here, we e...
- LY294002 inhibits TLR3/4-mediated IFN-beta production via inhibition of IRF3 activation with a PI3K-independent mechanism
[作者:Zhao, W; Qi, JN; Wang, LJ; Zhang, M; Wang, P; Gao, CJ,期刊:FEBS Letters, 页码:705-710 , 文章类型: Article,,卷期:2012年586-6]
- TLR3 and TLR4 utilize adaptor TRIF to activate interferon regulatory factor 3 (IRF3), resulting in interferon beta (IFN-beta) production to mediate anti-viral infection. In this report, we analyzed the effect of two know...
- Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes
[作者:Serrano, GCD; Figueira, TRES; Kiyota, E; Zanata, N; Arruda, P,期刊:FEBS Letters, 页码:905-911 , 文章类型: Article,,卷期:2012年586-6]
- Lysine degradation through the saccharopine pathway has been shown only in plants and animals. Here, we show that bacteria possess the genes encoding lysine-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (S...
- Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination
[作者:Esposito, C; Cantisani, M; D'Auria, G; Falcigno, L; Pedone, E; Galdiero, S; Berisio, R,期刊:FEBS Letters, 页码:659-667 , 文章类型: Article,,卷期:2012年586-6]
- HBHA is a cell-surface protein implicated in the dissemination of Mycobacterium tuberculosis (Mtb) from the site of primary infection. Its N-terminal coiled-coil region is also involved in bacterial agglutination. Howeve...
- Asp563 of the horizontal helix of subunit NuoL is involved in proton translocation by the respiratory complex
[作者:Steimle, S; Willistein, M; Hegger, P; Janoschke, M; Erhardt, H; Friedrich, T,期刊:FEBS Letters, 页码:699-704 , 文章类型: Article,,卷期:2012年586-6]
- The NADH: ubiquinone oxidoreductase couples the electron transfer from NADH to ubiquinone with the translocation of protons across the membrane. It contains a 110 angstrom long helix running parallel to the membrane part...
- MicroRNA-203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin
[作者:Bian, K; Fan, J; Zhang, X; Yang, XW; Zhu, HY; Wang, L; Sun, JY; Meng, YL; Cui, PC; Cheng, SY; Zhang, J; Zhao, J; Yang, AG; Zhang, R,期刊:FEBS Letters, 页码:804-809 , 文章类型: Article,,卷期:2012年586-6]
- Previous studies have shown that miR-203 acts as a tumor-suppressive microRNA in various cancers, but its roles in laryngeal carcinoma are still contradicted. Here, we found that miR-203 inhibited the growth of laryngeal...
- MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans
[作者:Masuda, H; Nakamura, K; Takata, N; Itoh, B; Hirose, T; Moribe, H; Mekada, E; Okada, M,期刊:FEBS Letters, 页码:740-746 , 文章类型: Article,,卷期:2012年586-6]
- The transmembrane protein MIG-13 is a key regulator required for anterior migration of neural cells in Caenorhabditis elegans, but the signaling mechanisms involved remain unknown. Here, we isolated a suppressor mutation...
- Use of Kikume green-red fusions to study the influence of pharmacological chaperones on trafficking of G protein-coupled receptors
[作者:Ridelis, I; Schmidt, A; Teichmann, A; Furkert, J; Wiesner, B; Schulein, R,期刊:FEBS Letters, 页码:784-791 , 文章类型: Article,,卷期:2012年586-6]
- In this study we demonstrate that the photoconvertible monomeric Kikume green-red (mKikGR) protein is suitable to study trafficking of G protein-coupled receptors. Taking mKikGR-tagged mutants of the vasopressin V-2 rece...
- ATX and LPA receptor 3 are coordinately up-regulated in lipopolysaccharide-stimulated THP-1 cells through PKR and SPK1-mediated pathways
[作者:Li, S; Xiong, CY; Zhang, JJ,期刊:FEBS Letters, 页码:792-797 , 文章类型: Article,,卷期:2012年586-6]
- Lysophosphatidic acid (LPA) is an important phospholipid mediator in inflammation and immunity. Previously, we showed that autotaxin (ATX), the enzyme producing LPA from lysophosphatidylcholine (LPC), is induced by LPS i...
- miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells
[作者:Kang, HW; Wang, F; Wei, Q; Zhao, YF; Liu, M; Li, X; Tang, H,期刊:FEBS Letters, 页码:897-904 , 文章类型: Article,,卷期:2012年586-6]
- miR-20a is an important member of the miR-17-92 cluster, and its real function in cervical cancer cells is unknown. Our study demonstrated that miR-20a was upregulated in cervical cancer tissues. Overexpression of miR-20...
- MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3
[作者:Huang, N; Lin, J; Ruan, J; Su, N; Qing, RZ; Liu, FY; He, BF; Lv, CW; Zheng, DY; Luo, RC,期刊:FEBS Letters, 页码:884-891 , 文章类型: Article,,卷期:2012年586-6]
- MicroRNAs (miRNAs) have been linked to the molecular pathogenesis of many cancers. In this study, we found that miR-219-5p was significantly downregulated in 83 HCC tissues and three HCC cell lines, compared to their non...
- Ycf1p attenuates basal level oxidative stress response in Saccharomyces cerevisiae
[作者:Paumi, CM; Pickin, KA; Jarrar, R; Herren, CK; Cowley, ST,期刊:FEBS Letters, 页码:847-853 , 文章类型: Article,,卷期:2012年586-6]
- Ycf1p function is regulated by casein kinase 2 alpha, Cka1p, via phosphorylation of Ser251. Cka1p-mediated phosphorylation of Ycf1p is attenuated in response to high salt stress. Previous results from our lab suggest a r...
|