- Identification of a Novel Feline Picornavirus from the Domestic Cat
[作者:Lau, SKP; Woo, PCY; Yip, CCY; Choi, GKY; Wu, Y; Bai, R; Fan, RYY; Lai, KKY; Chan, KH; Yuen, KY,期刊:Journal of virology, 页码:395-405 , 文章类型: Article,,卷期:2012年86-1]
- While picornaviruses are known to infect different animals, their existence in the domestic cat was unknown. We describe the discovery of a novel feline picornavirus (FePV) from stray cats in Hong Kong. From samples from...
- A Recombinant Chimeric La Crosse Virus Expressing the Surface Glycoproteins of Jamestown Canyon Virus Is Immunogenic and Protective against Challenge with either Parental Virus in Mice or Monkeys
[作者:Bennett, RS; Gresko, AK; Nelson, JT; Murphy, BR; Whitehead, SS,期刊:Journal of virology, 页码:420-426 , 文章类型: Article,,卷期:2012年86-1]
- La Crosse virus (LACV) and Jamestown Canyon virus (JCV), family Bunyaviridae, are mosquito-borne viruses that are endemic in North America and recognized as etiologic agents of encephalitis in humans. Both viruses belong...
- Herpes Simplex Virus Requires Poly(ADP-Ribose) Polymerase Activity for Efficient Replication and Induces Extracellular Signal-Related Kinase-Dependent Phosphorylation and ICP0-Dependent Nuclear Localization of Tankyrase 1
[作者:Li, Z; Yamauchi, Y; Kamakura, M; Murayama, T; Goshima, F; Kimura, H; Nishiyama, Y,期刊:Journal of virology, 页码:492-503 , 文章类型: Article,,卷期:2012年86-1]
- Tankyrase 1 is a poly(ADP-ribose) polymerase (PARP) which localizes to multiple subcellular sites, including telomeres and mitotic centrosomes. Poly(ADP-ribosyl) ation of the nuclear mitotic apparatus (NuMA) protein by t...
- Stimulation of the Human RAD51 Nucleofilament Restricts HIV-1 Integration In Vitro and in Infected Cells
[作者:Cosnefroy, O; Tocco, A; Lesbats, P; Thierry, S; Calmels, C; Wiktorowicz, T; Reigadas, S; Kwon, Y; De Cian, A; Desfarges, S; Bonot, P; San Filippo, J; Litvak, S; Le Cam, E; Rethwilm, A; Fleury, H; Connell, PP; Sung, P; Delelis, O; Andreola, ML; Parissi, V,期刊:Journal of virology, 页码:513-526 , 文章类型: Article,,卷期:2012年86-1]
- Stable HIV-1 replication requires the DNA repair of the integration locus catalyzed by cellular factors. The human RAD51 (hRAD51) protein plays a major role in homologous recombination (HR) DNA repair and was previously ...
- Multiple Viral Ligands Naturally Presented by Different Class I Molecules in Transporter Antigen Processing-Deficient Vaccinia Virus-Infected Cells
[作者:Lorente, E; Infantes, S; Barnea, E; Beer, I; Garcia, R; Lasala, F; Jimenez, M; Vilches, C; Lemonnier, FA; Admon, A; Lopez, D,期刊:Journal of virology, 页码:527-541 , 文章类型: Article,,卷期:2012年86-1]
- The transporter associated with antigen processing (TAP) delivers the viral proteolytic products generated by the proteasome in the cytosol to the endoplasmic reticulum lumen that are subsequently recognized by cytotoxic...
- A Vaccinia Virus-Driven Interplay between the MKK4/7-JNK1/2 Pathway and Cytoskeleton Reorganization
[作者:Pereira, ACTC; Leite, FGG; Brasil, BSAF; Soares-Martins, JAP; Torres, AA; Pimenta, PFP; Souto-Padron, T; Traktman, P; Ferreira, PCP; Kroon, EG; Bonjardim, CA,期刊:Journal of virology, 页码:172-184 , 文章类型: Article,,卷期:2012年86-1]
- Viral manipulation of transduction pathways associated with key cellular functions such as survival, response to microbial infection, and cytoskeleton reorganization can provide the supportive milieu for a productive inf...
- The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice
[作者:Abe, Y; Fujii, K; Nagata, N; Takeuchi, O; Akira, S; Oshiumi, H; Matsumoto, M; Seya, T; Koike, S,期刊:Journal of virology, 页码:185-194 , 文章类型: Article,,卷期:2012年86-1]
- RIG-I-like receptors and Toll-like receptors (TLRs) play important roles in the recognition of viral infections. However, how these molecules contribute to the defense against poliovirus (PV) infection remains unclear. W...
- The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection
[作者:Shinya, K; Ito, M; Makino, A; Tanaka, M; Miyake, K; Eisfeld, AJ; Kawaoka, Y,期刊:Journal of virology, 页码:19-24 , 文章类型: Article,,卷期:2012年86-1]
- Prestimulation of the TLR4 pathway with lipopolysaccharide (LPS) protects mice from lethal infection with H5N1 influenza virus. Here, we reveal that the TLR4-TRIF pathway is required for this protective effect by using m...
- Complex Dynamic Development of Poliovirus Membranous Replication Complexes
[作者:Belov, GA; Nair, V; Hansen, BT; Hoyt, FH; Fischer, ER; Ehrenfeld, E,期刊:Journal of virology, 页码:302-312 , 文章类型: Article,,卷期:2012年86-1]
- Replication of all positive-strand RNA viruses is intimately associated with membranes. Here we utilize electron tomography and other methods to investigate the remodeling of membranes in poliovirus-infected cells. We fo...
- Modification of the Untranslated Regions of Human Enterovirus 71 Impairs Growth in a Cell-Specific Manner
[作者:Kok, CC; Phuektes, P; Bek, E; McMinn, PC,期刊:Journal of virology, 页码:542-552 , 文章类型: Article,,卷期:2012年86-1]
- Human enterovirus 71 (HEV71) is the causative agent of hand, foot, and mouth disease and associated acute neurological disease. At present, little is known about the genetic determinants of HEV71 neurovirulence. Studies ...
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