- Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5
[作者:Kim, YH; Donald, JE; Grigoryan, G; Leser, GP; Fadeev, AY; Lamb, RA; DeGrado, WF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20992-20997 , 文章类型: Article,,卷期:2011年108-52]
- During cell entry, enveloped viruses fuse their viral membrane with a cellular membrane in a process driven by energetically favorable, large-scale conformational rearrangements of their fusion proteins. Structures of th...
- Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region
[作者:Yu, JW; Jeffrey, PD; Ha, JY; Yang, XL; Shi, YG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21004-21009 , 文章类型: Article,,卷期:2011年108-52]
- The mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase, a key component of the Carma1/Bcl10/MALT1 signalosome, is critical for NF-kappa B signaling in multiple contexts. MALT1 is thought to fu...
- Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
[作者:Peisley, A; Lin, C; Wu, B; Orme-Johnson, M; Liu, MY; Walz, T; Hur, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21010-21015 , 文章类型: Article,,卷期:2011年108-52]
- MDA5, an RIG-I-like helicase, is a conserved cytoplasmic viral RNA sensor, which recognizes dsRNA from a wide-range of viruses in a length-dependent manner. It has been proposed that MDA5 forms higher-order structures up...
- Perforin activity at membranes leads to invaginations and vesicle formation
[作者:Praper, T; Sonnen, AFP; Kladnik, A; Andrighetti, AO; Viero, G; Morris, KJ; Volpi, E; Lunelli, L; Serra, MD; Froelich, CJ; Gilbert, RJC; Anderluh, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21016-21021 , 文章类型: Article,,卷期:2011年108-52]
- The cytotoxic cell granule secretory pathway is essential for immune defence. How the pore-forming protein perforin (PFN) facilitates the cytosolic delivery of granule-associated proteases (granzymes) remains enigmatic. ...
- Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis
[作者:Chaikuad, A; Froese, DS; Berridge, G; von Delft, F; Oppermann, U; Yue, WW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21028-21033 , 文章类型: Article,,卷期:2011年108-52]
- Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of huma...
- An inhibitory C-terminal region dictates the specificity of A-adding enzymes
[作者:Tretbar, S; Neuenfeldt, A; Betat, H; Morl, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21040-21045 , 文章类型: Article,,卷期:2011年108-52]
- For efficient aminoacylation, tRNAs carry the conserved 3'-terminal sequence C-C-A, which is synthesized by highly specific tRNA nucleotidyltransferases (CCA-adding enzymes). In several prokaryotes, this function is acco...
- Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase
[作者:Ando, N; Brignole, EJ; Zimanyi, CM; Funk, MA; Yokoyama, K; Asturias, FJ; Stubbe, J; Drennan, CL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21046-21051 , 文章类型: Article,,卷期:2011年108-52]
- Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that allosteric regulation of RNR activity is v...
- A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target
[作者:Schiering, N; D'Arcy, A; Villard, F; Simic, O; Kamke, M; Monnet, G; Hassiepen, U; Svergun, DI; Pulfer, R; Eder, J; Raman, P; Bodendorf, U,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21052-21056 , 文章类型: Article,,卷期:2011年108-52]
- Hepatitis C virus (HCV) infection is a global health burden with over 170 million people infected worldwide. In a significant portion of patients chronic hepatitis C infection leads to serious liver diseases, including f...
- Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility
[作者:De Simone, A; Dhulesia, A; Soldi, G; Vendruscolo, M; Hsu, STD; Chiti, F; Dobson, CM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21057-21062 , 文章类型: Article,,卷期:2011年108-52]
- The identification of the factors that enable normally folded proteins to remain in their soluble and functional states is crucial for a comprehensive understanding of any biological system. We have determined a series o...
- Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)
[作者:Li, DL; Chen, SW; Bellomo, EA; Tarasov, AI; Kaut, C; Rutter, GA; Li, WH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21063-21068 , 文章类型: Article,,卷期:2011年108-52]
- Current methods of monitoring insulin secretion lack the required spatial and temporal resolution to adequately map the dynamics of exocytosis of native insulin granules in intact cell populations in three dimensions. Ex...
- Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells
[作者:Colombo, SL; Palacios-Callender, M; Frakich, N; Carcamo, S; Kovacs, I; Tudzarova, S; Moncada, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21069-21074 , 文章类型: Article,,卷期:2011年108-52]
- During cell division, the activation of glycolysis is tightly regulated by the action of two ubiquitin ligases, anaphase-promoting complex/cyclosome-Cdh1 (APC/C-Cdh1) and SKP1/CUL-1/F-box protein-beta-transducin repeat-c...
- Bleaching/blinking assisted localization microscopy for superresolution imaging using standard fluorescent molecules
[作者:Burnette, DT; Sengupta, P; Dai, YH; Lippincott-Schwartz, J; Kachar, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21081-21086 , 文章类型: Article,,卷期:2011年108-52]
- Superresolution imaging techniques based on the precise localization of single molecules, such as photoactivated localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM), achieve high resol...
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