- Accelerated and Progressive and Lethal Liver Fibrosis in Mice That Lack Interleukin (IL)-10, IL-12p40, and IL-13R alpha 2
[作者:Mentink-Kane, MM; Cheever, AW; Wilson, MS; Madala, SK; Beers, LM; Ramalingam, TR; Wynn, TA,期刊:Gastroenterology, 页码:2200-2209 , 文章类型: Article,,卷期:2011年141-6]
- BACKGROUND & AIMS: Progressive fibrosis contributes to the morbidity of several chronic diseases; it typically develops slowly, so the mechanisms that control its progression and resolution have been difficult to model. ...
- Intra-acinar Trypsinogen Activation Mediates Early Stages of Pancreatic Injury but Not Inflammation in Mice With Acute Pancreatitis
[作者:Dawra, R; Sah, RP; Dudeja, V; Rishi, L; Talukdar, R; Garg, P; Saluja, AK,期刊:Gastroenterology, 页码:2210-U380 , 文章类型: Article,,卷期:2011年141-6]
- BACKGROUND & AIMS: The role of trypsinogen activation in the pathogenesis of acute pancreatitis (AP) has not been clearly established. METHODS: We generated and characterized mice lacking trypsinogen isoform 7 (T7) gene ...
- c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target
[作者:Li, CW; Wu, JJ; Hynes, M; Dosch, J; Sarkar, B; Welling, TH; di Magliano, MP; Simeone, DM,期刊:Gastroenterology, 页码:2218-U395 , 文章类型: Article,,卷期:2011年141-6]
- BACKGROUND & AIMS: Growth of many different tumor types requires a population of self-renewing cancer stem cells (CSCs). c-Met is a marker of normal mouse pancreatic stem and progenitor cells; we investigated whether it ...
- Trypsin Reduces Pancreatic Ductal Bicarbonate Secretion by Inhibiting CFTR Cl(-) Channels and Luminal Anion Exchangers
[作者:Pallagi, P; Venglovecz, V; Rakonczay, Z; Borka, K; Korompay, A; Ozsvari, B; Judak, L; Sahin-Toth, M; Geisz, A; Schnur, A; Maleth, J; Takacs, T; Gray, MA; Argent, BE; Mayerle, J; Lerch, MM; Wittmann, T; Hegyi, P,期刊:Gastroenterology, 页码:2228-U413 , 文章类型: Article,,卷期:2011年141-6]
- BACKGROUND & AIMS: The effects of trypsin on pancreatic ductal epithelial cells (PDECs) vary among species and depend on the localization of proteinase-activated receptor 2 (PAR-2). We compared PAR-2 localization in huma...
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