- Short Hairpin RNA Screen Indicates That Klotho Beta/FGF19 Protein Overcomes Stasis in Human Colonic Epithelial Cells
[作者:Kim, J; Eskiocak, U; Stadler, G; Lou, ZJ; Kuro-o, M; Shay, JW; Wright, WE,期刊:Journal of Biological Chemistry, 页码:43294-43300 , 文章类型: Article,,卷期:2011年286-50]
- Normal human colonic epithelial cells (HCECs) are not immortalized by telomerase alone but also require CDK4. Some human cell types growth-arrest due to stress-or aberrant signaling-induced senescence (stasis). Stasis re...
- Alternative Spermidine Biosynthetic Route Is Critical for Growth of Campylobacter jejuni and Is the Dominant Polyamine Pathway in Human Gut Microbiota
[作者:Hanfrey, CC; Pearson, BM; Hazeldine, S; Lee, J; Gaskin, DJ; Woster, PM; Phillips, MA; Michael, AJ,期刊:Journal of Biological Chemistry, 页码:43301-43312 , 文章类型: Article,,卷期:2011年286-50]
- The availability of fully sequenced bacterial genomes has revealed that many species known to synthesize the polyamine spermidine lack the spermidine biosynthetic enzymes S-adenosylmethionine decarboxylase and spermidine...
- NLRP7, a Nucleotide Oligomerization Domain-like Receptor Protein, Is Required for Normal Cytokine Secretion and Co-localizes with Golgi and the Microtubule-organizing Center
[作者:Messaed, C; Akoury, E; Djuric, U; Zeng, JB; Saleh, M; Gilbert, L; Seoud, M; Qureshi, S; Slim, R,期刊:Journal of Biological Chemistry, 页码:43313-43323 , 文章类型: Article,,卷期:2011年286-50]
- A hydatidiform mole (HM) is a human pregnancy with hyperproliferative placenta and abnormal embryonic development. Mutations in NLRP7, a member of the nucleotide oligomerization domain-like receptor family of proteins wi...
- Identification of an Endocytosis Motif in an Intracellular Loop of Wntless Protein, Essential for Its Recycling and the Control of Wnt Protein Signaling
[作者:Gasnereau, I; Herr, P; Chia, PZC; Basler, K; Gleeson, PA,期刊:Journal of Biological Chemistry, 页码:43324-43333 , 文章类型: Article,,卷期:2011年286-50]
- The secretion of Wnt signaling proteins is dependent upon the transmembrane sorting receptor, Wntless (Wls), which recycles between the trans-Golgi network and the cell surface. Loss of Wls results in impairment of Wnt s...
- Cysteine-rich 61-Connective Tissue Growth Factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced Signaling Protein-2 (WISP-2) Regulates MicroRNA-10b via Hypoxia-inducible Factor-1 alpha-TWIST Signaling Networks in Human Breast Cancer Cells
[作者:Haque, I; Banerjee, S; Mehta, S; De, A; Majumder, M; Mayo, MS; Kambhampati, S; Campbell, DR; Banerjee, SK,期刊:Journal of Biological Chemistry, 页码:43475-43485 , 文章类型: Article,,卷期:2011年286-50]
- MicroRNAs (miRNAs) are naturally occurring single-stranded RNA molecules that post-transcriptionally regulate the expression of target mRNA transcripts. Many of these target mRNA transcripts are involved in regulating pr...
- Discovery of a Novel Class of Covalent Inhibitor for Aldehyde Dehydrogenases
[作者:Khanna, M; Chen, CH; Kimble-Hill, A; Parajuli, B; Perez-Miller, S; Baskaran, S; Kim, J; Dria, K; Vasiliou, V; Mochly-Rosen, D; Hurley, TD,期刊:Journal of Biological Chemistry, 页码:43486-43494 , 文章类型: Article,,卷期:2011年286-50]
- Human aldehyde dehydrogenases (ALDHs) comprise a family of 17 homologous enzymes that metabolize different biogenic and exogenic aldehydes. To date, there are relatively few general ALDH inhibitors that can be used to pr...
- Cysteine-dependent Ubiquitination of Pex18p Is Linked to Cargo Translocation across the Peroxisomal Membrane
[作者:Hensel, A; Beck, S; El Magraoui, F; Platta, HW; Girzalsky, W; Erdmann, R,期刊:Journal of Biological Chemistry, 页码:43495-43505 , 文章类型: Article,,卷期:2011年286-50]
- The peroxisomal matrix protein import is facilitated by cycling receptor molecules that shuttle between the cytosol and the peroxisomal membrane. In the yeast Saccharomyces cerevisiae, the import of proteins harboring a ...
