- The maternal immune response to fetal platelet GPIb alpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies
[作者:Li, CL; Piran, S; Chen, PG; Lang, S; Zarpellon, A; Jin, JW; Zhu, GH; Reheman, A; van der Wal, DE; Simpson, EK; Ni, R; Gross, PL; Ware, J; Ruggeri, ZM; Freedman, J; Ni, HY,期刊:Journal of clinical investigation, 页码:4537-4547 , 文章类型: Article,,卷期:2011年121-11]
- Fetal and neonatal immune thrombocytopenia (FNIT) is a severe bleeding disorder caused by maternal antibody-mediated destruction of fetal/neonatal platelets. It is the most common cause of severe thrombocytopenia in neon...
- Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease
[作者:Ma, WL; Han, WH; Greer, PA; Tuder, RM; Toque, HA; Wang, KKW; Caldwell, RW; Su, YC,期刊:Journal of clinical investigation, 页码:4548-4566 , 文章类型: Article,,卷期:2011年121-11]
- Pulmonary hypertension is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Several growth factors, including EGF, PDGF, and TGF-beta 1, are involved in pulmonary vascular remodel...
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