- Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human
[作者:Takahashi, Y; Westfield, GH; Oleskie, AN; Trievel, RC; Shilatifard, A; Skiniotis, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20526-20531 , 文章类型: Article,,卷期:2011年108-51]
- Histone H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively. Here we have reconsti...
- Vertebrate-specific glutaredoxin is essential for brain development
[作者:Brautigam, L; Schutte, LD; Godoy, JR; Prozorovski, T; Gellert, M; Hauptmann, G; Holmgren, A; Lillig, CH; Berndt, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20532-20537 , 文章类型: Article,,卷期:2011年108-51]
- Cellular functions and survival are dependent on a tightly controlled redox potential. Currently, an increasing amount of data supports the concept of local changes in the redox environment and specific redox signaling e...
- Structural insights into protein arginine symmetric dimethylation by PRMT5
[作者:Sun, LT; Wang, MZ; Lv, ZY; Yang, N; Liu, YF; Bao, SL; Gong, WM; Xu, RM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20538-20543 , 文章类型: Article,,卷期:2011年108-51]
- Symmetric and asymmetric dimethylation of arginine are isomeric protein posttranslational modifications with distinct biological effects, evidenced by the methylation of arginine 3 of histone H4 (H4R3): symmetric dimethy...
- 3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity
[作者:Landsberg, MJ; Jones, SA; Rothnagel, R; Busby, JN; Marshall, SDG; Simpson, RM; Lott, JS; Hankamer, B; Hurst, MRH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20544-20549 , 文章类型: Article,,卷期:2011年108-51]
- Toxin complex (Tc) proteins are a class of bacterial protein toxins that form large, multisubunit complexes. Comprising TcA, B, and C components, they are of great interest because many exhibit potent insecticidal activi...
- IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis
[作者:Kelley, JM; Monach, PA; Ji, CY; Zhou, YB; Wu, JM; Tanaka, S; Mahr, AD; Johnson, S; McAlear, C; Cuthbertson, D; Carette, S; Davis, JC; Dellaripa, PF; Hoffman, GS; Khalidi, N; Langford, CA; Seo, P; St Clair, EW; Specks, U; Stone, JH; Spiera, RF; Ytterberg, SR; Merkel, PA; Edberg, JC; Kimberly, RP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20736-20741 , 文章类型: Article,,卷期:2011年108-51]
- Granulomatosis with polyangiitis (Wegener's) is a rare autoimmune neutrophil-mediated vasculitis that can cause renal disease and mucosal manifestations. Antineutrophil cytoplasmic antibodies (ANCA) are present in many p...
- Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses
[作者:Sandbulte, MR; Westgeest, KB; Gao, J; Xu, XY; Klimov, AI; Russell, CA; Burke, DF; Smith, DJ; Fouchier, RAM; Eichelberger, MC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20748-20753 , 文章类型: Article,,卷期:2011年108-51]
- Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemag...
- Evidence for a hierarchy of predictions and prediction errors in human cortex
[作者:Wacongne, C; Labyt, E; van Wassenhove, V; Bekinschtein, T; Naccache, L; Dehaene, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20754-20759 , 文章类型: Article,,卷期:2011年108-51]
- According to hierarchical predictive coding models, the cortex constantly generates predictions of incoming stimuli at multiple levels of processing. Responses to auditory mismatches and omissions are interpreted as refl...
- Brain network local interconnectivity loss in aging APOE-4 allele carriers
[作者:Brown, JA; Terashima, KH; Burggren, AC; Ercoli, LM; Miller, KJ; Small, GW; Bookheimer, SY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20760-20765 , 文章类型: Article,,卷期:2011年108-51]
- Old age and possession of the APOE-4 allele are the two main risk factors for developing later onset Alzheimer's Disease (AD). Carriers of the APOE-4 allele have known differences in intrinsic functional brain network ac...
- Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
[作者:Rappold, PM; Cui, M; Chesser, AS; Tibbett, J; Grima, JC; Duan, LH; Sen, N; Javitch, JA; Tieu, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20766-20771 , 文章类型: Article,,卷期:2011年108-51]
- The herbicide paraquat (PQ) has increasingly been reported in epidemiological studies to enhance the risk of developing Parkinson's disease (PD). Furthermore, case-control studies report that individuals with genetic var...
- Pannexins in ischemia-induced neurodegeneration
[作者:Bargiotas, P; Krenz, A; Hormuzdi, SG; Ridder, DA; Herb, A; Barakat, W; Penuela, S; von Engelhardt, J; Monyer, H; Schwaninger, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20772-20777 , 文章类型: Article,,卷期:2011年108-51]
- Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia. To directly test a ...
- Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells
[作者:Cho, S; Lu, ML; He, XL; Ee, PLR; Bhat, U; Schneider, E; Miele, L; Beck, WT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20778-20783 , 文章类型: Article,,卷期:2011年108-51]
- Multidrug resistance (MDR) is a barrier to successful cancer chemotherapy. Although MDR is associated with overexpression of ATP-binding cassette (ABC) membrane transporters, mechanisms behind their up-regulation are not...
- Alternatively spliced domains interact to regulate BK potassium channel gating
[作者:Johnson, BE; Glauser, DA; Dan-Glauser, ES; Halling, DB; Aldrich, RW; Goodman, MB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20784-20789 , 文章类型: Article,,卷期:2011年108-51]
- Most human genes contain multiple alternative splice sites believed to extend the complexity and diversity of the proteome. However, little is known about how interactions among alternative exons regulate protein functio...
- Energy landscape of the reactions governing the Na(+) deeply occluded state of the Na(+)/K(+)-ATPase in the giant axon of the Humboldt squid
[作者:Castillo, JP; De Giorgis, D; Basilio, D; Gadsby, DC; Rosenthal, JJC; Latorre, R; Holmgren, M; Bezanilla, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20556-20561 , 文章类型: Article,,卷期:2011年108-51]
- The Na(+)/K(+) pump is a nearly ubiquitous membrane protein in animal cells that uses the free energy of ATP hydrolysis to alternatively export 3Na(+) from the cell and import 2K(+) per cycle. This exchange of ions produ...
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