- Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants
[作者:Park, JH; Gail, MH; Weinberg, CR; Carroll, RJ; Chung, CC; Wang, ZM; Chanock, SJ; Fraumeni, JF; Chatterjee, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18026-18031 , 文章类型: Article,,卷期:2011年108-44]
- Recent discoveries of hundreds of common susceptibility SNPs from genome-wide association studies provide a unique opportunity to examine population genetic models for complex traits. In this report, we investigate distr...
- Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing
[作者:Walsh, T; Casadei, S; Lee, MK; Pennil, CC; Nord, AS; Thornton, AM; Roeb, W; Agnew, KJ; Stray, SM; Wickramanayake, A; Norquist, B; Pennington, KP; Garcia, RL; King, MC; Swisher, EM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18032-18037 , 文章类型: Article,,卷期:2011年108-44]
- Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited mutations is not known. Using targeted capture...
- Sex-linked transcription factor involved in a shift of sex-pheromone preference in the silkmoth Bombyx mori
[作者:Fujii, T; Fujii, T; Namiki, S; Abe, H; Sakurai, T; Ohnuma, A; Kanzaki, R; Katsuma, S; Ishikawa, Y; Shimada, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18038-18043 , 文章类型: Article,,卷期:2011年108-44]
- In the sex-pheromone communication systems of moths, odorant receptor (Or) specificity as well as higher olfactory information processing in males should be finely tuned to the pheromone of conspecific females. According...
- Differential regulation of self-reactivity discriminates between IgG(+) human circulating memory B cells and bone marrow plasma cells
[作者:Scheid, JF; Mouquet, H; Kofer, J; Yurasov, S; Nussenzweig, MC; Wardemann, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18044-18048 , 文章类型: Article,,卷期:2011年108-44]
- Long-term humoral immunity is maintained by the formation of high-affinity class-switched memory B cells and long-lived anti-body-secreting plasma cells. In healthy humans, a substantial fraction of IgG-positive memory B...
- Langerhans cells are precommitted to immune tolerance induction
[作者:Shklovskaya, E; O'Sullivan, BJ; Ng, LG; Roediger, B; Thomas, R; Weninger, W; de St Groth, BF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18049-18054 , 文章类型: Article,,卷期:2011年108-44]
- Antigen-dependent interactions between T lymphocytes and dendritic cells (DCs) can produce two distinct outcomes: tolerance and immunity. It is generally considered that all DC subsets are capable of supporting both tole...
- Inflammasome activation and IL-1 beta target IL-1 alpha for secretion as opposed to surface expression
[作者:Fettelschoss, A; Kistowska, M; LeibundGut-Landmann, S; Beer, HD; Johansen, P; Senti, G; Contassot, E; Bachmann, MF; French, LE; Oxenius, A; Kundig, TM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18055-18060 , 文章类型: Article,,卷期:2011年108-44]
- Interleukin-1 alpha (IL-1 alpha) and -beta both bind to the same IL-1 receptor (IL-1R) and are potent proinflammatory cytokines. Production of proinflammatory (pro)-IL-1 alpha and pro-IL-1 beta is induced by Toll-like re...
- Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression
[作者:Gao, Q; Steine, EJ; Barrasa, MI; Hockemeyer, D; Pawlak, M; Fu, DD; Reddy, S; Bell, GW; Jaenisch, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18061-18066 , 文章类型: Article,,卷期:2011年108-44]
- Alterations in DNA methylation have been associated with genome-wide hypomethylation and regional de novo methylation in numerous cancers. De novo methylation is mediated by the de novo methyltransferases Dnmt3a and 3b, ...
- Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease
[作者:Olsan, EE; Mukherjee, S; Wulkersdorfer, B; Shillingford, JM; Giovannone, AJ; Todorov, G; Song, XW; Pei, Y; Weimbs, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18067-18072 , 文章类型: Article,,卷期:2011年108-44]
- Autosomal-dominant (AD) polycystic kidney disease (PKD) is a leading cause of renal failure in the United States, and currently lacks available treatment options to slow disease progression. Mutations in the gene coding ...
- Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
[作者:Hirota, Y; Cha, JY; Yoshie, M; Daikoku, T; Dey, SK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18073-18078 , 文章类型: Article,,卷期:2011年108-44]
- Although preterm delivery is a major global health issue, its causes and underlying mechanism remain elusive. Using mutant mice, mimicking aspects of human preterm birth, we show here that uterine decidual senescence ear...
- Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions
[作者:Liljeroos, L; Huiskonen, JT; Ora, A; Susi, P; Butcher, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18085-18090 , 文章类型: Article,,卷期:2011年108-44]
- Measles virus is a highly infectious, enveloped, pleomorphic virus. We combined electron cryotomography with subvolume averaging and immunosorbent electron microscopy to characterize the 3D ultrastructure of the virion. ...
- Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus
[作者:DeLeo, FR; Kennedy, AD; Chen, L; Wardenburg, JB; Kobayashi, SD; Mathema, B; Braughton, KR; Whitney, AR; Villaruz, AE; Martens, CA; Porcella, SF; McGavin, MJ; Otto, M; Musser, JM; Kreiswirth, BN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18091-18096 , 文章类型: Article,,卷期:2011年108-44]
- Staphylococcus aureus is a bacterial pathogen known to cause infections in epidemic waves. One such epidemic was caused by a clone known as phage-type 80/81, a penicillin-resistant strain that rose to world prominence in...
- Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death
[作者:Vosler, PS; Gao, YQ; Brennan, CS; Yanagiya, A; Gan, Y; Cao, GD; Zhang, F; Morley, SJ; Sonenberg, N; Bennett, MVL; Chen, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18102-18107 , 文章类型: Article,,卷期:2011年108-44]
- Persistent protein synthesis inhibition (PSI) is a robust predictor of eventual neuronal death following cerebral ischemia. We thus tested the hypothesis that persistent PSI inhibition and neuronal death are causally lin...
- Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse
[作者:Lindfors, C; Nilsson, IAK; Garcia-Roves, PM; Zuberi, AR; Karimi, M; Donahue, LR; Roopenian, DC; Mulder, J; Uhlen, M; Ekstrom, TJ; Davisson, MT; Hokfelt, TGM; Schalling, M; Johansen, JE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18108-18113 , 文章类型: Article,,卷期:2011年108-44]
- The anorectic anx/anx mouse exhibits disturbed feeding behavior and aberrances, including neurodegeneration, in peptidergic neurons in the appetite regulating hypothalamic arcuate nucleus. Poor feeding in infants, as wel...
- Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system
[作者:Zimmermann, K; Lennerz, JK; Hein, A; Link, AS; Kaczmarek, JS; Delling, M; Uysal, S; Pfeifer, JD; Riccio, A; Clapham, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18114-18119 , 文章类型: Article,,卷期:2011年108-44]
- Detection and adaptation to cold temperature is crucial to survival. Cold sensing in the innocuous range of cold (> 10-15 degrees C) in the mammalian peripheral nervous system is thought to rely primarily on transient re...
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