- Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies
[作者：Gupta, M; Hendrickson, AEW; Yun, SS; Han, JJ; Schneider, PA; Koh, BD; Stenson, MJ; Wellik, LE; Shing, JC; Peterson, KL; Flatten, KS; Hess, AD; Smith, BD; Karp, JE; Barr, S; Witzig, TE; Kaufmann, SH,期刊：Blood, 页码：476-487 , 文章类型： Article，,卷期：2012年119-2]
- The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active i...
- Immunohistochemistry in the classification of systemic forms of amyloidosis: a systematic investigation of 117 patients
[作者：Schonland, SO; Hegenbart, U; Bochtler, T; Mangatter, A; Hansberg, M; Ho, AD; Lohse, P; Rocken, C,期刊：Blood, 页码：488-493 , 文章类型： Article，,卷期：2012年119-2]
- Amyloidoses are characterized by organ deposition of misfolded proteins. This study evaluated immunohistochemistry as a diagnostic tool for the differentiation of amyloid subentities, which is warranted for accurate trea...
- An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification
[作者：Stephens, OW; Zhang, Q; Qu, PP; Zhou, YM; Chavan, S; Tian, EM; Williams, DR; Epstein, J; Barlogie, B; Shaughnessy, JD,期刊：Blood, 页码：503-512 , 文章类型： Article，,卷期：2012年119-2]
- IL-6 signaling can be enhanced through transsignaling by the soluble IL-6 receptor (sIL-6r), allowing for the pleiotropic cytokine to affect cells it would not ordinarily have an effect on. Serum levels of sIL-6r can be ...
- miR-155 regulates HGAL expression and increases lymphoma cell motility
[作者：Dagan, LN; Jiang, XY; Bhatt, S; Cubedo, E; Rajewsky, K; Lossos, IS,期刊：Blood, 页码：513-520 , 文章类型： Article，,卷期：2012年119-2]
- HGAL, a prognostic biomarker in patients with diffuse large B-cell lymphoma and classic Hodgkin lymphoma, inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade and interacting with actin...
- Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
[作者：Rossi, D; Rasi, S; Fabbri, G; Spina, V; Fangazio, M; Forconi, F; Marasca, R; Laurenti, L; Bruscaggin, A; Cerri, M; Monti, S; Cresta, S; Fama, R; De Paoli, L; Bulian, P; Gattei, V; Guarini, A; Deaglio, S; Capello, D; Rabadan, R; Pasqualucci, L; Dalla-Favera, R; Foa, R; Gaidano, G,期刊：Blood, 页码：521-529 , 文章类型： Article，,卷期：2012年119-2]
- Analysis of the chronic lymphocytic leukemia (CLL) coding genome has recently disclosed that the NOTCH1 proto-oncogene is recurrently mutated at CLL presentation. Here, we assessed the prognostic role of NOTCH1 mutations...
- Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib
[作者：Kumari, A; Brendel, C; Hochhaus, A; Neubauer, A; Burchert, A,期刊：Blood, 页码：530-539 , 文章类型： Article，,卷期：2012年119-2]
- BCR-ABL overexpression and stem cell quiescence supposedly contribute to the failure of imatinib mesylate (IM) to eradicate chronic myeloid leukemia (CML). However, BCR-ABL expression levels of persisting precursors and ...
- Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia
[作者：Frisch, BJ; Ashton, JM; Xing, LP; Becker, MW; Jordan, CT; Calvi, LM,期刊：Blood, 页码：540-550 , 文章类型： Article，,卷期：2012年119-2]
- Pancytopenia is a major cause of morbidity in acute myeloid leukemia (AML), yet its cause is unclear. Normal osteoblastic cells have been shown to support hematopoiesis. To define the effects of leukemia on osteoblastic ...
- Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies
[作者：Kayser, S; Zucknick, M; Dohner, K; Krauter, J; Kohne, CH; Horst, HA; Held, G; von Lilienfeld-Toal, M; Wilhelm, S; Rummel, M; Germing, U; Gotze, K; Nachbaur, D; Schlegelberger, B; Gohring, G; Spath, D; Morlok, C; Teleanu, V; Ganser, A; Dohner, H; Schlenk, RF,期刊：Blood, 页码：551-558 , 文章类型： Article，,卷期：2012年119-2]
- We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia (AML) in the context of the current World Health Organization (WHO) classification and to evaluate the outcome of MK(+) pa...
- DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications
[作者：Hou, HA; Kuo, YY; Liu, CY; Chou, WC; Lee, MC; Chen, CY; Lin, LI; Tseng, MH; Huang, CF; Chiang, YC; Lee, FY; Liu, MC; Liu, CW; Tang, JL; Yao, M; Huang, SY; Ko, BS; Hsu, SC; Wu, SJ; Tsay, W; Chen, YC; Tien, HF,期刊：Blood, 页码：559-568 , 文章类型： Article，,卷期：2012年119-2]
- DNMT3A mutations are associated with poor prognosis in acute myeloid leukemia (AML), but the stability of this mutation during the clinical course remains unclear. In the present study of 500 patients with de novo AML, D...
- SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value
[作者：Patnaik, MM; Lasho, TL; Hodnefield, JM; Knudson, RA; Ketterling, RP; Garcia-Manero, G; Steensma, DP; Pardanani, A; Hanson, CA; Tefferi, A,期刊：Blood, 页码：569-572 , 文章类型： Article，,卷期：2012年119-2]
- SF3B1 mutations were recently reported in myelodysplastic syndromes (MDSs), especially in the presence of ring sideroblasts (RSs). We sought to define the interaction between SF3B1 mutations, morphology, karyotype, and p...
- ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes
[作者：Csepanyi-Komi, R; Sirokmany, G; Geiszt, M; Ligeti, E,期刊：Blood, 页码：573-582 , 文章类型： Article，,卷期：2012年119-2]
- Members of the Rac/Rho family of small GTPases play an essential role in phagocytic cells in organization of the actin cytoskeleton and production of toxic oxygen compounds. GTPase-activating proteins (GAPs) decrease the...
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