- Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation
[作者:Bohne, F; Martinez-Llordella, M; Lozano, JJ; Miguel, R; Benitez, C; Londono, MC; Manzia, TM; Angelico, R; Swinkels, DW; Tjalsma, H; Lopez, M; Abraldes, JG; Bonaccorsi-Riani, E; Jaeckel, E; Taubert, R; Pirenne, J; Rimola, A; Tisone, G; Sanchez-Fueyo, A,期刊:Journal of clinical investigation, 页码:368-382 , 文章类型: Article,,卷期:2012年122-1]
- Following organ transplantation, lifelong immunosuppressive therapy is required to prevent the host immune system from destroying the allograft. This can cause severe side effects and increased recipient morbidity and mo...
- Haptoglobin activates innate immunity to enhance acute transplant rejection in mice
[作者:Shen, H; Song, Y; Colangelo, CM; Wu, T; Bruce, C; Scabia, G; Galan, A; Maffei, M; Goldstein, DR,期刊:Journal of clinical investigation, 页码:383-387 , 文章类型: Article,,卷期:2012年122-1]
- Immune tolerance to transplanted organs is impaired when the innate immune system is activated in response to the tissue necrosis that occurs during harvesting and implantation procedures. A key molecule in this immune p...
- Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice
[作者:Lamont, BJ; Li, YZ; Kwan, E; Brown, TJ; Gaisano, H; Drucker, DJ,期刊:Journal of clinical investigation, 页码:388-402 , 文章类型: Article,,卷期:2012年122-1]
- Glucagon-like peptide-1 (GLP-1) circulates at low levels and acts as an incretin hormone, potentiating glucose-dependent insulin secretion from islet beta cells. GLP-1. also modulates gastric emptying and engages neural ...
- Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma
[作者:Avirneni-Vadlamudi, U; Galindo, KA; Endicott, TR; Paulson, V; Cameron, S; Galindo, RL,期刊:Journal of clinical investigation, 页码:403-407 , 文章类型: Article,,卷期:2012年122-1]
- Rhabdomyosarcoma (RMS) is a malignancy of muscle myoblasts, which fail to exit the cell cycle, resist terminal differentiation, and are blocked from fusing into syncytial skeletal muscle. In some patients, RMS is caused ...
- In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology
[作者:Tsai, M; Kita, A; Leach, J; Rounsevell, R; Huang, JN; Moake, J; Ware, RE; Fletcher, DA; Lam, WA,期刊:Journal of clinical investigation, 页码:408-418 , 文章类型: Article,,卷期:2012年122-1]
- In hematologic diseases, such as sickle cell disease (SCD) and hemolytic uremic syndrome (HUS), pathological biophysical interactions among blood cells, endothelial cells, and soluble factors lead to microvascular occlus...
- Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
[作者:Yiakouvaki, A; Dimitriou, M; Karakasiliotis, I; Eftychi, C; Theocharis, S; Kontoyiannis, DL,期刊:Journal of clinical investigation, 页码:48-61 , 文章类型: Article,,卷期:2012年122-1]
- The innate immune response involves a variety of inflammatory reactions that can result in inflammatory disease and cancer if they are not resolved and instead are allowed to persist. The effective activation and resolut...
- Altered CD4(+) T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals
[作者:Mavigner, M; Cazabat, M; Dubois, M; L'Faqihi, FE; Requena, M; Pasquier, C; Klopp, P; Amar, J; Alric, L; Barange, K; Vinel, JP; Marchou, B; Massip, P; Izopet, J; Delobel, P,期刊:Journal of clinical investigation, 页码:62-69 , 文章类型: Article,,卷期:2012年122-1]
- Depletion of CD4(+) T cells from the gut occurs rapidly during acute HIV-1 infection. This has been linked to systemic inflammation and disease progression as a result of translocation of microbial products from the gut ...
- Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice
[作者:Alexander, MR; Moehle, CW; Johnson, JL; Yang, ZY; Lee, JK; Jackson, CL; Owens, GK,期刊:Journal of clinical investigation, 页码:70-79 , 文章类型: Article,,卷期:2012年122-1]
- Clinical complications of atherosclerosis arise primarily as a result of luminal obstruction due to atherosclerotic plaque growth, with inadequate outward vessel remodeling and plaque destabilization leading to rupture. ...
- Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms
[作者:Sakai, K; Yamamoto, A; Matsubara, K; Nakamura, S; Naruse, M; Yamagata, M; Sakamoto, K; Tauchi, R; Wakao, N; Imagama, S; Hibi, H; Kadomatsu, K; Ishiguro, N; Ueda, M,期刊:Journal of clinical investigation, 页码:80-90 , 文章类型: Article,,卷期:2012年122-1]
- Spinal cord injury (SCI) often leads to persistent functional deficits due to loss of neurons and glia and to limited axonal regeneration after injury. Here we report that transplantation of human dental pulp stem cells ...
- Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice
[作者:Shim, JH; Greenblatt, MB; Singh, A; Brady, N; Hu, D; Drapp, R; Ogawa, W; Kasuga, M; Noda, T; Yang, SH; Lee, SK; Rebe, VI; Glimcher, LH,期刊:Journal of clinical investigation, 页码:91-106 , 文章类型: Article,,卷期:2012年122-1]
- Mutations in the coactivator CREB-binding protein (CBP) are a major cause of the human skeletal dysplasia Rubinstein-Taybi syndrome (RTS); however, the mechanism by which these mutations affect skeletal mineralization an...
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