- Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti T-Cell Receptor Antibody V beta 13 as a Therapeutic Target and Biomarker
[作者：Liu, ZJ; Cort, L; Eberwine, R; Herrmann, T; Leif, JH; Greiner, DL; Yahalom, B; Blankenhorn, EP; Mordes, JP,期刊：Diabetes, 页码：1160-1168 , 文章类型： Article，,卷期：2012年61-5]
- In earlier studies of the Iddm14 diabetes susceptibility locus in the rat, we identified an allele of the T-cell receptor (TCR) beta-chain, Tcrb-V13S1A1, as a candidate gene. To establish its importance, we treated susce...
- Following the Fate of One Insulin-Reactive CD4 T cell Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice
[作者：Fousteri, G; Jasinski, J; Dave, A; Nakayama, M; Pagni, P; Lambolez, F; Juntti, T; Sarikonda, G; Cheng, Y; Croft, M; Cheroutre, H; Eisenbarth, G; von Herrath, M,期刊：Diabetes, 页码：1169-1179 , 文章类型： Article，,卷期：2012年61-5]
- In diabetic patients and susceptible mice, insulin is a targeted autoantigen. Insulin B chain 9-23 (B:9-23) autoreactive CD4 T cells are key for initiating autoimmune diabetes in NOD mice; however, little is known regard...
- Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice
[作者：Yi, SN; Ji, M; Wu, JJ; Ma, XQ; Phillips, P; Hawthorne, WJ; O'Connell, PJ,期刊：Diabetes, 页码：1180-1191 , 文章类型： Article，,卷期：2012年61-5]
- T cell-mediated rejection remains a barrier to the clinical application of islet xenotransplantation. Regulatory T cells (Treg) regulate immune responses by suppressing effector T cells. This study aimed to determine the...
- Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes A Twin and Population Study
[作者：Beyan, H; Riese, H; Hawa, MI; Beretta, G; Davidson, HW; Hutton, JC; Burger, H; Schlosser, M; Snieder, H; Boehm, BO; Leslie, RD,期刊：Diabetes, 页码：1192-1198 , 文章类型： Article，,卷期：2012年61-5]
- In type 1 diabetes, diabetes-associated autoantibodies, including islet cell antibodies (ICAs), reflect adaptive immunity, while increased serum N-epsilon-carboxymethyl-lysine (CML), an advanced glycation end product, is...
- The Radioprotective 105/MD-1 Complex Contributes to Diet-Induced Obesity and Adipose Tissue Inflammation
[作者：Watanabe, Y; Nakamura, T; Ishikawa, S; Fujisaka, S; Usui, I; Tsuneyama, K; Ichihara, Y; Wada, T; Hirata, Y; Suganami, T; Izaki, H; Akira, S; Miyake, K; Kanayama, H; Shimabukuro, M; Sata, M; Sasaoka, T; Ogawa, Y; Tobe, K; Takatsu, K; Nagai, Y,期刊：Diabetes, 页码：1199-1209 , 文章类型： Article，,卷期：2012年61-5]
- Recent accumulating evidence suggests that innate immunity is associated with obesity-induced chronic inflammation and metabolic disorders. Here, we show that a Toll-like receptor (TLR) protein, radioprotective 105 (RP10...
- Short-Term Hyperinsulinemia and Hyperglycemia Increase Myocardial Lipid Content in Normal Subjects
[作者：Winhofer, Y; Krssak, M; Jankovic, D; Anderwald, CH; Reiter, G; Hofer, A; Trattnig, S; Luger, A; Krebs, M,期刊：Diabetes, 页码：1210-1216 , 文章类型： Article，,卷期：2012年61-5]
- Increased myocardial lipid content (MYCL) recently has been linked to the development of cardiomyopathy in diabetes. In contrast to steatosis in skeletal muscle and liver, previous investigations could not confirm a link...
- Metabolic Alterations Induced by Sucrose Intake and Alzheimer's Disease Promote Similar Brain Mitochondrial Abnormalities
[作者：Carvalho, C; Cardoso, S; Correia, SC; Santos, RX; Santos, MS; Baldeiras, I; Oliveira, CR; Moreira, PI,期刊：Diabetes, 页码：1234-1242 , 文章类型： Article，,卷期：2012年61-5]
- Evidence shows that diabetes increases the risk of developing Alzheimer's disease (AD). Many efforts have been done to elucidate the mechanisms linking diabetes and AD. To demonstrate that mitochondria may represent a fu...
- The Human GLP-1 Analog Liraglutide and the Pancreas Evidence for the Absence of Structural Pancreatic Changes in Three Species
[作者：Nyborg, NCB; Molck, AM; Madsen, LW; Knudsen, LB,期刊：Diabetes, 页码：1243-1249 , 文章类型： Article，,卷期：2012年61-5]
- Glucagon-like peptide (GLP)-1 analogs have been implicated as a risk factor for pancreatitis in humans. We investigated whether liraglutide, the once-daily human GLP-1 analog, induces pancreatitis in rats, mice, and monk...
- Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the Kras(G12D) Mouse Model
[作者：Gier, B; Matveyenko, AV; Kirakossian, D; Dawson, D; Dry, SM; Butler, PC,期刊：Diabetes, 页码：1250-1262 , 文章类型： Article，,卷期：2012年61-5]
- Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of...
- A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control
[作者：Bhaskar, V; Goldfine, ID; Bedinger, DH; Lau, A; Kuan, HF; Gross, LM; Handa, M; Maddux, BA; Watson, SR; Zhu, SL; Narasimha, AJ; Levy, R; Webster, L; Wijesuriya, SD; Liu, NC; Wu, XR; Chemla-Vogel, D; Tran, C; Lee, SR; Wong, S; Wilcock, D; White, ML; Corbin, JA,期刊：Diabetes, 页码：1263-1271 , 文章类型： Article，,卷期：2012年61-5]
- Many patients with diabetes mellitus (both type 1 and type 2) require therapy to maintain normal fasting glucose levels. To develop a novel treatment for these individuals, we used phage display technology to target the ...
|