- Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4(+) T-Cell Subsets
[作者:Wang, JP; Ren, ZH; Xu, YM; Xiao, S; Meydani, SN; Wu, DY,期刊:American Journal of Pathology, 页码:221-234 , 文章类型: Article,,卷期:2012年180-1]
- The green tea component epigallocatechin-3-gallate (EGCG) may be beneficial in autoimmune diseases; however, the underlying mechanisms are not well understood. In this study, we determined the effect of EGCG on the devel...
- Persistent Inflammation Subverts Thrombospondin-1-Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation
[作者:Chen, M; Copland, DA; Zhao, JW; Liu, J; Forrester, JV; Dick, AD; Xu, HP,期刊:American Journal of Pathology, 页码:235-245 , 文章类型: Article,,卷期:2012年180-1]
- Neovascular retinal disease is a leading cause of blindness orchestrated by inflammatory responses. Although noninfectious uveoretinitis is mediated by CD4(+) T cells, in the persistent phase of disease, angiogenic respo...
- Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APCMin/+ Mice
[作者:Woo, DK; Green, PD; Santos, JH; D'Souza, AD; Walther, Z; Martin, WD; Christian, BE; Chandel, NS; Shadel, GS,期刊:American Journal of Pathology, 页码:24-31 , 文章类型: Article,,卷期:2012年180-1]
- Alterations in mitochondrial oxidative phosphorylation have long been documented in tumors. Other types of mitochondrial dysfunction, including altered reactive oxygen species (ROS) production and apoptosis, also can con...
- Platelet-Activating Factor Receptor Is Essential for the Development of Experimental Cerebral Malaria
[作者:Lacerda-Queiroz, N; Rodrigues, DH; Vilela, MC; Rachid, MA; Soriani, FM; Sousa, LP; Campos, RDL; Quesniaux, VFJ; Teixeira, MM; Teixeira, AL,期刊:American Journal of Pathology, 页码:246-255 , 文章类型: Article,,卷期:2012年180-1]
- Cerebral malaria is a severe form of the disease that may result, in part, from an overt inflammatory response during infection by Plasmodium falciparum. The understanding of the pathogenesis of cerebral malaria may aid ...
- Minor Histocompatibility Antigens Are Expressed in Syncytiotrophoblast and Trophoblast Debris Implications for Maternal Alloreactivity to the Fetus
[作者:Holland, OJ; Linscheid, C; Hodes, HC; Nauser, TL; Gilliam, M; Stone, P; Chamley, LW; Petroff, MG,期刊:American Journal of Pathology, 页码:256-266 , 文章类型: Article,,卷期:2012年180-1]
- The fetal semi-allograft can induce expansion and tolerance of antigen-specific maternal T and B cells through paternally inherited major histocompatibility complex and minor histocompatibility antigens (mHAgs). The effe...
- Modulation of Autoimmune Demyelination by Laquinimod via Induction of Brain-Derived Neurotrophic Factor
[作者:Thone, J; Ellrichmann, G; Seubert, S; Peruga, I; Lee, DH; Conrad, R; Hayardeny, L; Comi, G; Wiese, S; Linker, RA; Gold, R,期刊:American Journal of Pathology, 页码:267-274 , 文章类型: Article,,卷期:2012年180-1]
- Laquinimod is a promising, orally available compound that has been successfully evaluated in placebo-controlled phase HMI studies of relapsing-remitting multiple sclerosis (MS). Studies are ongoing to further define laqu...
- TLR4 Activity Is Required in the Resolution of Pulmonary Inflammation and Fibrosis after Acute and Chronic Lung Injury
[作者:Yang, HZ; Wang, JP; Mi, S; Liu, HZ; Cui, B; Yan, HM; Yan, J; Li, Z; Liu, H; Hua, F; Lu, WG; Hu, ZW,期刊:American Journal of Pathology, 页码:275-292 , 文章类型: Article,,卷期:2012年180-1]
- Pulmonary fibrosis is an inflammation-driven lung disease with a poor prognosis and no cure. Here we report that basal toll-like receptor 4 (TLR4) activity is critical for the resolution of acute and chronic inflammation...
|