- Native Thrombocidin-1 and Unfolded Thrombocidin-1 Exert Antimicrobial Activity via Distinct Structural Elements
[作者:Kwakman, PHS; Krijgsveld, J; de Boer, L; Nguyen, LT; Boszhard, L; Vreede, J; Dekker, HL; Speijer, D; Drijfhout, JW; Velde, AAT; Crielaard, W; Vogel, HJ; Vandenbroucke-Grauls, CMJE; Zaat, SAJ,期刊:Journal of Biological Chemistry, 页码:43506-43514 , 文章类型: Article,,卷期:2011年286-50]
- Chemokines (chemotactic cytokines) can have direct antimicrobial activity, which is apparently related to the presence of a distinct positively charged patch on the surface. However, chemokines can retain antimicrobial a...
- Mimicry of the Regulatory Role of Urokinase in Lamellipodia Formation by Introduction of a Non-native Interdomain Disulfide Bond in Its Receptor
[作者:Gardsvoll, H; Kjaergaard, M; Jacobsen, B; Kriegbaum, MC; Huang, MD; Ploug, M,期刊:Journal of Biological Chemistry, 页码:43515-43526 , 文章类型: Article,,卷期:2011年286-50]
- The high-affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) plays a regulatory role for both extravascular fibrinolysis and uPAR-mediated adhesion and ...
- Structural Basis for the 14-3-3 Protein-dependent Inhibition of the Regulator of G Protein Signaling 3 (RGS3) Function
[作者:Rezabkova, L; Man, P; Novak, P; Herman, P; Vecer, J; Obsilova, V; Obsil, T,期刊:Journal of Biological Chemistry, 页码:43527-43536 , 文章类型: Article,,卷期:2011年286-50]
- Regulator of G protein signaling (RGS) proteins function as GTPase-activating proteins for the alpha-subunit of heterotrimeric G proteins. The function of certain RGS proteins is negatively regulated by 14-3-3 proteins, ...
- Compensatory Regulation of Dopamine after Ablation of the Tyrosine Hydroxylase Gene in the Nigrostriatal Projection
[作者:Tokuoka, H; Muramatsu, S; Sumi-Ichinose, C; Sakane, H; Kojima, M; Aso, Y; Nomura, T; Metzger, D; Ichinose, H,期刊:Journal of Biological Chemistry, 页码:43549-43558 , 文章类型: Article,,卷期:2011年286-50]
- The tyrosine hydroxylase (TH; EC 1.14.16.2) is a rate-limiting enzyme in the dopamine synthesis and important for the central dopaminergic system, which controls voluntary movements and reward-dependent behaviors. Here, ...
- Protein Kinase C alpha Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs Large Homolog 1 (DLG1)
[作者:O'Neill, AK; Gallegos, LL; Justilien, V; Garcia, EL; Leitges, M; Fields, AP; Hall, RA; Newton, AC,期刊:Journal of Biological Chemistry, 页码:43559-43568 , 文章类型: Article,,卷期:2011年286-50]
- Protein scaffolds maintain precision in kinase signaling by coordinating kinases with components of specific signaling pathways. Such spatial segregation is particularly important in allowing specificity of signaling med...
- Fission Yeast Swi5-Sfr1 Protein Complex, an Activator of Rad51 Recombinase, Forms an Extremely Elongated Dogleg-shaped Structure
[作者:Kokabu, Y; Murayama, Y; Kuwabara, N; Oroguchi, T; Hashimoto, H; Tsutsui, Y; Nozaki, N; Akashi, S; Unzai, S; Shimizu, T; Iwasaki, H; Sato, M; Ikeguchi, M,期刊:Journal of Biological Chemistry, 页码:43569-43576 , 文章类型: Article,,卷期:2011年286-50]
- In eukaryotes, DNA strand exchange is the central reaction of homologous recombination, which is promoted by Rad51 recombinases forming a right-handed nucleoprotein filament on single-stranded DNA, also known as a presyn...
- Monosaccharide Absorption Activity of Arabidopsis Roots Depends on Expression Profiles of Transporter Genes under High Salinity Conditions
[作者:Yamada, K; Kanai, M; Osakabe, Y; Ohiraki, H; Shinozaki, K; Yamaguchi-Shinozaki, K,期刊:Journal of Biological Chemistry, 页码:43577-43586 , 文章类型: Article,,卷期:2011年286-50]
- Plant roots are able to absorb sugars from the rhizosphere but also release sugars and other metabolites that are critical for growth and environmental signaling. Reabsorption of released sugar molecules could help reduc...
- Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. (vol 284, pg 21057, 2009)
[作者:Leow, CC; Wang, BE; Ross, J; Chan, SM; Zha, JP; Carano, RAD; Frantz, G; Shen, MM; de Sauvage, FJ; Gao, WQ,期刊:Journal of Biological Chemistry, 页码:43587-43587 , 文章类型: Correction,,卷期:2011年286-50]
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