- HIF-2 alpha Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1 alpha Is Repressed
[作者:Persson, MM; Johansson, ME; Monsef, N; Planck, M; Beckman, S; Seckl, MJ; Ronnstrand, L; Pahlman, S; Pettersson, HM,期刊:American Journal of Pathology, 页码:494-504 , 文章类型: Article,,卷期:2012年180-2]
- Small cell lung carcinoma (SCLC) is extremely aggressive and frequently metastasizes widely in its early stage. Because tumor hypoxia is related to aggressive tumor behavior and the hypoxic adaptation of SCLC is poorly d...
- Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury
[作者:Wang, Z; Holthoff, JH; Seely, KA; Pathak, E; Spencer, HJ; Gokden, N; Mayeux, PR,期刊:American Journal of Pathology, 页码:505-516 , 文章类型: Article,,卷期:2012年180-2]
- Acute kidney injury is a frequent and serious complication of sepsis. To better understand the development of sepsis-induced acute kidney injury, we performed the first time-dependent studies to document changes in renal...
- Autophagy Guards Against Cisplatin-Induced Acute Kidney Injury
[作者:Takahashi, A; Kimura, T; Takabatake, Y; Namba, T; Kaimori, J; Kitamura, H; Matsui, I; Niimura, F; Matsusaka, T; Fujita, N; Yoshimori, T; Isaka, Y; Rakugi, H,期刊:American Journal of Pathology, 页码:517-525 , 文章类型: Article,,卷期:2012年180-2]
- Autophagy is a highly conserved bulk protein degradation pathway involved in cellular homeostasis. Although emerging evidence indicates involvement of autophagy in various conditions, efforts to clarify the role of autop...
- Rac1b Increases with Progressive Tau Pathology within Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease
[作者:Perez, SE; Getova, DP; He, B; Counts, SE; Geula, C; Desire, L; Coutadeur, S; Peillon, H; Ginsberg, SD; Mufson, EJ,期刊:American Journal of Pathology, 页码:526-540 , 文章类型: Article,,卷期:2012年180-2]
- Cholinergic basal forebrain (CBF) nucleus basalis (NB) neurons display neurofibrillary tangles (NFTs) during Alzheimer's disease (AD) progression, yet the mechanisms underlying this selective vulnerability are currently ...
- A Rat Model for Studying the Biological Effects of Circulating LDL in the Choriocapillaris-BrM-RPE Complex
[作者:Yin, LL; Shi, YH; Liu, XJ; Zhang, HM; Gong, YY; Gu, Q; Wu, XW; Xu, X,期刊:American Journal of Pathology, 页码:541-549 , 文章类型: Article,,卷期:2012年180-2]
- Retention of apolipoprotein B-containing lipoproteins In Bruch's membrane (BrM) is believed to be important in early age-related macular degeneration (AMD). The origin of the lipoproteins in BrM is a hot topic in (AMD) r...
- Targeted Deletion of Jun/AP-1 in Alveolar Epithelial Cells Causes Progressive Emphysema and Worsens Cigarette Smoke-Induced Lung Inflammation
[作者:Reddy, NM; Vegiraju, S; Irving, A; Paun, BC; Luzina, IG; Atamas, SP; Biswal, S; Ana, NA; Mitzner, W; Reddy, SP,期刊:American Journal of Pathology, 页码:562-574 , 文章类型: Article,,卷期:2012年180-2]
- Chronic obstructive pulmonary disease appears to occur slowly and progressively over many years, with both genetic factors and environmental modifiers contributing to its pathogenesis. Although the c-Jun/activator protei...
- The Influence of Skeletal Muscle on the Regulation of Liver:Body Mass and Liver Regeneration
[作者:Huang, JS; Glauber, M; Qiu, ZH; Gazit, V; Dietzen, DJ; Rudnick, DA,期刊:American Journal of Pathology, 页码:575-582 , 文章类型: Article,,卷期:2012年180-2]
- The relationship between liver and body mass is exemplified by the precision with which the liver:body mass ratio is restored after partial hepatic resection. Nevertheless, the compartments, against which liver mass is s...
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