- Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly
[作者:Sitar, T; Gallinger, J; Ducka, AM; Ikonen, TP; Wohlhoefler, M; Schmoller, KM; Bausch, AR; Joel, P; Trybus, KM; Noegel, AA; Schleicher, M; Huber, R; Holak, TA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19575-19580 , 文章类型: Article,,卷期:2011年108-49]
- The Spire protein is a multifunctional regulator of actin assembly. We studied the structures and properties of Spire-actin complexes by X-ray scattering, X-ray crystallography, total internal reflection fluorescence mic...
- Mathematical modeling of prostate cancer progression in response to androgen ablation therapy
[作者:Jain, HV; Clinton, SK; Bhinder, A; Friedman, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19701-19706 , 文章类型: Article,,卷期:2011年108-49]
- Prostate cancer progression depends in part on the complex interactions between testosterone, its active metabolite DHT, and androgen receptors. In a metastatic setting, the first line of treatment is the elimination of ...
- Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk
[作者:Yasuno, K; Bakircioglu, M; Low, SK; Bilguvar, K; Gaal, E; Ruigrok, YM; Niemela, M; Hata, A; Bijlenga, P; Kasuya, H; Jaaskelainen, JE; Krex, D; Auburger, G; Simon, M; Krischek, B; Ozturk, AK; Mane, S; Rinkel, GJE; Steinmetz, H; Hernesniemi, J; Schaller, K; Zembutsu, H; Inoue, I; Palotie, A; Cambien, F; Nakamura, Y; Lifton, RP; Gunel, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19707-19712 , 文章类型: Article,,卷期:2011年108-49]
- The pathogenesis of intracranial aneurysm (IA) formation and rupture is complex, with significant contribution from genetic factors. We previously reported genome-wide association studies based on European discovery and ...
- beta(2)-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids
[作者:Holden, NS; Bell, MJ; Rider, CF; King, EM; Gaunt, DD; Leigh, R; Johnson, M; Siderovski, DP; Heximer, SP; Giembycz, MA; Newton, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19713-19718 , 文章类型: Article,,卷期:2011年108-49]
- In asthma and chronic obstructive pulmonary disease, activation of G(q)-protein-coupled receptors causes bronchoconstriction. In each case, the management of moderate-to-severe disease uses inhaled corticosteroid (glucoc...
- The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
[作者:Mezzaroma, E; Toldo, S; Farkas, D; Seropian, IM; Van Tassell, BW; Salloum, FN; Kannan, HR; Menna, AC; Voelkel, NF; Abbate, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19725-19730 , 文章类型: Article,,卷期:2011年108-49]
- Acute myocardial infarction (AMI) initiates an intense inflammatory response that promotes cardiac dysfunction, cell death, and ventricular remodeling. The molecular events underlying this inflammatory response, however,...
- Mutually facilitated dispersal between the nonmotile fungus Aspergillus fumigatus and the swarming bacterium Paenibacillus vortex
[作者:Ingham, CJ; Kalisman, O; Finkelshtein, A; Ben-Jacob, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19731-19736 , 文章类型: Article,,卷期:2011年108-49]
- In the heterogeneous environment surrounding plant roots (the rhizosphere), microorganisms both compete and cooperate. Here, we show that two very different inhabitants of the rhizosphere, the nonmotile fungus Aspergillu...
- High-resolution human cytomegalovirus transcriptome
[作者:Gatherer, D; Seirafian, S; Cunningham, C; Holton, M; Dargan, DJ; Baluchova, K; Hector, RD; Galbraith, J; Herzyk, P; Wilkinson, GWG; Davison, AJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19755-19760 , 文章类型: Article,,卷期:2011年108-49]
- Deep sequencing was used to bring high resolution to the human cytomegalovirus (HCMV) transcriptome at the stage when infectious virion production is under way, and major findings were confirmed by extensive experimentat...
- Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis
[作者:Konopacki, FA; Jaafari, N; Rocca, DL; Wilkinson, KA; Chamberlain, S; Rubin, P; Kantamneni, S; Mellor, JR; Henley, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19772-19777 , 文章类型: Article,,卷期:2011年108-49]
- The surface expression and regulated endocytosis of kainate (KA) receptors (KARs) plays a critical role in neuronal function. PKC can modulate KAR trafficking, but the sites of action and molecular consequences have not ...
- Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
[作者:Majumdar, S; Grinnell, S; Le Rouzic, V; Burgman, M; Polikar, L; Ansonoff, M; Pintar, J; Pan, YX; Pasternak, GW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19778-19783 , 文章类型: Article,,卷期:2011年108-49]
- Pain remains a pervasive problem throughout medicine, transcending all specialty boundaries. Despite the extraordinary insights into pain and its mechanisms over the past few decades, few advances have been made with ana...
- Measuring time with different neural chronometers during a synchronization-continuation task
[作者:Merchant, H; Zarco, W; Perez, O; Prado, L; Bartolo, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19784-19789 , 文章类型: Article,,卷期:2011年108-49]
- Temporal information processing is critical for many complex behaviors including speech and music cognition, yet its neural substrate remains elusive. We examined the neurophysiological properties of medial premotor cort...
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