- Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8
[作者:Takeda, K; Tonthat, NK; Glover, T; Xu, WJ; Koonin, EV; Yanagida, M; Schumacher, MA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16950-16955 , 文章类型: Article,,卷期:2011年108-41]
- Degradation of nuclear proteins by the 26S proteasome is essential for cell viability. In yeast, the nuclear envelope protein Cut8 mediates nuclear proteasomal sequestration by an uncharacterized mechanism. Here we descr...
- Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis
[作者:Abu Tarboush, N; Jensen, LMR; Yukl, ET; Geng, JF; Liu, AM; Wilmot, CM; Davidson, VL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16956-16961 , 文章类型: Article,,卷期:2011年108-41]
- The diheme enzyme MauG catalyzes the posttranslational modification of the precursor protein of methylamine dehydrogenase (preMADH) to complete biosynthesis of its protein-derived tryptophan tryptophylquinone (TTQ) cofac...
- Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions
[作者:Mishra, A; Lai, GH; Schmidt, NW; Sun, VZ; Rodriguez, AR; Tong, R; Tang, L; Cheng, JJ; Deming, TJ; Kamei, DT; Wong, GCL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16883-16888 , 文章类型: Article,,卷期:2011年108-41]
- Cell-penetrating peptides (CPPs), such as the HIV TAT peptide, are able to translocate across cellular membranes efficiently. A number of mechanisms, from direct entry to various endocytotic mechanisms (both receptor ind...
- Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution
[作者:Jiang, Y; Douglas, NR; Conley, NR; Miller, EJ; Frydman, J; Moerner, WE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16962-16967 , 文章类型: Article,,卷期:2011年108-41]
- In order to operate in a coordinated fashion, multisubunit enzymes use cooperative interactions intrinsic to their enzymatic cycle, but this process remains poorly understood. Accordingly, ATP number distributions in var...
- Binding of blood proteins to carbon nanotubes reduces cytotoxicity
[作者:Ge, CC; Du, JF; Zhao, LN; Wang, LM; Liu, Y; Li, DH; Yang, YL; Zhou, RH; Zhao, YL; Chai, ZF; Chen, CY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16968-16973 , 文章类型: Article,,卷期:2011年108-41]
- With the potential wide uses of nanoparticles such as carbon nanotubes in biomedical applications, and the growing concerns of nanotoxicity of these engineered nanoparticles, the importance of nanoparticle-protein intera...
- Ultrahigh resolution protein structures using NMR chemical shift tensors
[作者:Wylie, BJ; Sperling, LJ; Nieuwkoop, AJ; Franks, WT; Oldfield, E; Rienstra, CM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16974-16979 , 文章类型: Article,,卷期:2011年108-41]
- NMR chemical shift tensors (CSTs) in proteins, as well as their orientations, represent an important new restraint class for protein structure refinement and determination. Here, we present the first determination of bot...
- Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis
[作者:Chen, CL; Stevens, B; Kaur, J; Smilansky, Z; Cooperman, BS; Goldman, YE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16980-16985 , 文章类型: Article,,卷期:2011年108-41]
- During protein synthesis, deacylated transfer RNAs leave the ribosome via an exit (E) site after mRNA translocation. How the ribosome regulates tRNA dissociation and whether functional linkages between the aminoacyl (A) ...
- The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM)
[作者:Zheng, GA; Lee, SA; Antebi, Y; Elowitz, MB; Yang, CH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16889-16894 , 文章类型: Article,,卷期:2011年108-41]
- We report a chip-scale lensless wide-field-of-view microscopy imaging technique, subpixel perspective sweeping microscopy, which can render microscopy images of growing or confluent cell cultures autonomously. We demonst...
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